Anti-inflammatory and wound healing effects of an essential oils-based bioadhesive gel after oral mucosa biopsies: preliminary results

Scotti, Federico; Decani, Sem; Sardella, Andrea; Varoni, Elena Maria; Lodi, Giovanni

doi:10.14715/cmb/2018.64.8.12

Cited by 7 publications

(4 citation statements)

References 33 publications

(43 reference statements)

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“…EOs are isolated by steam/hydro-distillation or by cold expression [ 15 ]. They are known to have multiple biological activities, such as antibacterial, antiviral, antifungal, antioxidant, wound healing, anti-inflammatory or immunomodulatory properties [ 16 , 17 , 18 , 19 ]. Given the wide spread of bacterial resistance, disrupting the QS mechanism seems to be an interesting alternative.…”

Section: Introductionmentioning

confidence: 99%

Anti-Quorum Sensing Activity of 12 Essential Oils on chromobacterium violaceum and Specific Action of cis-cis-p-Menthenolide from Corsican Mentha suaveolens ssp. Insularis

et al. 2018

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Quorum sensing (QS) is a bacterial communication mechanism used to express various survival or virulence traits leading to enhanced resistance. Chromobacterium violaceum is a commonly used strain that highlights anti-QS action of bioactive substances. Here, we wanted to see if 12 selected essential oils (EO) could exert anti-QS activity. We measured the sublethal minimal QS inhibitory concentration (MQSIC) by assessing violacein production of C. violaceum along with bacterial growth. To confirm the QS disruption, we also proceed to surface bacterial observations using scanning electron microscopy (SEM). We showed that cis-cis-p-menthenolide extracted and isolated from a plant endemic to occidental Mediterranean Sea islands, Mentha suaveolens ssp. insularis, acts as an inhibitor of violacein production and biofilm formation. Measured MQSIC was much lower than the minimal inhibitory concentration (MIC): 0.10 mg·mL−1 vs. 3.00 mg·mL−1. Moreover, disturbance of QS-related traits was confirmed by the degradation of C. violaceum biofilm matrix. There is a clear structure–activity relationship between cis-cis-p-menthenolide and anti-QS activity. Indeed, its isomer molecule (mintlactone) exerts a poor anti-QS action. These results indicate that inhibition of violacein production and biofilm formation by cis-cis-p-menthenolide might be related to a disruption in the QS mechanism.

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Section: Introductionmentioning

confidence: 99%

Anti-Quorum Sensing Activity of 12 Essential Oils on chromobacterium violaceum and Specific Action of cis-cis-p-Menthenolide from Corsican Mentha suaveolens ssp. Insularis

et al. 2018

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“…An EO preparation administered for the treatment of vulvovaginitis, such as tea tree and geranium oil reaches the target site in a direct way and can reduce and eliminate infectious causes and inflammation ( Blackwell, 1991 ; Maruyama et al, 2008 ). Oral infections, postoperative wounds or bad breath caused by bacteria, as well as xerostomia can be treated with appropriate EOs in e.g., mouthwashes ( Fischman et al, 2004 ; Alshehri, 2018 ; Scotti et al, 2018 ; Filipović et al, 2020 ). Syzygium aromaticum (L.) Merr.…”

Section: Therapeutic Uses Of Eosmentioning

confidence: 99%

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

et al. 2022

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Essential oils (EOs) and their individual volatile organic constituents have been an inherent part of our civilization for thousands of years. They are widely used as fragrances in perfumes and cosmetics and contribute to a healthy diet, but also act as active ingredients of pharmaceutical products. Their antibacterial, antiviral, and anti-inflammatory properties have qualified EOs early on for both, the causal and symptomatic therapy of a number of diseases, but also for prevention. Obtained from natural, mostly plant materials, EOs constitute a typical example of a multicomponent mixture (more than one constituent substances, MOCS) with up to several hundreds of individual compounds, which in a sophisticated composition make up the property of a particular complete EO. The integrative use of EOs as MOCS will play a major role in human and veterinary medicine now and in the future and is already widely used in some cases, e.g., in aromatherapy for the treatment of psychosomatic complaints, for inhalation in the treatment of respiratory diseases, or topically administered to manage adverse skin diseases. The diversity of molecules with different functionalities exhibits a broad range of multiple physical and chemical properties, which are the base of their multi-target activity as opposed to single isolated compounds. Whether and how such a broad-spectrum effect is reflected in natural mixtures and which kind of pharmacological potential they provide will be considered in the context of ONE Health in more detail in this review.

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“…In recent years, numerous studies had been conducted to identify compounds that can be used as an adjunct to the current approach to managing oral biofilm, especially for patients sensitive to CHX. One of the compounds is essential oil due to its effective therapeutic activity against pathogenic biofilms (Wang et al, 2016;Scotti et al, 2018). The sweet basil leaves essential oil (SBEO) used in this study has shown antimicrobial, antifungal, anti-inflammatory, anticancer, and analgesic properties (Beier et al, 2014;Jin et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

THE ANTIMICROBIAL AND ANTIBIOFILM POTENTIAL OF SWEET BASIL ESSENTIAL OIL ON Streptococcus mutans AND Staphylococcus aureus

Zain

AMIN

NORDIN

et al. 2022

MAB

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The antimicrobial and antibiofilm activities of sweet basil essential oil (SBEO) against oral microorganisms, Streptococcusmutans (S. mutans) and Staphylococcus aureus (S. aureus) were determined in this study. The antimicrobial activities wereevaluated using the disk diffusion method (DDM), where Minimum Inhibitory Concentration (MIC) and Minimum BactericidalConcentration (MBC) were tested against both bacteria. Different formulations of SBEO (microemulsion, emulsion, water)were tested for biofilm dispersion assay on 24 h of preformed biofilm. Commercial chlorhexidine (CHX) 0.12% w/v wasused as a positive control. The scanning electron microscope (SEM) was used to observe the changes on the treated surface.The data were analyzed using SPSS Version 27.0. A Kruskal-Wallis test followed by a Post-hoc Mann-Whitney U test wasapplied, and the level of significance was set at p<0.05. All formulations of SBEO showed antimicrobial activities against thetested microorganisms. Exposure to 2.5% (v/v) microemulsion for two min exhibited 42.56% and 32.10% (p<0.001) of biofilmdispersion for S. mutans and S. aureus, respectively. The SEM micrographs revealed the number of microorganisms on thetreated group surface reduced compared to the negative controls. SBEO exerts an antimicrobial and antibiofilm effect on S.mutans and S. aureus. This finding suggests that the SBEO microemulsion has the potential to control planktonic S. mutans andS. aureus and their biofilm formation in the oral environment

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Anti-inflammatory and wound healing effects of an essential oils-based bioadhesive gel after oral mucosa biopsies: preliminary results

Cited by 7 publications

References 33 publications

Anti-Quorum Sensing Activity of 12 Essential Oils on chromobacterium violaceum and Specific Action of cis-cis-p-Menthenolide from Corsican Mentha suaveolens ssp. Insularis

Anti-Quorum Sensing Activity of 12 Essential Oils on chromobacterium violaceum and Specific Action of cis-cis-p-Menthenolide from Corsican Mentha suaveolens ssp. Insularis

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

THE ANTIMICROBIAL AND ANTIBIOFILM POTENTIAL OF SWEET BASIL ESSENTIAL OIL ON Streptococcus mutans AND Staphylococcus aureus

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