RESUMO: "Efeitos farmacológicos do monoterpeno α,β-epoxi-carvona em camundongos". O monoterpeno α,β-epóxi-carvona (EC) nas doses de 200, 300 e 400 mg/kg administrado por via i.p. em camundongos diminuiu signifi cativamente a atividade motora dos animais, quando comparado aos controles, até 120 minutos após a administração. As doses de 300 e 400 mg/kg induziram um aumento signifi cativo do tempo de sono dos animais não alterando, no entanto, a sua latência. O EC na dose de 400 mg/kg induziu uma redução no tempo de permanência dos animais na barra giratória (teste do rotarod). Os resultados sugerem um possível efeito central.Unitermos: Efeito farmacológico, óleo essencial, monoterpeno, α,β-epóxi-carvona, camundongos. ABSTRACT:The monoterpene α,β-epoxy-carvone (EC) in doses of 200, 300 or 400 mg/kg injected by i.p. route in mice caused a signifi cant decrease in the motor activity of animals when compared with the control group, up to 120 minutes after the administration. The doses of 300 or 400 mg/kg had induced a signifi cant increase of in the sleeping time of animals not having modifi ed, however, the latency. The EC in the dose of 400 mg/kg reduced the remaining time of the animals on the rotating rod (Rotarod test). These results suggest a possible central effect.
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