Biological activity of the aqueous extract of Lychnophora pinaster Mart.

Silveira, Dâmaris; Wagner, Hildebert; Chiari, Égler; Lombardi, Júlio Antônio; Assunção, A.C.; Oliveira, Alaı́de Braga de; Raslan, D. S.

doi:10.1590/s0102-695x2005000400006

Cited by 13 publications

(10 citation statements)

References 21 publications

(21 reference statements)

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“…Quercetin (1), for example, presented antiprotozoal effect against Plasmodium falciparum (IC 50 = 14 µM), Trypanosoma brucei brucei (IC 50 = 13.2 µM), Leishmania donovani (IC 50 = 63.8 µM) (Camacho et al, 2002), T. brucei and T. rhodesiense (Williamson & Finnigan, 1978). In addition, this compound was described as a constituent of an aqueous extract from Lychnophora pinaster, Asteraceae which showed trypanocidal activity (Silveira et al, 2005). Recently, high leishmanicidal activity was described for such compound (Tasdemir et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Trypanocidal activity of flavonoids and limonoids isolated from Myrsinaceae and Meliaceae active plant extracts

Leite¹,

Neto²,

Ambrozin³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Atividade tripanocida de flavonoides e limonoides isolados de extratos ativos de plantas de Myrsinaceae e Meliaceae". A atividade de extratos brutos de três espécies de Rapanea (Myrsinaceae) e de Cipadessa fruticosa (Meliaceae) foi avaliada in vitro contra formas tripomastigotas de Trypanosoma cruzi. Foram obtidos 33 extratos de diferentes órgãos das espécies estudadas, sendo que onze deles apresentaram atividades significantes (% de lise > 50) nos ensaios realizados. O fracionamento de um extrato ativo dos galhos de R. lancifolia (99,5%) resultou no isolamento de dois flavonoides (quercetina e taxifolina), que apresentaram baixa atividade tripanocida. De um extrato ativo dos frutos de C. fruticosa (97,7%) foram isolados os limonoides mexicanolídeos cipadesina, mexicanolídeo, febrifugina e cipadesina A, que foram moderadamente ativos sobre T. cruzi. Além disso, outros dois flavonoides (flavona e 7-metoxiflavona), previamente ensaiados contra T. cruzi, foram isolados do extrato hexânico dos galhos de C. fruticosa (100%). Os resultados obtidos aqui sugerem que as plantas avaliadas podem constituir fontes de novas substâncias ativas sobre o T. cruzi.Unitermos: Myrsinaceae, Meliaceae, atividade tripanocida, flavonoides, limonoides. ABSTRACT:The activity of crude extracts of three Rapanea species (Myrsinaceae) and Cipadessa fruticosa (Meliaceae) was evaluated in vitro against the trypomastigote forms of Trypanosoma cruzi. Thirty-three extracts from different organs of these species were assayed and eleven of them showed significant activity (lysis % >50). The fractionation of an active extract from branches of R. lancifolia (99.5%) led to the isolation of two flavonoids: quercetin and taxifolin, which have weak trypanocidal activity. Additionally, one active extract from fruits of C. fruticosa (97.7%) afforded mexicanolide limonoids: cipadesin, mexicanolide, febrifugin and cipadesin A, that were slightly active on T. cruzi. Moreover, other two flavonoids (flavone and 7-methoxyflavone), previously assayed against T. cruzi, were isolated from the hexane extract from branches of C. fruticosa (100%). The results presented here suggest that the plants evaluated could be a source of new active compounds against T. cruzi.

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Section: Resultsmentioning

confidence: 99%

Trypanocidal activity of flavonoids and limonoids isolated from Myrsinaceae and Meliaceae active plant extracts

Leite¹,

Neto²,

Ambrozin³

et al. 2010

Rev. bras. farmacogn.

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“…The fl avonoids 10-12 and the α-spinasterol 9 herein described are the fi rst report of these compounds for P. sabulosa. The trypanocidal activity of compound 10 was not determined because only a little amount was isolated and compound 11 is an already known substance and its activity has already been determined (Tasdemir et al, 2006;Silveira et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Trypanocidal activity of coumarins and styryl-2-pyrones from Polygala sabulosa A.W. Bennett (Polygalaceae)

Pizzolatti¹,

Mendes²,

Cunha³

et al. 2008

Rev. bras. farmacogn.

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“…Diversos fl avonóides e ácidos orgânicos também já foram identifi cados em espécies de Lychnophora, entre eles ácido cafeico, ácido isoclorogênico, vitexina, isovitexina e quercetina (Silveira et al, 2005). Na análise em CCD no tempo zero, todas as tinturas apresentaram manchas características para fl avonóides nos Rfs 0,50, e 0,30, além de duas manchas azuis nos Rfs 0,85 e 0,75, atribuídas aos ácidos caféico e isoclorogênico, respectivamente Bladt, 1996).…”

Section: Resultsunclassified

Características físico-químicas e químicas e estudo preliminar de estabilidade de tinturas preparadas com espécies de arnica Lychnophora em comparação com Arnica montana

Maciel¹,

Moreira-Campos²,

Silva³

et al. 2006

Rev. bras. farmacogn.

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Biological activity of the aqueous extract of Lychnophora pinaster Mart.

Cited by 13 publications

References 21 publications

Trypanocidal activity of flavonoids and limonoids isolated from Myrsinaceae and Meliaceae active plant extracts

Trypanocidal activity of flavonoids and limonoids isolated from Myrsinaceae and Meliaceae active plant extracts

Trypanocidal activity of coumarins and styryl-2-pyrones from Polygala sabulosa A.W. Bennett (Polygalaceae)

Características físico-químicas e químicas e estudo preliminar de estabilidade de tinturas preparadas com espécies de arnica Lychnophora em comparação com Arnica montana

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