Confrei: virtudes e problemas

Saito, Maria Lucia; Oliveira, Fernando de

doi:10.1590/s0102-695x1986000100009

Cited by 7 publications

(5 citation statements)

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“…The results showed that allantoin at 5% in soft lotion O/W emulsion has a wound healing effect when compared with the controls groups, however it is not as intense as described in literature. It must be remembered that, despite of extensive use in pharmaceutical and cosmetic preparations and the multiple bibliographic citations that refer to allantoin wound healing properties 6,7 , none of these studies showed, so far, the allantoin histological profile of the wound healing or its action mechanism. This work innovates by demonstrating, qualitatively and quantitatively (by morphometric analysis), the histological profile of wound healing process induced by allantoin.…”

Section: Histological Analysismentioning

confidence: 99%

“…The allantoin (Figure 1), 5-ureide-hydantoin, has been widely cited in literature as holder of numerous pharmacological activities, among them: wound healing 6,7 , anti-irritating, hydrating and remover of necrotic tissue 6 , stimulating the cell mitosis 8 ; as well as promoter of epithelial stimulation, analgesic action 9 and keratolytic activity 10 . For all these reports, the allantoin has been used in cosmetic and pharmaceutical preparations for over 70 years with different therapeutic purposes and especially as a wound healing booster.…”

Section: Introductionmentioning

confidence: 99%

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Profile of wound healing process induced by allantoin

et al. 2010

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Purpose:To evaluate and characterize the wound healing process profile induced by allantoin incorporated in soft lotion oil/water emulsion using the planimetric and histological methods. Methods: Female Wistar rats (n=60) were randomly assigned to 3 experimental groups: (C) control group-without treatment; (E) group treated with soft lotion O/W emulsion excipients; (EA) group treated with soft lotion O/W emulsion containing allantoin 5%. The emulsions either containing or not allantoin were topically administered for 14 days and the wound area was evaluated by planimetry and by qualitative and quantitative histological analysis of open wound model. Results:The data which were obtained and analyzed innovate by demonstrating, qualitatively and quantitatively, by histological analysis, the profile of healing process induced by allantoin. The results suggest that the wound healing mechanism induced by allantoin occurs via the regulation of inflammatory response and stimulus to fibroblastic proliferation and extracellular matrix synthesis. Conclusion: This work show, for the first time, the histological wound healing profile induced by allantoin in rats and demonstrated that it is able to ameliorate and fasten the reestablishment of the normal skin. Key words: Wound Healing. Allantoin. Histology. Animal Experimentation. Rats. RESUMOObjetivo: Avaliar e caracterizar o perfil cicatricial induzido pela alantoína incorporada em uma emulsão óleo/água, sob os aspectos planimétrico e histológico. Métodos: Ratos Wistar fêmeas (n=60) foram agrupados aleatoriamente em três grupos experimentais grupo controle -sem tratamento (C); grupo tratado com emulsão pura (E); grupo tratado com emulsão contendo 5% de alantoína (EA). As emulsões contendo ou não alantoína foram administradas topicamente durante 14 dias e a área da ferida foi avaliada por planimetria e por análise histológica qualitativa e quantitativa em modelo de ferida aberta. Resultados: Na análise planimétrica não foi observado diferenças significativas entre os grupos experimentais. Os resultados da análise histológica sugerem que o mecanismo de cicatrização induzido pela alantoína ocorre via controle da resposta inflamatória e estímulos à proliferação fibroblástica e síntese de matrix extracelular de maneira mais intensa e rapidamente em relação aos grupos controles. Conclusão: Este trabalho mostra pela primeira vez o perfil histológico de cicatrização induzido pela alantoína em ratos, demonstrando ser capaz de melhorar e acelerar o processo de reconstituição da pele. Descritores: Cicatrização de Feridas. Alantoína. Histologia. Experimentação Animal. Ratos.

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Section: Histological Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Profile of wound healing process induced by allantoin

et al. 2010

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“…"Comfrey" (Symphytum officinale L.) was found with four herbalists, who indicated the ingestion of a tea made from this plant for liver problems, gastritis, ulcers, etc. This species has additional proven medicinal effects, including wound-healing, anti-irritant activity, and moisturizing effects due to the presence of allantoin and mucilage (Ritter et al, 2002) although studies have proven that when used internally for long periods of time, this plant can cause veno-occlusive diseases, especially of the liver, provoking late hepatic cirrhosis and cancer due to the cumulative effect of pyrrolizidinic alkaloids (Saito and Oliveira, 1986;Ferro, 1989;Parente and Rosa, 2001). "Arruda" (Ruta graveolens L.) was cited in this study as a treatment for earaches, strokes, and late menstruation, yet it contains metilnonilcetone, which can provoke abortions.…”

Section: Toxicity Of Medicinal Plants Sold In Traditional Marketsmentioning

confidence: 99%

Medicinal and magic plants from a public market in northeastern Brazil

Albuquerque

Monteiro

Ramos

et al. 2007

Journal of Ethnopharmacology

264

158

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“…It is noted that allantoin, which is found in plants like chamomile, wheat sprouts, sugar beet, and comfrey, has been widely used in anti-aging serum [ 85 , 86 ]. Allantoin is also a well-known anti-irritating and hydrating agent as well as a peeling agent for skin [ 87 , 88 ].…”

Section: Discussionmentioning

confidence: 99%

Multiple-Molecule Drug Design Based on Systems Biology Approaches and Deep Neural Network to Mitigate Human Skin Aging

2021

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Human skin aging is affected by various biological signaling pathways, microenvironment factors and epigenetic regulations. With the increasing demand for cosmetics and pharmaceuticals to prevent or reverse skin aging year by year, designing multiple-molecule drugs for mitigating skin aging is indispensable. In this study, we developed strategies for systems medicine design based on systems biology methods and deep neural networks. We constructed the candidate genomewide genetic and epigenetic network (GWGEN) via big database mining. After doing systems modeling and applying system identification, system order detection and principle network projection methods with real time-profile microarray data, we could obtain core signaling pathways and identify essential biomarkers based on the skin aging molecular progression mechanisms. Afterwards, we trained a deep neural network of drug–target interaction in advance and applied it to predict the potential candidate drugs based on our identified biomarkers. To narrow down the candidate drugs, we designed two filters considering drug regulation ability and drug sensitivity. With the proposed systems medicine design procedure, we not only shed the light on the skin aging molecular progression mechanisms but also suggested two multiple-molecule drugs for mitigating human skin aging from young adulthood to middle age and middle age to old age, respectively.

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Confrei: virtudes e problemas

Cited by 7 publications

References 0 publications

Profile of wound healing process induced by allantoin

Profile of wound healing process induced by allantoin

Medicinal and magic plants from a public market in northeastern Brazil

Multiple-Molecule Drug Design Based on Systems Biology Approaches and Deep Neural Network to Mitigate Human Skin Aging

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