Mudanças na concentração plasmática de zinco e ácido fólico em adolescentes grávidas submetidas a diferentes esquemas de suplementação

Abstract

Zinc and folic acid nutritional status was evaluated in 74 low-income pregnant adolescents ranging from 13 to 18 years of age who received prenatal care at the Evangelina Rosa Maternity Hospital in Teresina, Piau State, Brazil. In order to evaluate the effects of different supplementation regimens on nutritional status, the adolescents were distributed into five groups. Groups I and II received equal amounts of folic acid (250 micro;g) and different doses of iron (ferrous sulfate), 120 and 80 mg, respectively. Groups III and IV received equal amounts of folic acid (250 micro;g) associated with zinc sulfate and iron at doses of 120 and 80 mg, respectively, while group V received only 120 mg of iron (routine dosage). There was a reduction in the zinc plasma concentration, and this decline was significant only in those groups which did not receive zinc supplementation. In relation to combination iron/folic acid and iron/folic acid/zinc, an excellent response was observed for folic acid, and this effect was larger in the groups that received folic acid combined with zinc, suggesting a possible role for zinc in folic acid metabolism.

Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis

“…Ten studies included women in childbearing age, three were on pregnant women [33–35] and two included lactating women [20, 36]. Placebo was used in the control group in the majority of studies except for two studies [27, 33] in which the control group did not undergo any treatment.…”

“…Placebo was used in the control group in the majority of studies except for two studies [27, 33] in which the control group did not undergo any treatment. Only one study included pregnant adolescents [35]. Most of the trials (i.e., ten) were conducted in Europe, two in New Zealand [24, 32], one was in Brazil [35], one in Canada [36], and one in the USA [20].…”

Perfil Socioeconômico De Gestantes Cadastradas Em Uma Unidade De Saúde Do Município De Criciúma

“…Realizado com 74 adolescentes grávidas entre 13 e 18 anos, que encontravam-se no período de 16 a 20 semanas de gravidez, concluiu-se que o uso de 80mg e 120mg de ferro em adolescentes grávidas provoca similar melhora na resposta hemoglobínica, porém, não interfere na reserva do ferro, podendo estar associado ou não ao ácido fólico e ao zinco (NOGUEIRA; PARENTE; COZZOLINO, 2003).…”

Associação da deficiência de ácido fólico com alterações patológicas e estratégias para sua prevenção: uma visão crítica

“…Nogueira et al 36 avaliaram o estado nutricional do AF e zinco, bem como o impacto nas concentrações plasmáticas desses micronutrientes, após diferentes esquemas de suplementação, em 74 gestantes adolescentes brasileiras. Nesse estudo, as gestantes foram aleatoriamente distribuídas em cinco grupos.…”

“…Verificou-se que 37% e 79% das gestantes adolescentes apresentaram concentrações plasmá-ticas reduzidas de AF e zinco respectivamente. O uso combinado de ferro/AF e ferro/AF/zinco promoveu a melhora da deficiência do AF, sendo esse efeito mais expressivo nos grupos que receberam AF associado ao zinco, o que suge-re uma possível participação do zinco no aproveitamento dessa vitamina 36 .…”