Epidemiologia dos acidentes ofídicos nos últimos 100 anos no Brasil: uma revisão

Bochner, Rosany; Struchiner, Cláudio J.

doi:10.1590/s0102-311x2003000100002

Cited by 108 publications

(119 citation statements)

References 12 publications

(20 reference statements)

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“…5 Little difference in the frequency of accidents with spiders and scorpions was observed when comparing men and women. This is probably because most cases of this type of poisoning occur in urban areas and in houses where these animals are found.…”

Section: Discussionmentioning

confidence: 98%

“…The epidemiological profile of snakebite victims is a rural male worker between the ages of 15 to 49, usually affected on the lower limbs. 5,6 The lethality of snakebite is 0.44%, 4 and there is an association between the severity of cases and age (children under 10 years and older adults experience the worst consequences). [7][8][9] The scorpions of medical interest in Brazil belong to the genus Tityus; three main species are responsible for serious, even fatal, poisonings in humans in the South, Southeast, Midwest and Northeast Brazil 6,10 : T. bahiensis (brazilian scorpion), T. serrulatus (yellow scorpion) and T. stigmurus.…”

Section: Introductionmentioning

confidence: 99%

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Accidents With Poisonous Animals in Brazil by Age and Sex

Silva

Bernarde

Abreu

2015

J. Hum. Growth Dev.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Accidents With Poisonous Animals in Brazil by Age and Sex

Silva

Bernarde

Abreu

2015

J. Hum. Growth Dev.

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“…The increased number of snakebites during the rainy period has also been observed in other northeastern regions of Bazil (7) (8) , as well as in the northern region (9) . Similarly, studies regarding the epidemiology of snakebites in the southern (10) and southeastern (11) regions have reported a higher incidence of snakebites during the rainy period, although the rainy season in these regions occurs between October and April. Table 1 shows that the majority of snakebites occurred in rural areas (n = 1,276; 83.5%), and involved men (n = 1,200; 78.5%), people with low levels of education (n = 1,052; 68.8%), or people who were 30-39 years old (n = 277; 18.1%).…”

mentioning

confidence: 91%

The epidemiology of envenomation via snakebite in the State of Piauí, Northeastern Brazil

Oliveira

Sousa

Belmino

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Introduction: This communication describes a retrospective study of the epidemiology of snakebite cases that were recorded from 2007 to 2012 in the State of Piauí, northeastern Brazil. Methods: Data were collected from the Injury Notifi cation Information System database of the State of Piauí's Health Department. Results: A total of 1,528 cases were identifi ed. The cases occurred most frequently in rural areas between January and July. Victims were predominantly male farmers, and were typically 30-39 years old. Most victims were bitten on the foot, and received medical assistance within 1-3h after being bitten. Conclusions:The epidemiological profi le of snakebites in the State of Piauí is similar to that in all of Brazil.

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“…Bothrops jararaca is a snake of the viperidae family, largely distributed in Brazil and responsible for 90% of the ophidian envenomations in humans (Bochner & Struchiner 2003). Trypanosoma cruzi is the agent of Chagas disease affecting 16-18 million people in Latin America.…”

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confidence: 99%

Programmed cell death in Trypanosoma cruzi induced by Bothrops jararaca venom

Deolindo

Teixeira-Ferreira

Melo

et al. 2005

Mem. Inst. Oswaldo Cruz

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Cells die through a programmed process or accidental death, know as apoptosis or necrosis, respectively. Bothrops jararaca is a snake whose venom inhibits the growth ofIn multicellular organisms, programmed cell death (PCD), also known as apoptosis, is important to control cell number for proper development and tissue homeostasis, removal of unwanted cells and functional control of the immune, haemopoietic and nervous systems (Welburn et al. 1997). The process of PCD is activated by genetically controlled cell suicide machinery (Ameisen 1996). In vertebrate cells, PCD can be activated by external stimuli (ethanol, reactive oxygen species, and receptor ligands) and internal processes (mitotic catastrophe, replication failures, developmental programmed cell death) (Fröhlich & Madeo 2000). PCD is also a common response to cell stress caused by different toxins (Vaux 2002). Independent of the stimulus, PCD usually involves alteration in the mitochondrial membrane permeability, caspase activation, phosphatidylserine (PS) exposure, nuclear and cytoplasmic condensation, DNA fragmentation and breakage of the cell into apoptotic bodies, which are engulfed by the surrounding cells (Vaux & Strasser 1996). PCD is a process found in virtually all nucleated metazoan cells, and it has been recently associated with several species of unicellular eukaryotes, notably kinetoplastids (Ameisen et al. 1995, Welburn et al. 1996, Moreira et al. 1996 (Picot et al. 1997, Peng et al. 2003, and amitochondrion parasites (Chose et al. 2002, Mariante et al. 2003.Snake venoms have been identified as the richest source of enzymes among poisonous animal, displaying a variety of biological activities (Tan & Ponnudurai 1992). Bothrops jararaca is a snake of the viperidae family, largely distributed in Brazil and responsible for 90% of the ophidian envenomations in humans (Bochner & Struchiner 2003). Trypanosoma cruzi is the agent of Chagas disease affecting 16-18 million people in Latin America. We have previously demonstrated that B. jararaca venom inhibited the growth of epimastigote forms of T. cruzi, causing mitochondrion swelling and kinetoplast disorganization (Gonçalves et al. 2002). Because of the ultrastructural alteration observed in the mitochondrion after venom treatment it was suggested that impairment of this organelle was probably responsible for growth inhibition (Gonçalves et al. 2002). However, how epimastigotes were demising was not analyzed. Thus, the aim of the present work was to identify if PCD or necrosis was being induced in T. cruzi epimastigote forms during B. jararaca venom treatment. MATERIALS AND METHODSParasite and venom -Epimastigote forms of T. cruzi (Y strain) were maintained at 28°C by weekly transfers in liver infusion tryptose (LIT) medium (Camargo 1964) supplemented with 10% fetal bovine serum (FBS). Fourday-old cultured epimastigote forms (mid-log phase) were used for the experiments. 34 34 34 3 4 Cell death by snake venom • Poliana Deolindo et al.Lyophilized B. jararaca venom was purchased from the Instit...

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Epidemiologia dos acidentes ofídicos nos últimos 100 anos no Brasil: uma revisão

Cited by 108 publications

References 12 publications

Accidents With Poisonous Animals in Brazil by Age and Sex

Accidents With Poisonous Animals in Brazil by Age and Sex

The epidemiology of envenomation via snakebite in the State of Piauí, Northeastern Brazil

Programmed cell death in Trypanosoma cruzi induced by Bothrops jararaca venom

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