Is pertussis actually reemerging? Insights from an individual-based model

Codeço, Cláudia Torres; Luz, Paula M.

doi:10.1590/s0102-311x2001000300005

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Asymptomatic and mild infections are becoming increasingly studied in mathematical modelling (Codeco and Luz, 2001;Fouchet et al, 2006Fouchet et al, , 2007Grenfell, 2003, 2004;Gomes et al, 2004;Mossong and Muller, 2003). Here, using the example of the rabbit-myxomatosis interaction, we show that attenuated infections can have important consequences for the host population.…”

Section: Impact Of a Disease Potentially Attenuated By Maternal Antibmentioning

confidence: 83%

Impact of myxomatosis in relation to local persistence in wild rabbit populations: The role of waning immunity and the reproductive period

Fouchet

Guitton

Marchandeau

et al. 2008

Journal of Theoretical Biology

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Section: Impact Of a Disease Potentially Attenuated By Maternal Antibmentioning

confidence: 83%

Impact of myxomatosis in relation to local persistence in wild rabbit populations: The role of waning immunity and the reproductive period

Fouchet

Guitton

Marchandeau

et al. 2008

Journal of Theoretical Biology

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“…For the sake of simplicity, we have not considered some features of the host-parasite interaction. One is the possibility of recovered individuals becoming re-infected, a feature that is receiving increasing attention (Codeco & Luz 2001;Glass & Grenfell 2003, 2004Mossong & Muller 2003;Gomes et al 2004). In our context, waning of acquired immunity could be a very important factor.…”

Section: Discussionmentioning

confidence: 97%

The role of maternal antibodies in the emergence of severe disease as a result of fragmentation

Fouchet

Marchandeau

Bahi-Jaber

et al. 2006

J. R. Soc. Interface.

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Population fragmentation is a major problem for the conservation of mammalian species. Since the spread of an infectious disease is related to the intensity of contacts between individuals, fragmentation destabilizes the way the parasites circulate in their host population. Recently, Zinkernagel has proposed that a reduction in the frequency of infections by a parasite could lead to the emergence of severe forms of the disease, previously avoided because the disease was contracted early in life and attenuated by maternal antibodies. However, it is still unclear whether this change in disease expression increases the global mortality it induces because the disease becomes more severe and also less frequent. Here, we use a mathematical model to link population fragmentation with the hypothesis of Zinkernagel. Firstly, we show that there is a change in the severity of the disease during the fragmentation process, especially at a local scale, suggesting that host population fragmentation could be a widespread mechanism of disease emergence. Secondly, we show that the emergence of the severe form of the disease can lead to a significant increase in its induced mortality. Finally, we determine the types of interactions for which the fragmentation of the host population could be the most dangerous.

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Avaliação de novas estratégias vacinais contra a coqueluche no município de São Paulo

Freitas¹

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Uma parte de mim é todo mundo: outra parte é ninguém: fundo sem fundo. Uma parte de mim é multidão: outra parte estranheza e solidão. Uma parte de mim pesa, pondera: outra parte delira. Uma parte de mim é permanente: outra parte se sabe de repente. Uma parte de mim é só vertigem: outra parte, linguagem. Traduzir-se uma parte na outra parte-que é uma questão de vida ou morteserá arte? FERREIRA GULLAR TRADUZIR-SE Descritores: coqueluche; vacina contra coqueluche; adolescentes, adultos; modelos teóricos. Freitas AC. Avaliação de novas estratégias vacinais contra coqueluche no município de São Paulo. / Whooping cough-theoretical evaluation of new vaccination strategies in São Paulo-Brazil [dissertation]. São Paulo:

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Is pertussis actually reemerging? Insights from an individual-based model

Cited by 3 publications

References 15 publications

Impact of myxomatosis in relation to local persistence in wild rabbit populations: The role of waning immunity and the reproductive period

Impact of myxomatosis in relation to local persistence in wild rabbit populations: The role of waning immunity and the reproductive period

The role of maternal antibodies in the emergence of severe disease as a result of fragmentation

Avaliação de novas estratégias vacinais contra a coqueluche no município de São Paulo

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