Impact of myxomatosis in relation to local persistence in wild rabbit populations: The role of waning immunity and the reproductive period

Fouchet, David; Guitton, Jean-Sébastien; Marchandeau, Stéphane; Pontier, Dominique

doi:10.1016/j.jtbi.2007.10.037

Cited by 17 publications

(26 citation statements)

References 52 publications

(60 reference statements)

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“…Our study confirms that rabbit populations respond very differently in terms of host survival and epidemiological dynamics when exposed to MV and RHDV, even if geographically close to each other [51,52]. Multiple interacting causes likely explain this heterogeneity.…”

Section: Discussionsupporting

confidence: 74%

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Multi-event capture–recapture modeling of host–pathogen dynamics among European rabbit populations exposed to myxoma and Rabbit Hemorrhagic Disease Viruses: common and heterogeneous patterns

Santoro

Pacios

Moreno

et al. 2014

Vet Res

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Host–pathogen epidemiological processes are often unclear due both to their complexity and over-simplistic approaches used to quantify them. We applied a multi-event capture–recapture procedure on two years of data from three rabbit populations to test hypotheses about the effects on survival of, and the dynamics of host immunity to, both myxoma virus and Rabbit Hemorrhagic Disease Virus (MV and RHDV). Although the populations shared the same climatic and management conditions, MV and RHDV dynamics varied greatly among them; MV and RHDV seroprevalences were positively related to density in one population, but RHDV seroprevalence was negatively related to density in another. In addition, (i) juvenile survival was most often negatively related to seropositivity, (ii) RHDV seropositives never had considerably higher survival, and (iii) seroconversion to seropositivity was more likely than the reverse. We suggest seropositivity affects survival depending on trade-offs among antibody protection, immunosuppression and virus lethality. Negative effects of seropositivity might be greater on juveniles due to their immature immune system. Also, while RHDV directly affects survival through the hemorrhagic syndrome, MV lack of direct lethal effects means that interactions influencing survival are likely to be more complex. Multi-event modeling allowed us to quantify patterns of host–pathogen dynamics otherwise difficult to discern. Such an approach offers a promising tool to shed light on causative mechanisms.

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Section: Discussionsupporting

confidence: 74%

“…This indicates that rabbits can lose immunity to these diseases (albeit with a very low probability). The effect of sex on the rate at which individuals became seropositive varying among populations further illustrates the varying behavior of these diseases across individuals and populations [51,52]. …”

Section: Discussionmentioning

confidence: 99%

Multi-event capture–recapture modeling of host–pathogen dynamics among European rabbit populations exposed to myxoma and Rabbit Hemorrhagic Disease Viruses: common and heterogeneous patterns

Santoro

Pacios

Moreno

et al. 2014

Vet Res

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“…Mills et al 1997Mills et al , 1999Borucki et al 2000;Escutenaire et al 2000;Calisher et al 2007;Dearing et al 2009). However, their role in infection dynamics has largely been neglected in studies on hantaviruses and on natural populations generally, despite recent acknowledgement of the potential of MatAbs to influence disease dynamics in wildlife populations through altering the amount of susceptible individuals (Gasparini et al 2001;Staszewski et al 2007;Bouliner & Staszewski 2008), and their recent inclusion in theoretical studies (Fouchet et al 2006(Fouchet et al , 2007(Fouchet et al , 2008.…”

Section: Introductionmentioning

confidence: 99%

Hantavirus infections in fluctuating host populations: the role of maternal antibodies

Kallio

Begon

Henttonen³

et al. 2010

Proc. R. Soc. B.

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Infected females may transfer maternal antibodies (MatAbs) to their offspring, which may then be transiently protected against infections the mother has encountered. However, the role of maternal protection in infectious disease dynamics in wildlife has largely been neglected. Here, we investigate the effects of Puumala hantavirus (PUUV)-specific MatAbs on PUUV dynamics, using 7 years' data from a cyclic bank vole population in Finland. For the first time to our knowledge, we partition seropositivity data from a natural population into separate dynamic patterns for MatAbs and infection. The likelihood of young of the year carrying PUUV-specific MatAbs during the breeding season correlated positively with infection prevalence in the overwintered parent population in the preceding spring. The probability of PUUV infection varied between seasons (highest in spring, lowest in late summer) and depended on population structure, but was also, in late autumn, notably, negatively related to summer MatAb prevalence, as well as to infection prevalence earlier in the breeding season. Hence, our results suggest that high infection prevalence in the early breeding season leads to a high proportion of transiently immune young individuals, which causes delays in transmission. This suggests, in turn, that MatAb protection has the potential to affect infection dynamics in natural populations.

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“…The main results for the classical SIS and SIR epidemic models can be found in several textbooks (Andersson and Britton, 2000;Allen, 2003;Bailey, 1990;Daley and Gani, 1999). For discussions about variants and generalizations, please consult some recent papers (Allen, 2008;Clancy, 2005;Fouchet et al, 2008;Lindholm, 2008;Xu et al, 2007) and the references therein.…”

Section: Applications To Stochastic Population Modelsmentioning

confidence: 99%

“…A good reference to find the underlying mathematical theory is the textbook by Allen (2003) and its references. As examples of recent applications of continuous-time Markov chains in population biology, we mention some papers published in this journal (Casagrandi and Gatto, 2006;Fouchet et al, 2008;Stirk et al, 2008;Xu et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Quasi-stationary and ratio of expectations distributions: A comparative study

Artalejo

Lopez-Herrero

2010

Journal of Theoretical Biology

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Abstract. Many stochastic systems, including biological applications, use Markov chains in which there is a set of absorbing states. It is then needed to consider analogues of the stationary distribution of an irreducible chain. In this context, quasi-stationary distributions play a fundamental role to describe the long-term behavior of the system. The rationale for using quasi-stationary distribution is well established in the abundant existing literature. The aim of this study is to reformulate the ratio of means approach Seneta, 1965, 1967) which provides a simple alternative. We have a two-fold objective. The first objective is viewing quasi-stationarity and ratio of expectations as two different approaches for understanding the dynamics of the system before absorption. At this point, we remark that the quasi-stationary distribution and a ratio of means distribution may give or not give similar information. In this way, we arrive to the second objective; namely, to investigate the possibility of using the ratio of expectations distribution as an approximation to the quasistationary distribution. This second objective is explored by comparing both distributions in some selected scenarios, which are mainly inspired in stochastic epidemic models. Previously, the rate of convergence to the quasi-stationary regime is taking into account in order to make meaningful the comparison.

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Impact of myxomatosis in relation to local persistence in wild rabbit populations: The role of waning immunity and the reproductive period

Cited by 17 publications

References 52 publications

Multi-event capture–recapture modeling of host–pathogen dynamics among European rabbit populations exposed to myxoma and Rabbit Hemorrhagic Disease Viruses: common and heterogeneous patterns

Multi-event capture–recapture modeling of host–pathogen dynamics among European rabbit populations exposed to myxoma and Rabbit Hemorrhagic Disease Viruses: common and heterogeneous patterns

Hantavirus infections in fluctuating host populations: the role of maternal antibodies

Quasi-stationary and ratio of expectations distributions: A comparative study

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