Toxicidade do pericarpo da Jatropha curcas em ovinos

Ferreira, O.R.; Brito, S.S.; Lima, Flávia Gontijo de; Souza, Domenica Palomaris Mariano de; Mendonça, Simone; Ribeiro, José Antônio de Aquino; Maiorka, Paulo César; Araújo, Vera Lúcia de; Neiva, José Neuman Miranda; Fioravante, Maria Clorinda Soares; Ramos, Adriano Tony; Maruo, Viviane Mayumi

doi:10.1590/s0102-09352012000300006

Cited by 4 publications

(6 citation statements)

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“…These changes are indicative of hepatic injury suffered by animals fed with JC. Increased concentrations of these enzymes from protein catabolism corroborate results reported by Mariz et al (2006) and Ferreira et al (2012).…”

Section: Discussionsupporting

confidence: 88%

“…Similar inhaled descriptions were found in rats treated with leaf extract of Jatropha gassypiifolia (MARIZ et al, 2006). In sheep submitted to pericarp feeding of J. Curcas, it was verified that the animals presented intoxication, characterized by cachexia, diarrhea, hypocortical mucosae, dehydration, alopecia, bradypnea, crackling respiration (FERREIRA et al, 2012). Developmental effects of rats fed with diet containing Jatropha defatted grains promoted serious pathological symptoms causing death with the concentration of phorbol esters of 47.31 mg.kg -1 body mass (RAKSHIT et al, 2008).…”

Section: Discussionsupporting

confidence: 73%

“…Congestion of hepatic sinusoids was observed in rats submitted to the dose of 26.4 mg.kg-¹ of jatropha (LI et al, 2010). Similar changes, such as congestion, lymphoplasmacytic and histiocytic periportal infiltrate, centrilobular vacuolar hepatic degeneration, and mild to moderate cholestasis, were observed in sheep liver (FERREIRA et al, 2012). Histopathological changes were observed by the reduction of the cytoplasm and nucleus, according to the increase of the inclusion of JC.…”

Section: Discussionmentioning

confidence: 57%

“…The inclusion of the pericarp of J. Curcas in the sheep diet promoted dose-dependent reduction in feed intake and was attributed to the association of several toxic compounds present in the plant (FERREIRA et al, 2012). However, in an experiment where only the most toxic compound (phorbol ester) was absent, these other substances did not affect consumption or performance in sheep (OLIVEIRA et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Torta de pinhão-manso (Jatropha curcas): implicações hepatotóxicas

Honorato

Silva

Flores-Quintana

et al. 2017

Braz. J. Vet. Res. Anim. Sci.

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Jatropha has been highlighted as an oleaginous potential for the production of biofuel. The cake, produced by oil extraction, could be used in animal feed. However, some varieties of jatropha are toxic by limiting their incorporation into animal diets. The objective of this study was to evaluate the hepatotoxicity of diets added with jatropha cake -JC (Jatropha curcas) in rats. Thirty-five (35) male Wistar adults rats (Rattus norvegicus) with initial weight of 352.1 ± 26.8 g were used. The animals were fed for 21 days with the diets: control, 10, 25, 40 and 50% JC. In the feeding with 50% JC the animals presented themselves prostrate and with piloerection. Development and survival decreased, since the inclusion of JC in diets increased. In rats submitted to 10 and 25% JC there was an increase of 17.52% in the hepatosomatic index in relation to the control group. Increase of JC in the rat diet promoted an increase in the activity of ALT and AST enzymes. Anatomic-histopathological evaluation demonstrated that, regardless of the levels tested, JC in rat diet causes hypertrophy of the hepatocytes, with a reduction in energy reserves. This study demonstrated that the use of JC resulted in decreased food intake, associated with weight loss due to the clinical pattern of toxicity, demonstrated by biochemical and histopathological changes in the liver. It was concluded that the inclusion of jatropha cake in rat feeding presents high hepatotoxic potential leading to lesions in the liver parenchyma. Keywords: Toxic. The hepatotoxicity. Animal feed. ResumoO pinhão-manso tem se destacado como oleaginosa potencial para a produção de biocombustível. A torta, coproduto da extração do óleo, poderia ser utilizada na alimentação animal. No entanto, algumas variedades de pinhão-manso são tóxicas, limitando sua incorporação em dietas animais. Objetivou-se neste estudo avaliar a hepatotoxicidade de dietas acrescidas de torta de pinhão-manso (Jatropha curcas) em ratos. Foram utilizados trinta e cinco (35) ratos Wistar (Rattus norvergicus) machos adultos com peso inicial de 352,1 ± 26,8 g. Os animais foram alimentados por 21 dias com as dietas: controle, 10, 25, 40 e 50% TPM. Na alimentação com 50% TPM os animais apresentaram-se prostrados e com piloereção. O desenvolvimento e a sobrevivência apresentaram diminuição conforme o aumento da inclusão de TPM nas dietas. Em ratos submetidos a 10 e 25% TPM houve aumento de 17,52% no índice hepatossomático em relação ao grupo controle. O aumento de TPM na dieta de ratos promoveu aumento da atividade das enzimas ALT e AST. A avaliação anatomo-histopatológica revelou que, independentemente dos níveis testados, a TPM na alimentação de ratos provoca hipertrofia dos hepatócitos, com redução das reservas energéticas. Este estudo demonstrou que a utilização de TPM resultou em diminuição do consumo de alimento associado à perda de peso devido ao quadro clínico de toxicidade demonstrado pelas alterações bioquímica e histopatológica no fígado. Conclui-se que a inclusão de torta de pinhão-manso ...

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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Torta de pinhão-manso (Jatropha curcas): implicações hepatotóxicas

Honorato

Silva

Flores-Quintana

et al. 2017

Braz. J. Vet. Res. Anim. Sci.

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“…Abdalla et al (2008) avaliaram a substituição do farelo de soja do concentrado por tortas de pinhão-manso e observaram uma redução na produção total de gases e de metano em relação ao grupo controle a partir de 50% de inclusão, teor de torta superior em pouco mais de duas vezes ao testado neste estudo. Já em estudos realizados in vivo, foram observados efeitos tóxicos nos animais mesmo com a utilização de tortas parcialmente destoxificadas em teores similares aos máximos valores utilizados neste bioensaio, ou com teores de ingestão de ésteres de forbol inferiores a maioria dos valores de adição realizados neste bioensaio (KATOLE et al, 2011;FERREIRA et al, 2012).…”

Section: Análise Deunclassified