Uso tópico de ketanserina na cicatrização de feridas cutâneas induzidas em equinos

Ribeiro, G.; Martins, Carla Braga; Silva, M. A. G.; Borges, Vanderci; Neto, J. C. Lacerda

doi:10.1590/s0102-09352009000100020

Cited by 8 publications

(9 citation statements)

References 6 publications

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“…Complete re-epithelialization was already present in all wounds treated with PRP, similar to the description in the study by Bauer et al 27 However, at M17, the microscopic analysis of samples from the treated group revealed the presence of inflammatory cells consistent with the initial phase (inflammatory) of healing 19 . Similarly, on the basis of an analysis of synovial fluid, Yamada et al 14 concluded that treatment of joint lesions with PRP did not significantly minimize the degree of inflammation compared to saline solution.…”

Section: Discussionsupporting

confidence: 86%

“…According to Ribeiro et al 19 , factors responsible for promoting tissue hypergranulation include lesion location, mobility of the region, altered tissue perfusion, infections, and trauma. Corroborating the justification pointed out by the authors, since none of the above factors was present, it is possible to understand why hypergranulation was not observed in this study.…”

Section: Discussionmentioning

confidence: 99%

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Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits

et al. 2015

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Intellectual and scientific content of the study, surgical procedures, critical revision. ABSTRACT PURPOSE:To evaluate the potential of heterologous platelet-rich plasma (PRP) gel for surgical skin wound healing in rabbits METHODS: Blood from a single healthy dog was used for PRP production, with calcium gluconate added to the PRP to form the gel.Two surgical excisions, one to the right and the other to the left of the dorsal midline, were made in six rabbits. One side was randomly allocated to topical application of a physiological solution, and the other was allocated to treatment with heterologous PRP gel. Clinical assessments (weight, pain sensitivity, coloring, edema, hyperemia, exudation, crust, and granulation) and morphometric evaluations were performed 0, 3, 7, 10, 14, and 17 days postoperatively. Histological analysis was performed on the 17 th day. RESULTS:With the exception of the presence of a crust at day 10, clinical variables did not differ significantly between the experimental groups. In both the control and PRP-treated groups, differences were identified when comparing time-points in terms of wound area reduction. Histological results indicated no significant differences between the control group and the PRP-treated group. CONCLUSION:Heterologous platelet-rich plasma gel promoted dermal wound healing in rabbits with no adverse effects.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits

et al. 2015

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“…The area was then calculated using the following mathematical equation described by Prata et al (1988): A=π × R × r, where A = area of the wound, R = larger radius, and r = smaller radius. The calculation of the wound contraction rate was expressed by the formula used by Ribeiro et al (2009): Af-Ai/Ai × 100, where Ai = initial wound area (M0) and Af = final wound area (M17).…”

Section: Macroscopic and Morphometric Analysismentioning

confidence: 99%

Collagen quantification in rabbit dermal wounds treated with heterologous platelet-rich plasma gel

Marques

Laposy

Silva

et al. 2017

SCA

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Platelet-rich plasma (PRP) has been extensively studied as a biomaterial for wound treatment, and the heterologous PRP is usefulin the event that obtaining the patient’s own blood is impossible. This study aimed to evaluate and compare wound healing in rabbits and quantify the collagen in experimentally induced wounds in a control group and in a group treated with heterologous PRP gel. We hypothesize that this gelis capable of promoting proper healing with no adverse reactions, increased collagen content. The clinical aspects of coloring, edema, hyperemia, exudation, crust, granulation, pain sensitivity, and retraction index of the wounds were measuredon days 7, 14, and 17 after the injury. Collagen quantification by Picrosirius staining and evaluation under polarized light was performed on the 17th day. Crust was present in both groups at all evaluated time points, with the absence of other clinical signs. The wound contraction rate and collagen quantity did not differ between groups. In conclusion, the suggested hypothesis was partially confirmed; the heterologous PRP gel was unable to increase the amount of collagen and accelerate the wound healing process, however, wound healing was efficient and similar in both groups and there was no local adverse reaction. Thus, despite the scarcity of studies in the literature, the heterologous PRP gel is an effective alternative treatment for wounds in the absence of other sources of PRP.

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“…17,18 The percentage of contraction of the wound was calculated using a mathematical model where the percentage of contraction (Pc) equalled the final area (Af) minus the initial area (Ai) times 100 ( Â 100) divided by the initial area (Ai), in other words: Pc ¼ (Af -Ai) Â 100/Ai. 19 In each case the wound was photographed with a digital camera (Nikon Õ ; Nikon Corp, Tokyo, Japan).…”

Section: Morphometric Evaluationsmentioning

confidence: 99%

Comparison of experimentally-induced wounds in rabbits treated with different sources of platelet-rich plasma

et al. 2015

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Over the years, autologous platelet-rich plasma (PRP) has been used to great advantage in the healing of acute and chronic wounds. However, it is impossible to use in some situations so alternative PRPs need to be considered, such as homologous or heterologous PRPs. In order to evaluate the effects of PRP in the form of autologous, heterologous and homologous gels on in vivo cutaneous wound healing, 18 animals divided into three groups of six, were used for the study, with another six animals used as PRP donors. For the heterologous group an adult, mixed breed dog was used to obtain the PRP. The wounds were induced using an 8 mm punch. The left side was treated with NaCl 0.9%® (A) and a PRP gel was applied (GA = autologous; GHE = heterologous and GHO = homologous) on the right side (B). The wounds were evaluated for a period of 17 days. On the 17th day biopsies were taken for histopathological assessment of the wounds. The percentage of contraction was evident in side B (treated), which was confirmed in the microscopic analysis of the histological sections. Thus, it was concluded that PRP, regardless of the source, improves and accelerates the healing process, demonstrating its therapeutic potential on cutaneous lesions and its use in patients with impaired wound healing.

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Uso tópico de ketanserina na cicatrização de feridas cutâneas induzidas em equinos

Cited by 8 publications

References 6 publications

Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits

Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits

Collagen quantification in rabbit dermal wounds treated with heterologous platelet-rich plasma gel

Comparison of experimentally-induced wounds in rabbits treated with different sources of platelet-rich plasma

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