Conjugated linoleic acid supplementation: lipid content and hepatic histology in healthy Wistar rats

Santos-Zago, Lilia Ferreira; Botelho, Adriana Prais; Oliveira, Admar Costa de; Maróstica, Mário Roberto

doi:10.1590/s0101-20612011000100020

Cited by 3 publications

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References 31 publications

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“…The supplementation with PSO 4% resulted in an increase in lipid content of the liver. Santos-Zago et al, [31] showed that the levels of lipids in the liver of rats supplemented with CLAs did not differ significantly from the control group, but it can be observed that there was an increase of fat globules in the livers of animals supplemented with CLAs, as shown by tissue histopathology. The histological pattern of cell organelles was not changed.…”

Section: Resultsmentioning

confidence: 94%

Effect of Pomegranate (Punica granatum L.) Seed Oil on Markers of Oxidative Stress Induced by Carbon Tetrachloride in Wistar Rats

Ilp¹,

Amo²,

Ebt³

et al. 2015

IJFS

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The pomegranate seed oil (PSO) presents a high content of the punicic acid (PA), which is a conjugated isomer of α-linolenic acid (CLNA). Conjugated fatty acids have increasingly attracted scientific interest because of their several potential health benefits, including antioxidant activity. The aim of this study was to evaluate the supplementation effect of PSO on oxidative stress markers in rats subjected to liver injury by carbon tetrachloride (CCl 4 ). Animals were supplemented with PSO at concentrations of 2% and 4%, for 21 days, and then subjected to liver injury induced by CCl 4 . The PSO supplementation reduced serum aminotransferase enzymes and the percentage of liver damage induced by CCl 4 . Conversely, PSO supplementation increased the lipid hydroperoxides levels in the liver. Overall, these results suggest that supplementation with PSO is not capable of attenuating markers of oxidative stress caused by CCl 4 .

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Section: Resultsmentioning

confidence: 94%