Meningiomas em cães: aspectos clínicos, histopatológicos e imuno-histoquímicos

Marcasso, Rogério Anderson; Moreira, Jéssica R.; Valentim, Larissa Garbelini; Arias, Mônica Vicky Bahr; Bracarense, Ana Paula Frederico Rodrigues Loureiro

doi:10.1590/s0100-736x2015001000005

Cited by 9 publications

(26 citation statements)

References 45 publications

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“…Meningiomas em cães são descritos comumente no Pastor Alemão (Patnaik et al 1986, Montoliu et al 2006, Boxer (Montoliu et al 2006, Petersen et al 2008, Vandevelde et al 2012, Golden Retriever (Petersen et al 2008, Vandevelde et al 2012, Labrador (Petersen et al 2008, Poodle (Marcasso et al 2015), Collie (Petersen et al 2008) e Terriers (Song et al 2013). Neste estudo, cães de raça foram os mais acometidos, sendo que a raça Boxer (31,8%) foi a mais representada, seguida pelo Pastor Alemão (18,1%).…”

Section: Discussionunclassified

“…Devido a sua cronicidade, as neoplasias causam sinais neurológicos progressivos (Summers et al 1995). Com relação à localização intracraniana, os sinais de alteração tálamo-cortical (65%) foram os mais frequentes, como previamente observado (Costa 2009, Marcasso et al 2015, e foram caracterizados principalmente por convulsão (76,9%). Crise convulsiva é a manifestação neurológica mais frequente em cães com neoplasmas encefálicos de qualquer origem (Bagley & Gavin 1998, Snyder et al 2006, Costa 2009).…”

Section: Discussionunclassified

“…Os meningiomas intraespinhais causaram com maior frequência sinais de ataxia proprioceptiva, déficit de propriocepção e paresia/paraplegia. Independentemente do segmento medular afetado, a localização e a extensão da lesão é que determinarão a dificuldade locomotora do animal, podendo variar de monoparesia a tetraplegia (Santos et al 2012, Costa 2009, Marcasso et al 2015.…”

Section: Discussionunclassified

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Graduação histológica e aspectos clínico-patológicos relacionados em 22 meningiomas de cães

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Intracranial and supratentorial meningiomas were the most frequent in relation to the other intracranial or intraspinal sites. The intracranial ones were characterized mainly by clinical signs of thalamic-cortical alteration. Intraspinal ones were mainly characterized by ataxia. G-I meningiomas were the most frequent (63.6%) in dogs, followed by G-III (22.7%) and G-II (13.6%). GI were characterized by having the psammomatous subtype as the most frequent, more than one morphological pattern in the same tumor, one third presenting areas of invasion of nervous tissue, 71.4% of cases involving females, a mean age of 11 years, pure breed dogs as the most affected ones and for having the longest survival time after the manifestation of clinical signs. G-II meningiomas were characterized by having the chordoid subtype as the most frequent, invasion of nervous tissue in one third of cases, only females affected, a mean age of 12 years, two-thirds of the dogs affected were mongrels and the maximum survival time of 20 days. The G-III meningiomas were characterized by having the papillary subtype as the most frequent, invasion of the nervous tissue in 80% of the cases, 60% of the cases involving females, a mean age of 8 years, 80% of dogs affected were Boxers and the maximum survival time of 90 days. In conclusion, this study allowed to establish a relationship between the three histological grades observed in 22 cases of meningiomas in dogs with various clinical-epidemiological and pathological parameters, providing useful information for a better understanding of the correlation between the histological grading and the clinical evolution of these neoplasms.

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Section: Discussionunclassified

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Graduação histológica e aspectos clínico-patológicos relacionados em 22 meningiomas de cães

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“…A etiologia para ocorrência das neoplasias intracranianas não são totalmente esclarecidas; porém a dieta, o ambiente, trauma craniano, fatores genéticos, imunológicos, químicos e virais podem predispor ao aparecimento (Marcasso et al, 2015). Teixeira (2015) em seu estudo relata que as raças de maior predisposição para o meningioma incluem o pastor alemão, Colie, Golden Retriever, Labrador Retriever e Boxer.…”

Section: Introductionunclassified

“…Geralmente, animais portadores de neoplasia intracranianos apresentam um aparecimento gradual dos sinais clínicos (Marcasso et al, 2015, Carvalho et al, 2017. O principal sinal clínico encontrado em um quadro de menigioma são as convulsões focais ou generalizadas (Silva et al, 2014, Marcasso et al, 2015, edema, hidrocefalia e hemorragia podem ocorrer na forma secundária a doença.…”

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Canine meningioma: Case report

Pereira¹,

Pessoa²,

Sousa³

et al. 2018

Pubvet

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RESUMO.O meningioma é a neoplasia intracraniana mais comum em cães na clínica veterinária, em maior parte dos casos possui caráter benigno, além disso, pode vir a surgir em qualquer uma das três meninges que revestem e protegem o sistema nervoso central. O principal sinal clínico do meningioma é a convulsão, porém alteração de comportamento vem sendo relatada com frequência na literatura. A lomustina por ser altamente solúvel em lipídeos, atinge elevadas concentrações no fluido cérebro-espinhoso permitindo que a mesma seja usada como protocolo quimioterápico para pacientes com meningioma. Objetivou-se com esse trabalho, relatar um caso de meningioma intracraniano em um cão de raça poodle com dez anos de idade destacando sua evolução clínica, diagnóstico presuntivo e conduta terapêutica. Palavras chave: convulsão, lomustina, neoplasia intracranianaCanine meningioma: Case report ABSTRACT. Meningioma is the most common intracranial neoplasia in dogs in the veterinary clinic, in most cases it has a benign nature, and may arise in any of the three meninges that cover and protect the central nervous system. The main clinical sign of meningioma is seizure, but behavioral alterations have been reported frequently in the literature. Lomustine, because it is highly soluble in lipids, reaches high concentrations in the brain-spinal fluid allowing it to be used as a chemotherapeutic protocol for patients with meningioma. The objective of this work was to report a case of intracranial meningioma in a poodle dog at the age of ten, highlighting its clinical evolution, presumptive diagnosis and therapeutic behavior. Keywords: convulsion, lomustine, intracranial neoplasiaMeningioma canino: Reporte de un caso RESUMEN. El meningioma es la neoplasia intracraneal más común en perros en la clínica veterinaria, en la mayoría de los casos tiene carácter benigno, además, puede surgir en cualquiera de las tres meninges que revisten y protegen el sistema nervioso central. La principal señal clínica del meningioma es la convulsión, pero alteración de comportamiento viene siendo reportada con frecuencia en la literatura. La lomustina por ser altamente soluble en lípidos, alcanza altas concentraciones en el fluido cerebro-espinoso permitiendo

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Spinal cord anaplastic meningioma with extra-neural metastasis in a cat

et al. 2018

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Meningiomas are the most frequent neoplasms involving the brain in dogs and cats, and are occasionally observed in the spinal cord. They cause compression of the central nervous system; however, do not infiltrate the neuropile and rarely metastasize to other organs. The present study describes a case of anaplastic spinal meningioma with extra neural metastasis in a 20 years-old cat. Clinically, the feline presented a clinical history of 120 days with paresis of the hind limbs and loss of the tail’s movements, with subsequent death. At necropsy, there was an irregular and soft whitish mass involving the meninges from the lumbar intumescence to the sacral region of the spinal cord. Similar white nodular masses were observed in the lungs, liver and kidneys. Microscopically, both were composed of a poorly limited and infiltrative neoplastic proliferation composed by spindle, round and epithelioid cells, with a high cellular pleomorphism. On IHC, there was a severe immunostaining for vimentin and S100. Histopathologic and IHC analysis are important tools for definitive diagnosis of meningiomas in cats, and differentiation of other common neurologic disorders in these animals.

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Meningiomas em cães: aspectos clínicos, histopatológicos e imuno-histoquímicos

Cited by 9 publications

References 45 publications

Graduação histológica e aspectos clínico-patológicos relacionados em 22 meningiomas de cães

Graduação histológica e aspectos clínico-patológicos relacionados em 22 meningiomas de cães

Canine meningioma: Case report

Spinal cord anaplastic meningioma with extra-neural metastasis in a cat

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