Graduação histológica e aspectos clínico-patológicos relacionados em 22 meningiomas de cães

Abstract

Intracranial and supratentorial meningiomas were the most frequent in relation to the other intracranial or intraspinal sites. The intracranial ones were characterized mainly by clinical signs of thalamic-cortical alteration. Intraspinal ones were mainly characterized by ataxia. G-I meningiomas were the most frequent (63.6%) in dogs, followed by G-III (22.7%) and G-II (13.6%). GI were characterized by having the psammomatous subtype as the most frequent, more than one morphological pattern in the same tumor, one third presenting areas of invasion of nervous tissue, 71.4% of cases involving females, a mean age of 11 years, pure breed dogs as the most affected ones and for having the longest survival time after the manifestation of clinical signs. G-II meningiomas were characterized by having the chordoid subtype as the most frequent, invasion of nervous tissue in one third of cases, only females affected, a mean age of 12 years, two-thirds of the dogs affected were mongrels and the maximum survival time of 20 days. The G-III meningiomas were characterized by having the papillary subtype as the most frequent, invasion of the nervous tissue in 80% of the cases, 60% of the cases involving females, a mean age of 8 years, 80% of dogs affected were Boxers and the maximum survival time of 90 days. In conclusion, this study allowed to establish a relationship between the three histological grades observed in 22 cases of meningiomas in dogs with various clinical-epidemiological and pathological parameters, providing useful information for a better understanding of the correlation between the histological grading and the clinical evolution of these neoplasms.

Increased frequency of pneumonia in dogs with meningioma in ventral rhombencephalon

“…CN invasion and, occasionally, compression were identified in VR group dogs with pneumonia, commonly presenting with related clinical signs. A retrospective study showed that CNs V, VII, IX, X, and XII dysfunction was observed in 16.7% of dogs with intracranial meningioma (Areco et al 2018). CN dysfunction was the most common clinical sign after convulsive crisis, absent thalamocortical reactions, altered consciousness or behavior, and circling behavior.…”

“…It may present with an altered state of consciousness, seizures, and vestibular dysfunction (Motta et al 2012). Like many other neurological deficits, the clinical signs commonly reflect neuroanatomical tumor distribution (Areco et al 2018). A suitable example would be neurogenic swallowing disorders following cranial nerve (CN) deficits due to posterior fossa or skull base tumors (McCulloch & Jaffe 2006, Finsterer & Grisold 2015, Kumar et al 2017.…”