Desenvolvimento de um método reflectométrico ambientalmente mais amigável para a determinação de metoclopramida em formulações farmacêuticas

Abstract

Recebido em 4/3/09; aceito em 29/7/09; publicado na web em 21/1/10 DEVELOPMENT OF AN ENVIRONMENTALLY MORE BENIGN REFLECTOMETRIC METHOD FOR THE DETERMINATION OF METOCLOPRAMIDE IN PHARMACEUTICAL FORMULATIONS. A simple and more environmentally friendly method by combined spot test-diffuse reflectance spectroscopy for determining metoclopramide in pharmaceutical formulations is described. The method is based on the reaction between metoclopramide and p-dimethylaminocinnamaldehyde, in the presence of HCl, producing a colored compound (l máx = 580 nm) on the filter paper. The linear range was from 5.65 x 10-4-6.21x10-3 mol L-1 (r = 0.999). The limit of detection was 1.27 x 10-4 mol L-1. The proposed reflectometric method was applied successfully to the determination of metoclopramide in pharmaceuticals and it was favorably compared with the Brazilian or British Pharmacopoeia methods at 95% confidence level.