Cyclic voltammetry and differential pulse voltammetry were utilized to evaluate Hydralazine hydrochloride (HHC), a direct-acting vasodilator type of medication which relaxes blood arteries and boosts the flow of blood and oxygen to the heart. Blood pressure symptoms are common and the usage of these drugs is increasing. Utilizing a sodium dodecyl sulphate at synthesized graphitic carbon nitride carbon paste electrode (SDS@g-C3N4-BCPE) for the electro sensing of HHC. For the evaluation of electrode electrochemical impedance spectroscopy, scanning electron microscopy (SEM), atomic force microscopy, and energy-dispersive X-ray (EDX) analysis were used. The low-cost synthesis of graphitic carbon nitride (g-C3N4) was characterized using X-ray diffraction, Fourier transform infrared spectroscopy, and SEM with EDX. Under different phosphate buffer solutions, the HHC demonstrates one oxidation peak between -0.4 to 0.7 V potential, with pH 7.0 yielding the best results. An electro-oxidation mechanism been postulated as a possible route. The DPV was used to perform a quantitative examination of HHC. The linearity range was determined between 0.8 -10µM. The LOD and LOQ were 1.9 x 10-8 M and 6.5 x 10-8 M, correspondingly, and outperformed previous approaches. Furthermore, the novel process was employed to determine the concentrations of HHC in biological, pharmaceutical and water samples.
A novel sensor PVA capped Mn-doped ZnS incorporated MoS2 nanosheet composite modified gold electrode (PVA-Mn:ZnS/MoS2@GE) has been developed for the determination of acebutolol (ACB). Cyclic voltammetry (CV) and square wave voltammetry (SWV) were used to measure the electrochemical performance of ACB. Use of the nanocomposite PVA-Mn:ZnS/MoS2 as a modifier in electrode-based sensors results in well-resolved peaks and improved electrochemical current sensitivity compared to a bare gold electrode. Using the SWV technique in pH 7.0 phosphate buffer, the examination of samples of biological, environmental, and tablet spiked with ACB was monitored, the limit of detection and quantification is found to be 0.38x10-9 M and 1.28x10-9 M respectively. CV, energy dispersive X-ray, scanning electron microscopy, and impedance spectroscopy were performed to characterize the electrode material. A suitable mechanism was proposed for the number of protons and electrons involved in the redox reaction of ACB.
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