Sensitive and selective voltammetric oxidation and determination of an antiemetic drug using gold electrode and its biomedical applications

A sensitive square‐wave voltammetry (SWV) method based on basal‐plane pyrolytic graphite electrode (BPPGE) and edge‐plane pyrolytic graphite electrode (EPPGE) was developed to determine the concentration of the pesticide mandipropamid (MAN) in spiked river water and grape juice samples. Under optimal experimental conditions, the SWV response of EPPGE and BPPGE was linear over the concentration ranges of 0.7 to 9.0 μmol L−1 and 0.5 to 10.0 μmol L−1, respectively. The method was successfully used to determine MAN in spiked samples with good recovery. Cyclic voltammetry (CV) was conducted to understand the mechanism underlying the electrode process of MAN.

show abstract

“…The resultant quaternary Schiff base was rapidly hydrolyzed. These types of oxidation mechanisms have been proposed in earlier reports [30].…”

Section: Of Man Involves Varying Numbers Of Protons and Electronsmentioning

confidence: 60%

A Comparison of Edge‐plane and Basal‐plane Pyrolytic Graphite Electrodes towards Sensitive Determination of the Fungicide Mandipropamid

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The limit of detection (LOD) (S/N = 3) was estimated to be 0.0075 μmol/L. [41] The comparison between the analytical performance of the developed method on the P-PGE and some reported electrochemical methods for determination of rapamycin is given in Table 2.…”

Section: Quantification Of Rapamycinmentioning

confidence: 99%

Development of a voltammetric method for the determination of rapamycin in pharmaceutical samples at pretreated pencil graphite electrode

Karaboduk

2021

J Chinese Chemical Soc

View full text Add to dashboard Cite

This paper describes an electroanalytical method for the determination of rapamycin using a pretreated pencil graphite electrode (P‐PGE) by differential pulse voltammetry. The electrodes were successfully characterized by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electron microscopy, and Fourier transform infrared. The influences of instrumental and chemical parameters were investigated and optimized for the determination of rapamycin. Oxidation peak current obtained for rapamycin at P‐PGE was 10.5 times higher than that obtained for PGE. In pH = 3.0 H3PO4, a well‐defined irreversible anodic peak occurred at 1.07 V, which was attributed to the electro‐oxidation of rapamycin at P‐PGE. Under optimized conditions, the oxidation peak current of rapamycin was linear with its concentration in the range of 0.01–250 μmol/L, and the detection limit was 0.0075 μmol/L (S/N = 3). Also, the P‐PGE exhibited good reproducibility (relative SD [RSD] = 2.17% for 10 electrodes at different times using the same procedure), repeatability (RSD = 2.09% for 10 measurements with same electrode), and stability (95.80% for 10 days). The P‐PGE was simple to prepare and the method was successfully applied for the determination of rapamycin in spiked and real samples. In addition, for comparison, high‐performance liquid chromatographic method with ultraviolet (UV) detector was used for the determination of rapamycin.

show abstract

“…There are many different techniques that have been used for the determination of metoclopramide by various methods, including spectrophotometric methods [6,15], HPLC [16][17][18][19][20][21], potentiometric [22], Densitometric and UPLC methods [23], fluorometric [24], Flow Injection Chemiluminescence Technique [25], voltammetric [26], electrochemiluminescence [27],Capillary electrophoresis [28],LC-MS/MS [29], Atomic Absorbance [30] and molar refraction and polarizability method [31]. The main aim of the current work is to suggest an accurate and sensitive visible spectrophotometric method for the assay of METH as pure and in dosage form via oxidative…”

Section: Introductionmentioning

confidence: 99%

Using of Oxidative - Coupling Reaction in Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Preparations

Yassin

2022

basjs

View full text Add to dashboard Cite

A simple, sensitive, and rapid spectrophotometric method has been developed for the determination of metoclopramide hydrochloride (METH). The method includes the oxidative coupling reaction of metoclopramide with 2,5-dihydroxybenzoic acid using potassium periodate as an oxidizing agent in an aqueous medium and at pH of 4.5 to give a water-soluble colored product. The highest absorbance occurs at a wavelength of 500 nm. The linear range of Beer's law was within the concentration range of 5-75 µg/ml of (METH) and the value of the molar absorptivity 2.196 x103 l.mol-1.cm-1 and Sandell's index value was equal to 0.0449 µg/ cm2. The relative standard deviation value was ≤ 2.98, while the LOD and LOQ values were 0.059 µg.ml-1 and 0.198 µg.ml-1 respectively. The proposed method was successfully applied in the spectrophotometric estimation of metoclopramide preparations in the form of tablets and injections with acceptable recovery.

show abstract

Sensitive and selective voltammetric oxidation and determination of an antiemetic drug using gold electrode and its biomedical applications

Cited by 7 publications

References 35 publications

A Comparison of Edge‐plane and Basal‐plane Pyrolytic Graphite Electrodes towards Sensitive Determination of the Fungicide Mandipropamid

A Comparison of Edge‐plane and Basal‐plane Pyrolytic Graphite Electrodes towards Sensitive Determination of the Fungicide Mandipropamid

Development of a voltammetric method for the determination of rapamycin in pharmaceutical samples at pretreated pencil graphite electrode

Using of Oxidative - Coupling Reaction in Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Preparations

Contact Info

Product

Resources

About