Dimensões do granuloma hepático produzido por ovos de duas linhagens geográficas do Schistosoma mansoni, no camundongo

Coelho, Paulo Marcos Zech; Raso, Pedro; Mello, Rodrigo Fernandes de; Toppa, Nivaldo Hartung

doi:10.1590/s0074-02761989000200009

Cited by 6 publications

(6 citation statements)

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“…Our measurements of hepatic granulomas differed from those obtained by Carvalho et al (1986), Coelho et al (1989), and Domingo and Warren (1968), presumably due to factors such the immunological reaction of the host to different strains, number of cercariae used to infected mice, different dates of sacrifice, and differing method of measuring the granulomas. Andrade and Warren (1964) and Raso (2000) described granulomas as initially bulky, with intense cellularity (predominently macrophages, lymphocytes, and eosinophyls); later, the exudate decreases and is substituted by conjunctive tissue until the formation of a fibroid nodule.…”

Section: Discussioncontrasting

confidence: 90%

“…In these authors study, however, healthy mice were not used. Coelho et al (1989) made the same observation and recorded a notable reduction in the dimensions of granulomatous reactions at 12 weeks p.i.…”

Section: Discussionsupporting

confidence: 52%

“…The experimental infection by Schistosoma mansoni in laboratory animals has been frequently used as a model for the analysis of pathological and physiopathological studies in human infection (Andrade et al 1985, Carvalho et al1986, Coelho et al 1989, Cheever et al 2002.…”

mentioning

confidence: 99%

“…Some experiments have used a Puerto Rico strain (Andrade et al 1985). In Brazil, each investigator uses his regional strain and it is frequently necessary to compare the results of studies with Puerto Rico and Brazilian strains (Andrade et al 1985, Coelho et al 1989. The paucity of studies in the Amazonian area prompted the following investigation, with the objective of describing the histopathological findings at different phases of experimental infection by two strains PC (PA) and LILA (MA) of S. mansoni in laboratory mice.…”

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confidence: 99%

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Histopathological study of Schistosoma mansoni infection in the murine model using the PC (Pará) and LILA (Maranhão) strains

Lopes

Santos

Souza

et al. 2006

Mem. Inst. Oswaldo Cruz

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Experimental models of Schistosoma mansoni infections in mammals have contributed greatly in understanding the pathology and pathogenesis of human infection. The absence of earlier reviews regarding specific strains of the Amazon region prompted research, which the main objective was to describe histopathological lesions in different phases of schistosomiasis in a murine model using PC (Pará) and LILA (Maranhão) S. mansoni strains. One hundred and eighty young female albino swiss mice (Mus musculus) were used and were randomly divided into five groups and controls), according to the number of cercariae injected and the strain adopted. Animals were sacrificed in predetermined periods (35, 56, 112, 156, and 180 days) in an attempt to follow the evolution of the disease in the histological sections of their tissues at different phases of infection. Our findings were compatible with the data already described by others authors using different strains of S. mansoni, making it possible to identify some peculiarities, which are discussed in this work. In conclusion, the strains of parasite used did not modify the histopathological findings in the tissues of infected mice in any significant way when compared with the results of other studies using different strains.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionsupporting

confidence: 52%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Histopathological study of Schistosoma mansoni infection in the murine model using the PC (Pará) and LILA (Maranhão) strains

Lopes

Santos

Souza

et al. 2006

Mem. Inst. Oswaldo Cruz

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“…The diverse behavior of different strains of Schistosoma mansoni [4–11] may account for the regional variation observed in clinical schistosomiasis [12]. The degree of morbidity in human schistosomiasis varies regionally, possibly due to variations in parasite infectivity and fecundity [13].…”

Section: Introductionmentioning

confidence: 99%

A Study of the Granulomatous Responses Induced by Different Strains ofSchistosoma mansoni

Zuim

Allegretti

Linhares

et al. 2012

Interdisciplinary Perspectives on Infectious Diseases

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The increased pathogenesis of the Schistosoma mansoni BH strain compared with the SJ strain has been attributed to the number of granulomas formed in experimental infections, which increase the mortality in definitive hosts. The aim of the present study was to investigate the development of granulomas around the eggs of the S. mansoni BH and SJ strains and to determine whether this host reaction was strain specific. Four experimental groups were analyzed. Two groups contained mice inoculated in the caudal vein with eggs from the S. mansoni BH or SJ strains and the other two contained mice that were infected with cercariae of the BH strain prior to being inoculated with eggs. The number of granulomas per tissue area in the lungs and liver, as well as the size of the granulomas, was analyzed to characterize the response to schistosome infection. The largest granulomatous responses were observed around eggs of the BH strain. Granulomas covered a larger area in the lungs of mice that were previously infected with cercariae and subsequently inoculated with eggs of the BH strain. These results indicated that specific granulomatous responses occurred following an infection with the BH and SJ strains of S. mansoni.

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No evidence for schistosome parasite fitness trade-offs in the intermediate and definitive host

et al. 2023

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Background The trematode parasite Schistosoma mansoni uses an aquatic snail intermediate and a vertebrate definitive host to complete its life cycle. We previously showed that a key transmission trait—the number of cercariae larvae shed from infected Biomphalaria spp. snails—varies significantly within and between different parasite populations and is genetically controlled by five loci. We investigated the hypothesis that the success of parasite genotypes showing high propagative fitness in the intermediate snail host may be offset by lower reproductive fitness in the definitive vertebrate host. Methods We investigated this trade-off hypothesis by selecting parasite progeny producing high or low number of larvae in the snail and then comparing fitness parameters and virulence in the rodent host. We infected inbred BALB/c mice using two Schistosoma mansoni parasite lines [high shedder (HS) and low shedder (LS) lines] isolated from F2 progeny generated by genetic crosses between SmLE (HS parent) and SmBRE (LS parent) parasites. We used the F3 progeny to infect two populations of inbred Biomphalaria glabrata snails. We then compared life history traits and virulence of these two selected parasite lines in the rodent host to understand pleiotropic effects of genes determining cercarial shedding in parasites infecting the definitive host. Results HS parasites shed high numbers of cercariae, which had a detrimental impact on snail physiology (measured by laccase-like activity and hemoglobin rate), regardless of the snail genetic background. In contrast, selected LS parasites shed fewer cercariae and had a lower impact on snail physiology. Similarly, HS worms have a higher reproductive fitness and produced more viable F3 miracidia larvae than LS parasites. This increase in transmission is correlated with an increase in virulence toward the rodent host, characterized by stronger hepato-splenomegaly and hepatic fibrosis. Conclusions These experiments revealed that schistosome parasite propagative and reproductive fitness was positively correlated in intermediate and definitive host (positive pleiotropy). Therefore, we rejected our trade-off hypothesis. We also showed that our selected schistosome lines exhibited low and high shedding phenotype regardless of the intermediate snail host genetic background. Graphical Abstract

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Dimensões do granuloma hepático produzido por ovos de duas linhagens geográficas do Schistosoma mansoni, no camundongo

Cited by 6 publications

References 0 publications

Histopathological study of Schistosoma mansoni infection in the murine model using the PC (Pará) and LILA (Maranhão) strains

Histopathological study of Schistosoma mansoni infection in the murine model using the PC (Pará) and LILA (Maranhão) strains

A Study of the Granulomatous Responses Induced by Different Strains ofSchistosoma mansoni

No evidence for schistosome parasite fitness trade-offs in the intermediate and definitive host

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