Correlação entre a cistatina C sérica e marcadores de aterosclerose subclínica em pacientes hipertensos

Monteiro, Francisco das Chagas; Ferreira, Pedro Antônio Muniz; Nunes, Jorge Luiz Silva; Júnior, Cacionor Pereira da Cunha; Brito, Ronald Lopes; Costa, João Henrique Almeida; Lima, José Ribamar; Lages, Joyce Santos; Filho, Natalino Salgado; Lima, Valter Correia de

doi:10.1590/s0066-782x2012005000083

Cited by 12 publications

(8 citation statements)

References 43 publications

(61 reference statements)

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“…Results of the present study overlap with a previous study that examined how serum cystatin C, which is an endogenous filtration marker for eGFR, related to estimated CVD risk (using the Framingham score), IMT and FMD in a cross-sectional study of 103 adults with hypertension and a mean measured creatinine clearance of 94.8 ± 43.3 mL/min/1.73 m 2 [ 16 ]. Similar to our study, the investigators found that higher CVD risk was associated with poorer kidney function, and also found a strong, inverse association between IMT and FMD.…”

Section: Discussioncontrasting

confidence: 43%

“…Compared with our sample of US adults, participants in the study conducted by Monteiro Junior et al were Brazilian, older in age (57 versus 52 years), predominantly non-white (64% versus 40%), treated with antihypertensive medications and had higher clinic SBPs (145 versus 137 mmHg). The cohort also included patients with diabetes (16% versus 0%) and creatinine clearance <60 mL/min/1.73 m 2 (18% versus 0%), and had a higher mean IMT (1.09 mm versus 0.70 mm) [ 16 ]. Results from other studies examining how serum cystatin C relates to IMT and/or FMD have been inconsistent [ 17–19 ].…”

Section: Discussionmentioning

confidence: 99%

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Association between normal or mildly reduced kidney function, cardiovascular risk and biomarkers for atherosclerosis: results from the ENCORE trial

Tyson

Smith

Mabe

et al. 2017

Clinical Kidney Journal

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BackgroundModerate-to-severe kidney dysfunction is associated with atherosclerotic cardiovascular disease (ASCVD). Gradations of normal or mildly reduced kidney function may also associate with ASCVD risk.MethodsWe conducted a secondary analysis using baseline data from the Exercise and Nutritional Interventions for Cardiovascular Health (ENCORE) trial. Participants were sedentary, overweight and obese adults with unmedicated pre-hypertension or Stage I hypertension and an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2. The Pooled Cohorts Equations were used to estimate a 10-year risk for first ASCVD event. Carotid artery intima-media thickness (IMT) and brachial artery flow-mediated dilation (FMD) were measured to assess subclinical atherosclerosis and vascular endothelial function, respectively. Using linear regression, we examined the association between eGFR and ASCVD risk, IMT and FMD.ResultsParticipants (N = 139) were predominantly women (65%), white (60%), with a mean age of 52.0 ± 9.6 years and mean eGFR of 89.1 ± 15.0 mL/min/1.73 m2. Lower eGFR of 15 mL/min/1.73 m2 was associated with higher ASCVD risk [b = −2.7% (95% confidence interval: −3.7, −1.8%), P < 0.001], higher IMT [b = 0.05 mm (0.03, 0.08 mm), P < 0.001] and lower FMD [b = −0.87% (−1.64, −0.11%), P = 0.026]. Compared with eGFR ≥90 mL/min/1.73 m2, those with eGFR 60–89 mL/min/1.73 m2 had higher mean ASCVD risk (7.6% versus 2.7%; P < 0.001), greater mean IMT (0.74 mm versus 0.66 mm; P < 0.001) and lower mean FMD (2.0% versus 3.7%; P = 0.026). After controlling for CVD risk factors, the association between eGFR and IMT remained significant (P < 0.001), and eGFR and FMD trended toward significance (P = 0.08).ConclusionsAmong overweight and obese adults with unmedicated high blood pressure and eGFR ≥60 mL/min/1.73 m2, lower eGFR is associated with a greater 10-year risk for first ASCVD event, higher IMT and relatively impaired FMD.

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Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Association between normal or mildly reduced kidney function, cardiovascular risk and biomarkers for atherosclerosis: results from the ENCORE trial

Tyson

Smith

Mabe

et al. 2017

Clinical Kidney Journal

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“…Kidney injury can be detected by decreased GFR and/or proteinuria. Previous studies show that CysC is capable of detecting mild and moderate kidney damage 4-7 , and research has been conducted to evaluate whether CysC can also be considered a cardiovascular risk factor independently of renal function 8-10 . …”

Section: Discussionmentioning

confidence: 99%

“…Previous research has suggested that CysC is an alternative to creatinine to estimate glomerular filtration rate, especially to detect early-stage renal dysfunction 4-7 . Recent reports suggest that CysC can predict the risk of death and cardiovascular events independently of renal function 8-10 . …”

Section: Introductionmentioning

confidence: 99%

Cystatin C, CRP, Log TG/HDLc and Metabolic Syndrome are Associated with Microalbuminuria in Hypertension

Moura¹,

Vasconcelos²,

Freitas³

et al. 2013

Arquivos Brasileiros De Cardiologia

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Background In patients with systemic hypertension, microalbuminuria is a marker of endothelial damage and is associated with an increased risk for cardiovascular disease. Objective To determine the factors that may lead to the occurrence of microalbuminuria in hypertensive patients with serum creatinine lower than 1.5 mg/dL. Methods This cross-sectional study included 133 Brazilians with essential hypertension followed up at a hypertension outpatient clinic. Those with serum creatinine higher than 1.5 mg/dL, as well as those with diabetes mellitus, were excluded. Systolic and diastolic blood pressures were measured, and body mass index (BMI) and GFR estimated by using the CKD-EPI formula were calculated. The serum levels of the following were assessed: CysC, creatinine, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, C-reactive protein (CRP) and fasting glucose. Microalbuminuria was determined in 24-hour urine. Hypertensive patients were classified according to the presence of one or more criteria for metabolic syndrome. Results In a multiple regression analysis, the serum levels of CysC and CRP, the atherogenic index log TG/HDLc and the presence of three or more criteria for metabolic syndrome were positively correlated with microalbuminuria (r2: 0.277, p < 0.05). Conclusion CysC, CRP, log TG/HDLc, and the presence of three or more criteria for metabolic syndrome, regardless of serum creatinine, were associated with microalbuminuria, an early marker of kidney damage and cardiovascular risk in patients with essential hypertension.

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“…У больных с острым инфарктом миокарда концентрация цистатина С в плазме крови оказалась значимо выше, чем у пациентов со стабильной или нестабильной стенокардией. кроме того, при дальнейшем наблюдении в течение 6 месяцев развитие сердечно-сосудистых осложнений ассоциировалось с более высокими плазматическими уровнями цистатина С. Отмечается также, что у пожилых больных независимо от наличия или отсутствия ХБП цистатин С является биомаркером повышенного риска развития сердечно-сосудистых событий и отражает тяжесть коронарной болезни сердца [46,47]. Отдельные исследования показали непосредственную связь цистатина С и артериальной гипертензии.…”

Section: цистатин с и сердечно-сосудистые заболеванияunclassified

Сystatin C potential use in the diagnosis of various diseases

et al. 2018

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The prevalence of chronic kidney disease (CKD) is increasing worldwide. It leads to a high risk of cardiovascular disease, early disability and mortality. The severity of CKD is determined by the level of reduction in glomerular filtration rate (GFR). Modern formulas for calculating GFR based on serum creatinine give errors. The search for new informative methods of evaluation of GFR is an urgent task. A number of studies have shown the effectiveness of cystatin C determination in serum as a more sensitive indicator of GFR decline for early detection of renal pathology. The timely detection of diabetic nephropathy and the administration of nephroprotective and cardioprotective therapy is an important task in reducing the risk of cardiovascular disease and mortality. This review article discusses the possibility of using cystatin C as a marker of renal function decline, diagnosis of cardiovascular disease, and the development of preeclampsia. (For citation: Glavnova OB, Yarmolinskaya MI, Syslova SV, Borovik NV. Сystatin C potential use in the diagnosis of various diseases. Journal of Obstetrics and Women’s Diseases. 2018;67(4):40-47. doi: 10.17816/JOWD67440-47).

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Correlação entre a cistatina C sérica e marcadores de aterosclerose subclínica em pacientes hipertensos

Abstract: In middle-aged hypertensive outpatients, s-CC correlated with measured creatinine clearance, as expected, but no association was observed with markers of atherosclerosis neither with established cardiovascular risk factors.

Cited by 12 publications

References 43 publications

Association between normal or mildly reduced kidney function, cardiovascular risk and biomarkers for atherosclerosis: results from the ENCORE trial

Association between normal or mildly reduced kidney function, cardiovascular risk and biomarkers for atherosclerosis: results from the ENCORE trial

Cystatin C, CRP, Log TG/HDLc and Metabolic Syndrome are Associated with Microalbuminuria in Hypertension

Сystatin C potential use in the diagnosis of various diseases

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