Сystatin C potential use in the diagnosis of various diseases

Abstract

The prevalence of chronic kidney disease (CKD) is increasing worldwide. It leads to a high risk of cardiovascular disease, early disability and mortality. The severity of CKD is determined by the level of reduction in glomerular filtration rate (GFR). Modern formulas for calculating GFR based on serum creatinine give errors. The search for new informative methods of evaluation of GFR is an urgent task. A number of studies have shown the effectiveness of cystatin C determination in serum as a more sensitive indicator of GFR decline for early detection of renal pathology. The timely detection of diabetic nephropathy and the administration of nephroprotective and cardioprotective therapy is an important task in reducing the risk of cardiovascular disease and mortality. This review article discusses the possibility of using cystatin C as a marker of renal function decline, diagnosis of cardiovascular disease, and the development of preeclampsia. (For citation: Glavnova OB, Yarmolinskaya MI, Syslova SV, Borovik NV. Сystatin C potential use in the diagnosis of various diseases. Journal of Obstetrics and Women’s Diseases. 2018;67(4):40-47. doi: 10.17816/JOWD67440-47).