Fatores genéticos na agregação familiar da pressão arterial de famílias nucleares portuguesas

Fermino, Rogério César; Seabra, André; Garganta, Rui; Maia, José

doi:10.1590/s0066-782x2009000300008

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…Moreover in selected populations the role of genetic factors appears to be likely predominant with respect to the environment 23, 24 . However the specific weight of familiarity is still underestimated for confounding factors in the general population.…”

Section: Discussionmentioning

confidence: 99%

The possible role of chromosome X variability in hypertensive familiarity

et al. 2016

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Familiarity participates in the pathogenesis of hypertension, although only recently, whole genome studies have proposed regions of the human genome possibly involved in the transmission of the hypertensive phenotype. While studies have mainly focused on autosome, hitherto the influence of sex on familial transmission of hypertension has not been considered. We analyzed the database of the Campania Salute Network of Hypertension center of the Federico II University Hospital of Naples (Italy), using dichotomous variables for paternal and maternal familiarity and gender (male and female) of 12,504 hypertensive patients (6,868 males and 5,636 females) and 6,352 controls (3,484 males and 2,868 females), totaling 18,856 subjects. In the hypertensive group, familiarity was present in 75% of cases with odds of 3.77 and in only 26% of the normotensives with odds of 0.94. The odds ratio (OR) indicated that familiarity increases the risk of developing hypertension by 2.91 (95% CI = 2.67 – 3.17, p < 0.001) times. Additionally, maternal familiarity was 37% (OR = 3.01, 95% CI = 2.66 – 3.41, p < 0.001), paternal familiarity was 21% (OR = 2.31, 95% CI = 2.01 – 2.68, p < 0.001), and the double familiarity was 17% (OR = 3.45, 95% CI = 2.87 – 4.01, p < 0.001), thus suggesting a plausible association between maternal familiarity and development of hypertension; this finding was observed both in male and female patients, although the phenomenon was larger in males. Given the dominance of maternal transmission in males, by genome-wide analysis of the X chromosome, we found 2 regions that were differently distributed in male hypertensives with maternal hypertension. Our data highlights the importance of genetic variants in the X chromosome to the maternal transmission of the hypertensive phenotype.

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Section: Discussionmentioning

confidence: 99%

The possible role of chromosome X variability in hypertensive familiarity

et al. 2016

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“…Previous studies have shown the greatest absolute BMI increase was within the already heaviest population [33], and only a moderate amount of SBP and DBP is accounted for by genetic factors [34], indicating the unignorable large impact of shared environment. Recently, Brown et al further added that, based on a US sibling cohort, sharing the same household could facilitate the social network influence on correlations in BMI [35].…”

Section: Discussionmentioning

confidence: 99%

Familial correlation and aggregation of body mass index and blood pressure in Chinese Han population

et al. 2013

BMC Public Health

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BackgroundIt remains unclear whether the body mass index (BMI) and blood pressure (BP) profile are clustered within families in Chinese Han population. The aim of this study is to explore familial aggregation and parent-offspring correlations of BMI and blood pressure in Chinese Han population.Methods6,369 Han nucleus families, consisting of parents and at least one biological adult child who were living together, were enrolled from the nation-wide cross-sectional study (China National Nutrition and Health Survey) which was conducted in 2002, with a total number of 19,107 participants aged 18–64 years (6,369 sets of parents, 4,132 sons and 2,237 daughters). Family aggregation (Intra-class correlations, ICCs) and parent-offspring correlations in BMI, systolic BP (SBP) and diastolic BP (DBP) were estimated using linear mixed effect regression models.ResultsBMI and BP levels in two generations and ICCs of BMI, SBP and DBP varied across the country. Familial aggregation of overweight/obesity was observed in rural area (ICC = 5.4%, p<0.05), and high BP (defined as SBP ≥ 120 mmHg or DBP ≥ 80 mmHg) was more common in low income families (ICC = 4.4%, p<0.05) compared to middle income (ICC = 1.9%) and high income families (ICC = 2.6%). Additionally, offspring with more parents being overweight/obese tend to have higher BMI. The similar trend was found for high BP. However, we did not observe that same-sex parent-offspring correlations of BMI and BP were stronger than the correlations for mother-son or father-daughter.ConclusionsOur study suggested that familial environments, alongside the impact of genetic factors, could be important non-communicable chronic diseases (NCD) risk factors. Family-based intervention taking both mother and father into account might have great potential in NCD prevention for younger generation.

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“…Neste estudo observou-se que 18,6% dos escolares apresentavam elevações da pressão arterial, o que está em conformidade com alguns estudos nacionais recentes, os quais mostraram que a incidência dessa enfermidade pode variar bastante conforme a região estudada (12% a 44,7%), devido a diferenças metodológicas referentes aos métodos de amostragem, ao tamanho e características da amostra, à qualidade dos instrumentos de medida e à técnica empregada, e ainda ao número de aferições e pontos de corte para classificação da pressão arterial. Além disso, vale ressaltar que a incidência de HAS também sofre influência de variáveis intervenientes, dado o seu caráter multifatorial, que envolve tanto aspectos genéticos como ambientais (MAGALHÃES et al, 2002;FERMINO et al, 2009).…”

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Pressão arterial elevada, excesso de peso e obesidade abdominal em crianças e adolescentes

et al. 2011

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O objetivo deste estudo foi verificar a frequência de pressão arterial elevada em meninos e meninas de 10 a 16 anos de idade, analisando sua associação com o excesso de peso corporal e a obesidade abdominal. Foram avaliadas 764 crianças e adolescentes (365 meninos e 399 meninas) provenientes de cinco escolas da rede pública de Curitiba. Avaliaram-se a estatura, o peso corporal, a circunferência abdominal e as pressões arteriais sistólica e diastólica de repouso. Foram utilizados o teste t de Student e Qui-Quadrado. Para todas as análises considerou-se p<0,05. As frequências de pressão arterial elevada e de excesso de peso corporal nos escolares foram iguais a 18,6% e 30,8%, respectivamente. Em 33,1% dos alunos constatou-se obesidade abdominal. Neste estudo a prevalência de pressão arterial elevada constitui um fator a ser investigado. Palavras-chave: Pressão arterial. Escolares. Excesso de peso. Obesidade abdominal.

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Fatores genéticos na agregação familiar da pressão arterial de famílias nucleares portuguesas

Abstract: SummaryBackground: Despite of the increase in the prevalence of hypertension in Portugal, the importance of genetic factors in blood pressure (BP) has not been studied extensively in our country.

Cited by 8 publications

References 24 publications

The possible role of chromosome X variability in hypertensive familiarity

The possible role of chromosome X variability in hypertensive familiarity

Familial correlation and aggregation of body mass index and blood pressure in Chinese Han population

Pressão arterial elevada, excesso de peso e obesidade abdominal em crianças e adolescentes

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