Correlação entre o consumo de oxigênio obtido pelo método de Fick e pela calorimetria indireta no paciente grave

Marson, Fernando P.; Auxiliadora‐Martins, Maria; Coletto, Francisco Antônio; Campos, Antonìo; Basile-Filho, Aníbal

doi:10.1590/s0066-782x2004000100007

Cited by 10 publications

(2 citation statements)

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“…Also Fick’s principle has been applied in humans for many years to measure VO 2 by combining data of regional blood flow and arterial-venous oxygen content difference. However, both measurements can generate data with a high variability and, therefore, its use for clinical decision-making has been questioned [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Respirometry as Novel Technique to Monitor Mitochondrial Function: A Feasibility Study in Healthy Volunteers

2016

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BackgroundThe protoporphyrin IX-triplet state lifetime technique (PpIX-TSLT) is proposed as a potential clinical non-invasive tool to monitor mitochondrial function. This technique has been evaluated in several animal studies. Mitochondrial respirometry allows measurement in vivo of mitochondrial oxygen tension (mitoPO2) and mitochondrial oxygen consumption (mitoVO2) in skin. This study describes the first use of a clinical prototype in skin of humans.MethodsThe clinical prototype was tested in 30 healthy volunteers. A self-adhesive patch containing 2 mg 5-aminolevulinic acid (ALA) was applied on the skin of the anterior chest wall (sternal) for induction of mitochondrial protoporphyrin IX and was protected from light for 5 h. MitoPO2 was measured by means of oxygen-dependent delayed fluorescence of protoporphyrin IX. MitoVO2 was determined by dynamic mitoPO2 measurements on the primed skin, while locally blocking oxygen supply by applying local pressure with the measurement probe. MitoPO2 was recorded before and during a 60-s period of compression of the microcirculation, at an interval of 1 Hz. Oxygen consumption (i.e. the local oxygen disappearance rate) was calculated from the decay of the mitoPO2 slope.ResultsOxygen-dependent delayed fluorescence measurements were successfully performed in the skin of 27 volunteers. The average value (± SD) of mitoPO2 was 44 ± 17 mmHg and mean mitoVO2 values were 5.8 ± 2.3 and 6.1 ± 1.6 mmHg s-1 at a skin temperature of 34°C and 40°C, respectively. No major discomfort during measurement and no long-term dermatological abnormalities were reported in a survey performed 1 month after measurements.ConclusionThese results show that the clinical prototype allows measurement of mitochondrial oxygenation and oxygen consumption in humans. The development of this clinically applicable device offers opportunities for further evaluation of the technique in humans and the start of first clinical studies.

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Section: Introductionmentioning

confidence: 99%

Cutaneous Respirometry as Novel Technique to Monitor Mitochondrial Function: A Feasibility Study in Healthy Volunteers

2016

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“…Indirect calorimetry is a noninvasive method used for VO 2 measurement by means of an ergospirometer 5 . Difficulty of access to and high costs of ergospirometric evaluation, however, cause predictive methods to be more frequently used than ergospirometry in the assessment of functional capacity 6 .…”

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confidence: 99%

Equações para a previsão da potência aeróbia (VO2) de jovens adultos brasileiros

Magrani¹,

Pompeu²

2010

Arq. Bras. Cardiol.

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Mechanical ventilation mode (volume × pressure) does not change the variables obtained by indirect calorimetry in critically ill patients

Clapis

Auxiliadora‐Martins

Japúr

et al. 2010

Journal of Critical Care

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Correlação entre o consumo de oxigênio obtido pelo método de Fick e pela calorimetria indireta no paciente grave

Cited by 10 publications

References 15 publications

Cutaneous Respirometry as Novel Technique to Monitor Mitochondrial Function: A Feasibility Study in Healthy Volunteers

Cutaneous Respirometry as Novel Technique to Monitor Mitochondrial Function: A Feasibility Study in Healthy Volunteers

Equações para a previsão da potência aeróbia (VO2) de jovens adultos brasileiros

Mechanical ventilation mode (volume × pressure) does not change the variables obtained by indirect calorimetry in critically ill patients

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