Trends in male contraception

Pasqualotto, Fábio Firmbach; Lucon, Antônio Marmo; Pasqualotto, Eleonora Bedin; Arap, Sami

doi:10.1590/s0041-87812003000500007

Cited by 9 publications

(9 citation statements)

References 45 publications

(31 reference statements)

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“…Testosterone with GnRH antagonists has proven much more promising. Better results can be obtained if the dose of testosterone is low, and its administration delayed [17]. GnRH antagonists do not cause any side effects other than skin reactions due to histamine release.…”

Section: Gnrh Agonists and Antagonistsmentioning

confidence: 99%

“…GnRH antagonists do not cause any side effects other than skin reactions due to histamine release. Currently, efforts are under way to develop this method, but it will be difficult because of their high cost, difficulty of administration, low potency and local irritation [17].…”

Section: Gnrh Agonists and Antagonistsmentioning

confidence: 99%

“…Promising results were obtained using a combination of a progestin with testosterone esters in a delayed release formulation and administered by injection. According to present knowledge the optimal solution is subcutaneous implant of progestin and androgen [17].…”

Section: Connection Between Adverse Effects and Ways Of Administrationmentioning

confidence: 99%

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Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception

Zdrojewicz¹,

Konieczny²,

Papier³

et al. 2015

Adv Clin Exp Med

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Compared to efficient and secure female contraception, a vasectomy and condoms are the only options for men. The choice of male contraceptive methods is limited, so contraception mainly rests on the shoulders of women. Several concepts are considered: testosterone administration -inhibiting pituitary secretion of lutropin (LH) and follicle stimulating hormone (FSH), progestogen -affecting the secretion of gonadotropin and gonadoliberin (GnRH) antagonists. New potential targets for non-hormonal male contraception were discovered: glyceraldehyde-3-phosphate-dehydrogenase (GAPDHS) -specific to male germ cells and voltage-gated cation channel (CatSper). Both are responsible for sperm motility. Drugs such as thioridazine used in schizophrenia treatment and phenoxybenzamine (antihypertensive activity) exhibit a contraceptive effect. Similar action exhibits an analogue of lonidamine -adjudin and an antagonist of retinoic acid receptors (BMS-189453). Researchers are working on a contraceptive vaccine, whose active ingredient is epididymal protease inhibitor (Eppin). Another promising method acts by blocking Bromodomain testis-specific proteins (Brdt) involved in the process of spermatogenesis. JQ1-the Brdt inhibitor causes reversible infertility without affecting the endocrine signaling pathways. A recent discovery of Juno as the binding partner for Izumo1 identifies these proteins as the cell-surface receptor pair, essential for gamete recognition and this interaction can be inhibited by an anti-Juno monoclonal antibody. Our review shows that the situation of men can change and investigators are close to the optimal solution. In the near future men will be able to choose the best contraceptive suited to their needs (Adv Clin Exp Med 2015, 24, 4, 705-714).

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Section: Gnrh Agonists and Antagonistsmentioning

confidence: 99%

Section: Gnrh Agonists and Antagonistsmentioning

confidence: 99%

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Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception

Zdrojewicz¹,

Konieczny²,

Papier³

et al. 2015

Adv Clin Exp Med

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“…8,[36][37][38][39][40][41][42][43] The purpose of this review was to summarize the published data regarding hormone-based male contraceptive treatment options.…”

Section: Hormonal Treatmentmentioning

confidence: 99%

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Manetti

Honig

2010

Int J Impot Res

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Traditionally, male contraception has consisted of either barrier methods, such as condoms, or vasectomy. However, in recent years, we have made great strides in the basic science and clinical medicine to better understand the feedback mechanisms and physiology of the male reproductive system. These advances have enabled the development of several nonsurgical, hormonal, reversible, well-tolerated alternatives for male contraception. Men are more likely now than ever to participate in the choice of contraceptive techniques. This review will discuss the current status and recent developments in nonsurgical hormonal male contraception, a field that has been historically limited by social, financial and physiological challenges.

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“…The majority of the men in most of the countries are willing to use oral contraceptives if such method is available [3]. Recent surveys show that well over 50 % of men would use "the pill" if it were available [4]. In modern research, promising number of successful pharmacologically active compounds were discovered from the herbs known for its anti-microbial, anti-fungal properties, anti-inflammatory and anti-ageing properties [5].…”

mentioning

confidence: 99%