Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Manetti, G J; Honig, Stanton C.

doi:10.1038/ijir.2010.2

Cited by 30 publications

(32 citation statements)

References 107 publications

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“…According to Manetti and Honig [6] this is due to concerns around long-term effects and male health implications. However surely that would be very unfair considering that the female pill was introduced to the market less than ten years after its development, with refinement taking place alongside its use in practice during which side-effects and health problems became apparent.…”

Section: Testosterone-progestin Combinations Testosterone With Gnrh mentioning

confidence: 99%

“…Nonetheless, 50% of the 1,000,000 conceptions occurring daily have been reported to still be unplanned [5]. At times of governmental pleas for declining birth-rates around the globe, and observed changes in the traditional gender roles in family life, the development and introduction of a male contraception pill, which interestingly according to Manetti and Honig [6] predated the female pill through research on the effects of testosterone on the suppression of spermatogenesis in 1939, "…..is surely long overdue"; especially since "men enjoy the pleasures of sex, but can do little to contribute to the task of family planning" [5].…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, pharmaceutical research has continued to improve the substances necessary for this ideal male "pill". In a recent review, Manetti and Honig [6] presented the outcomes of these studies and listed the pros and cons of 16 male hormonal contraceptive options in four different clusters (testosterone,…”

Section: Introductionmentioning

confidence: 99%

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Attitudes towards the male contraceptive pill: psychosocial and cultural explanations for delaying a marketable product

Wersch

Eberhardt

Stringer

2012

Basic Clin. Androl.

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Even though years of research on the male contraceptive pill have been conducted, a marketable product is still absent from the arsenal of male and female products of contraception. In this paper the following psychosocial and cultural factors have been elicited from the literature in order to reveal explanations for this delay: acceptability, trust, fear of side-effects, perceptions of contraceptive responsibility and fear of losing connotations of masculinity. Regardless of cultural variation, overall there seems to be a positive attitude towards the acceptability of male contraceptive for both males and females, especially males in stable relationships. There has been some indication that the media have played an important role in distorting the results of research regarding male and female trust. Ongoing and future research into several projects on psychosocial and cultural factors is described.

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Section: Testosterone-progestin Combinations Testosterone With Gnrh mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Attitudes towards the male contraceptive pill: psychosocial and cultural explanations for delaying a marketable product

Wersch

Eberhardt

Stringer

2012

Basic Clin. Androl.

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“…Nous rappellerons à ce sujet les résultats -modestes, mais non négligeables -des équipes françaises intéressées. Dans ce cadre clinique, les résultats nous paraissent positifs et devraient logiquement se traduire par une commercialisation de telles méthodes [3,4]. L'un des objectifs de ce livre est de fournir des arguments favorisant la diffusion de ces « méthodes nouvelles ».…”

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La contraception pour les hommes, une cause perdue?

Spencer¹

2013

La Contraception Masculine

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La contraception masculine est pratiquée au quotidien par de très nombreux hommes au moyen principalement de deux procédés, le préservatif et le retrait. D'autres ont recours à la vasectomie, « contraception permanente ». Ces méthodes sont abordées dans plusieurs textes, sous différents aspects pratiques et théoriques.Toutefois, depuis cinquante ans [1, 2], des recherches sont menées pour mettre au point d'autres techniques de contraception masculine, appelées « méthodes nouvelles ». Cet ouvrage en présente les différentes modalités, à travers plusieurs textes rapportant les résultats des essais de contraception masculine qui utilisent des dérivés hormonaux ou l'élévation de la température testiculaire. Il s'agit de protocoles faisant appel à des volontaires, dont l'objectif est d'évaluer leur réelle efficacité contraceptive, leurs effets indésirables et leurs bénéfices éventuels. Nous rappellerons à ce sujet les résultats -modestes, mais non négligeables -des équipes françaises intéressées. Dans ce cadre clinique, les résultats nous paraissent positifs et devraient logiquement se traduire par une commercialisation de telles méthodes [3,4]. L'un des objectifs de ce livre est de fournir des arguments favorisant la diffusion de ces « méthodes nouvelles ». Pour autant, sont aussi envisagées quelques unes des possibilités futures de contraception masculine.Un ouvrage sur la contraception masculine doit forcément se confronter aux deux questions suivantes : les hommes veulent-ils assumer la responsabilité contraceptive? Les femmes veulent-elles la leur laisser ? En effet, comme le souligne B. Spencer p. 192 de cet ouvrage, « la disponibilité élargie d'un choix contraceptif suppose en amont un investissement scientifique et financier dans la recherche fondamentale, clinique et comportementale. Un tel investissement n'est valable que si le but visé est estimé réaliste, utile, pertinent et rentable. Si ces conditions ont été largement réunies au cours des dernières décennies pour la contraception féminine, il convient de se demander pourquoi il n'en a pas été de même pour les méthodes masculines ». De fait, les changements sociaux récents -modifications des structures familiales, émancipation des femmes, changements d'attitude des hommes envers la santé et le bien-être -ne sont-ils pas suffisants pour que le moment soit propice à l'introduction de nouvelles formes de contraception masculine ?

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“…Understanding the genetics and molecular basis of fertilization and the oocyte-to-embryo transition has important clinical implications, as approximately 15% of couples are infertile and genetic causes may play a prominent factor in these cases (2,3). Additionally, there is a need for novel contraceptive technologies, and understanding the genetics and molecular basis of fertilization will aid in the development of contraceptives (4). Finally, there is concern that the increased reliance on assisted reproductive technologies (ART) to treat clinical cases of infertility may result in future health issues for children conceived using these technologies (5,6).…”

Section: Introductionmentioning

confidence: 99%

Fertilization and the oocyte-to-embryo transition in C. elegans

Marcello¹,

Singson²

2010

BMB Reports

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Fertilization is a complex process comprised of numerous steps. During fertilization, two highly specialized and differentiated cells (sperm and egg) fuse and subsequently trigger the development of an embryo from a quiescent, arrested oocyte. Molecular interactions between the sperm and egg are necessary for regulating the developmental potential of an oocyte, and precise coordination and regulation of gene expression and protein function are critical for proper embryonic development. The nematode Caenorhabditis elegans has emerged as a valuable model system for identifying genes involved in fertilization and the oocyte-to-embryo transition as well as for understanding the molecular mechanisms that govern these processes. In this review, we will address current knowledge of the molecular underpinnings of gamete interactions during fertilization and the oocyte-to-embryo transition in C. elegans. We will also compare our knowledge of these processes in C. elegans to what is known about similar processes in mammalian, specifically mouse, model systems. [BMB reports 2010; 43(6): 389-399]

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Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Cited by 30 publications

References 107 publications

Attitudes towards the male contraceptive pill: psychosocial and cultural explanations for delaying a marketable product

Attitudes towards the male contraceptive pill: psychosocial and cultural explanations for delaying a marketable product

La contraception pour les hommes, une cause perdue?

Fertilization and the oocyte-to-embryo transition in C. elegans

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