Reversible Anti-Spermatogenic Effect of Piperine on Epididymis and Seminal Vesicles of Albino Rats

Chinta, Gopi Chand; Periyasamy, Latha

doi:10.1055/s-0042-108186

Cited by 12 publications

(20 citation statements)

References 32 publications

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“…Research findings also revealed that piperine could improve fertility through its positive effects on sperm count, viability and motility, weight of epididymis, caput, cauda, corpus, and seminal vesicles. However, some negative impacts, such as lowering of seminal fructose and an increase in malondialdehyde contents have also been observed by Chinta and Periyasamy (2016). Furthermore, piperine at a dose of 100 mg/kg decreased epididymis caput, cauda, and corpus weights (D'cruz & Mathur, 2005; Daware et al, 2000).…”

Section: Health Perspectivesmentioning

confidence: 81%

Piperine: A review of its biological effects

Haq

Imran

Nadeem

et al. 2020

Phytotherapy Research

176

106

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Medicinal plants have been used for years as a source of food, spices, and, in traditional medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family Piperaceae is one of the most widely used spices all over the world. It has a distinct sharp flavor attributed to the presence of the phytochemical, piperine. Apart from its use as a spice, P. nigrum is frequently used for medicinal, preservation, and perfumery purposes. Black pepper contains 2–7.4% of piperine, varying in content is associated with the pepper plant. Piperine displays numerous pharmacological effects such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, anti‐obesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects in various in vitro and in vivo experimental trials. Furthermore, piperine has also been documented for its hepatoprotective, anti‐allergic, anti‐inflammatory, and neuroprotective properties. This review highlights and discusses the medicinal and health‐promoting effects of piperine, along with possible mechanisms of its action in health promotion and disease prevention. In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several diseases.

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Section: Health Perspectivesmentioning

confidence: 81%

Piperine: A review of its biological effects

Haq

Imran

Nadeem

et al. 2020

Phytotherapy Research

176

106

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“…In our previous study, we have demonstrated the reversible spermatotoxic effect of piperine on male albino rats. [ 65 ] Piperine significantly impaired the testicular function of rats in the group ED and E4D through elevating the testicular cholesterol levels, resulting in the inhibition of the steroidogenesis after the treatment period. [ 66 ] A slight increase in the testicular cholesterol level was observed in the group E7D.…”

Section: Resultsmentioning

confidence: 99%

Reversible testicular toxicity of piperine on male albino rats

Chinta¹,

Coumar²,

Periyasamy³

2017

Phcog Mag

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Background:Piperine was widely used in traditional medicine for inducing sterility and abortion.Objective:To evaluate the effect of the piperine on testis of male albino ratsMaterials and Methods:Adult male rats were divided into four groups (n = 12). Group I (control): Rats were given vehicle p.o. i.e. 0.5% carboxymethyl cellulose in normal saline daily for 60 days, Group II (ED): Rats received piperine at a dose of 10 mg/kg body weight (b.w.) daily, Group III (E4D): Rats received piperine at a dose of 10 mg/kg b.w. on every 4th day, Group IV (E7D): Rats received piperine at a dose of 10 mg/kg b.w. on every 7th day. Half of the animals from each group were sacrificed after the treatment period (60 days), and the remaining were kept for drug-free withdrawal period (60 days) and then sacrificed.Results:Piperine significantly decreased the reproductive organ weights in groups ED and E4D. Piperine induced hormonal imbalance by altering the serum levels of follicle-stimulating hormone, luteinizing hormone, sex hormone binding globulin, serum, and testicular testosterone in groups ED and E4D. Furthermore, piperine decreased the activity of germ cell markers and Leydig cellular steroidogenic enzymes in the groups ED and E4D after 60 days. All the above-altered values returned to normal levels after withdrawal period. Histopathological findings also supported the above findings.Conclusion:From the above data, it can be concluded that piperine could be a good lead molecule for the development of reversible oral male contraceptive.SUMMARY Piperine was employed for the contraceptive purposes in traditional medicinePiperine significantly impaired the spermatogenesis by decreasing the testicular hormone synthesis in groups ED and E4DPiperine disrupted the testicular antioxidant system by promoting the ROS production and hydroxyl radical generation in rat testis in groups ED and E4DHistopathological evidence supported the disruption of spermatogenesis by piperineAll the effects of piperine after the treatment period (i.e. 60 days) were back to normal after the withdrawal period (i.e., after 120 days).

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“…In young adult male rats that orally received 10 mg piperine/kg bw/day (suspended in normal saline containing 0.5% carboxymethyl cellulose) for 60 days, Chinta and co-workers observed a statistically significantly ( p < 0.05) reduced epididymal sperm count, sperm motility and sperm viability compared to the control group (the latter receiving the vehicle only), accompanied by histopathological changes in the testes and epididymides; statistically significantly increased serum gonadotropins (FSH, LH), with a reduced intra-testicular testosterone concentration; and statistically significantly reduced activity of anti-oxidant enzymes or other enzymes in the testes and epididymides (for details, see Table 1 ) [ 16 , 62 ]. Data on reproductive organ weights were also recorded in this study, but in one of the two publications dealing with this study, inconsistencies were noticed between the testes weights and calculated indexes or a coefficient based on testes and body weights [ 62 ].…”

Section: Safety Aspectsmentioning

confidence: 99%

“…Primarily in in vitro and in animal studies, as well as in some human studies, piperine has been shown to be a biologically versatile compound that can interact with a variety of chemically and functionally diverse biomolecular targets, such as enzymes, membrane transporters, receptors or other biomolecules. For example, piperine may provide protection against forms of oxidative damage and improve the activities of compromised anti-oxidative defence mechanisms (e.g., related to superoxide dismutase or catalase), but depending on the study settings, may also decrease the anti-oxidative defence mechanisms and among others, piperine further displays the potential to influence the activity of drug-metabolizing enzymes, including enzymes involved in phase I (cytochrome P-450-enzymes) and phase II metabolism (e.g., UDP-glucuronosyltransferases), to interact with cellular drug transporters (e.g., P-glycoprotein) or to modulate the cellular targets (monoamine oxidase) associated with neurodegenerative diseases [ 1 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus

Ziegenhagen

Heimberg

Lampen

et al. 2021

Foods

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Piperine is a natural ingredient of Piper nigrum (black pepper) and some other Piper species. Compared to the use of pepper for food seasoning, piperine is used in food supplements in an isolated, concentrated form and ingested as a bolus. The present review focuses on the assessment of the possible critical health effects regarding the use of isolated piperine as a single ingredient in food supplements. In human and animal studies with single or short-term bolus application of isolated piperine, interactions with several drugs, in most cases resulting in increased drug bioavailability, were observed. Depending on the drug and extent of the interaction, such interactions may carry the risk of unintended deleteriously increased or adverse drug effects. Animal studies with higher daily piperine bolus doses than in human interaction studies provide indications of disturbance of spermatogenesis and of maternal reproductive and embryotoxic effects. Although the available human studies rarely reported effects that were regarded as being adverse, their suitability for detailed risk assessment is limited due to an insufficient focus on safety parameters apart from drug interactions, as well as due to the lack of investigation of the potentially adverse effects observed in animal studies and/or combined administration of piperine with other substances. Taken together, it appears advisable to consider the potential health risks related to intake of isolated piperine in bolus form, e.g., when using certain food supplements.

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Reversible Anti-Spermatogenic Effect of Piperine on Epididymis and Seminal Vesicles of Albino Rats

Abstract: From the results of this study, we can conclude that piperine has the potential to become a good lead for the reversible male oral contraceptive research.

Cited by 12 publications

References 32 publications

Piperine: A review of its biological effects

Piperine: A review of its biological effects

Reversible testicular toxicity of piperine on male albino rats

Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus

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