Piperine: A review of its biological effects

Abstract

Medicinal plants have been used for years as a source of food, spices, and, in traditional medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family Piperaceae is one of the most widely used spices all over the world. It has a distinct sharp flavor attributed to the presence of the phytochemical, piperine. Apart from its use as a spice, P. nigrum is frequently used for medicinal, preservation, and perfumery purposes. Black pepper contains 2–7.4% of piperine, varying in content is associated with the pepper plant. Piperine displays numerous pharmacological effects such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, anti‐obesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects in various in vitro and in vivo experimental trials. Furthermore, piperine has also been documented for its hepatoprotective, anti‐allergic, anti‐inflammatory, and neuroprotective properties. This review highlights and discusses the medicinal and health‐promoting effects of piperine, along with possible mechanisms of its action in health promotion and disease prevention. In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several diseases.

Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

“…Alkaloids inhibit dipeptidyl peptidase-4 (DDP-4), for example, bebeerine that degrades gut incretin hormones, including glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). A peptide that induces β-cell differentiation stimulates insulin biosynthesis and release, inhibits gastric emptying, directly reducing food intake and prevents glucagon release from the α-cells of the islets of Langerhans [ 20 , 47 , 48 ].…”

High-throughput wastewater analysis for substance use assessment in central New York during the COVID-19 pandemic

“…5). Piperine is a natural alkaloid in black pepper that possesses important therapeutic properties 96 and has been proposed as a potential inhibitor of SARS-CoV-2 RNAdependent RNA polymerase on the basis of molecular docking simulations. 97 Only two previous studies reported the occurrence of piperine in wastewater 98 or wastewater-impacted surface waters, 99 but neither of them quantied its actual concentration.…”

Multistage Extraction of Star Anise and Black Pepper Derivatives for Antibacterial, Antioxidant, and Anticancer Activity

“…The biological activities of black pepper are attributed to its piperine content, which is the extraction of alkaloid from black pepper. As the major constituent of pepper, piperine exhibited various pharmacological activities, e.g., antifungal (Phuna et al, 2020), antipyretic (Haq et al, 2021), anti-diarrhoeal (Goyal, 2017), analgesic (Chen et al, 2017), and anti-inflammatory activities (Li et al, 2016a;El-Ghazaly et al, 2020). However, the pharmaceutical activities and therapeutic properties of piperine are limited due to its poor water solubility.…”