Clinical and epidemiological features of AIDS/tuberculosis comorbidity

Song, Alice; Schout, Denise; Novaes, Hillegonda Maria Dutilh; Goldbaum, Moisés

doi:10.1590/s0041-87812003000400004

Cited by 14 publications

(7 citation statements)

References 10 publications

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“…An increased association with TB-AIDS co-infection was seen among AIDS patients living in the metropolitan area, and those with less education and lower baseline CD4 counts. These results are in agreement with other studies in Brazil [13– 16] and other areas [15,16]. …”

Section: Discussionsupporting

confidence: 94%

Tuberculosis and AIDS co-morbidity in Brazil: linkage of the tuberculosis and AIDS databases

Miranda¹,

Golub²,

Lucena³

et al. 2009

Braz J Infect Dis

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This study evaluated differences in AIDS patients with and without tuberculosis (TB) in Espírito Santo State, Brazil. Standard regional AIDS (SINAN, SISCEL, SICLOM and SIM) and tuberculosis (SINAN) databases were used. TB and AIDS databases were linked using Reclink software, version 3, with SPSS software support to identify co-infected cases. Data from July 2000 to June 2006 in Espírito Santo State were linked. The results showed 3,523 adult AIDS cases and 9,958 adult TB cases resulted in 430 co-infected patients, who were compared to 1,290 AIDS patients who never developed TB. Among 430 co-infected patients, TB was diagnosed first in 223 (51.9%), AIDS was first in 44 (10.2%), and AIDS and TB were diagnosed concurrently in 163 (37.9%). Median age did not differ between co-infected cases (36 years (interquartile range [IQR] 29–43) and non-co-infected cases (34 years; IQR 28–42). Pulmonary tuberculosis was diagnosed in 239 (55.6%); 109 (25.3%) had extra-pulmonary TB and 82 (19.1%) had both presentations. In the final logistic regression model, living in a metropolitan area [Odds Ratio (OR)=1.43 (95% Confidence Interval (CI) 1.05–1.95)], education ≤3 years [OR=3.03 (95%CI 1.56–5.88)] and CD4 counts ≤200/mm3 [OR=1.14 (95%CI 1.09–1.18)] were associated with co-infection. This report emphasizes the significance of tuberculosis among AIDS cases in Brazil, and highlights the importance of evaluating secondary data for purposes of improving data quality and developing public health interventions.

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Section: Discussionsupporting

confidence: 94%

Tuberculosis and AIDS co-morbidity in Brazil: linkage of the tuberculosis and AIDS databases

Miranda¹,

Golub²,

Lucena³

et al. 2009

Braz J Infect Dis

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“…Heterosexual is the commonest mode of transmission of HIV infection according to Song et al 17 The present study also depicted that heterosexual route was the most common route of transmission (91.33%) followed by blood transfusion (4.66%).…”

Section: Discussionsupporting

confidence: 75%

Syndemic Interaction Between Hiv and Tb- A Catastrophic Duet

Kour¹,

Kaur²,

D³

et al. 2018

jemds

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BACKGROUND TB is the most common opportunistic infection (OI) among HIV-infected individuals and co-infected individuals are at high risk of death. The risk of developing tuberculosis (TB) is estimated to be between 16-27 times greater in people living with HIV than among those without HIV infection. In 2015, there were an estimated 10.4 million cases of tuberculosis disease globally including 1.2 million (11%) among people living with HIV. Aims and Objectives-To study the distribution between demographic profile and HIV-TB co-infection and to study the clinical profile of patients with HIV-TB co-infection. MATERIALS AND METHODS A hospital-based observational study was conducted on 150 patients of HIV-TB co-infection coming to Department of Medicine/ ART Centre in Rajindra Hospital, Patiala. RESULTS A total of 150 patients were included in this study. Prevalence was more among unemployed and illiterate people. CONCLUSION This study showed that there were significant associations between various risk factors, demographic factors and HIV-TB coinfection.

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“…(16–18) It has been reported that TB/HIV co-infection is significantly associated with being in the 30–39 age bracket, with having a low level of education, with living in an urban area, and with having extrapulmonary TB. After the onset of AIDS, extrapulmonary forms of TB are known to have become more common in TB patients.…”

Section: Discussionmentioning

confidence: 99%

Perfil epidemiológico de pacientes adultos com tuberculose e AIDS no estado do Espírito Santo, Brasil: relacionamento dos bancos de dados de tuberculose e AIDS

et al. 2011

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Objective To evaluate the epidemiological profile of patients with tuberculosis (TB) only and that of patients with TB/AIDS in the state of Espírito Santo, Brazil, between 2000 and 2006. Methods For the patients of interest, we collected demographic and clinical data from the Epidemiological Surveillance Center (TB database), Brazilian Case Registry Database, and Brazilian National Mortality Database, as well as the Brazilian National CD4+/CD8+ T Lymphocyte Count and Viral Load Network Laboratory Test Control System and the Logistic Medication Monitoring System (HIV/AIDS databases). All of the compiled data were cross-referenced. Results During the study period, we identified 9,543 TB patients > 15 years of age, 437 of whom (4.6%) had AIDS. The median age did not differ between TB/AIDS and TB-only patients (35 years vs. 38 years). Of the 437 TB/AIDS patients, 298 (68.2%) were male, and 156 (35.8%) were in the 30–39 age bracket. In terms of TB treatment outcome, 79.0% were cured, 9.7% were referred to other facilities, 6.0% died, 5.2% abandoned treatment, and 0.2% developed multidrug-resistant TB. Death was 4.75 times more common in patients with TB/AIDS than in those with TB only. Pulmonary TB accounted for 82.4% of the cases. The combination of pulmonary and extrapulmonary TB was 8.2 times more common in the TB/AIDS patients than in the TB-only patients (95% CI: 6.2–10.8). Conclusions Our results emphasize the significance of AIDS among TB patients in Brazil, as well as the importance of evaluating secondary data in order to improve their quality and develop public health interventions.

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Clinical and epidemiological features of AIDS/tuberculosis comorbidity

Cited by 14 publications

References 10 publications

Tuberculosis and AIDS co-morbidity in Brazil: linkage of the tuberculosis and AIDS databases

Tuberculosis and AIDS co-morbidity in Brazil: linkage of the tuberculosis and AIDS databases

Syndemic Interaction Between Hiv and Tb- A Catastrophic Duet

Perfil epidemiológico de pacientes adultos com tuberculose e AIDS no estado do Espírito Santo, Brasil: relacionamento dos bancos de dados de tuberculose e AIDS

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