Fatores associados às formas evolutivas graves da infecção crônica pelo vírus da hepatite C

Vasconcelos, Romes Rufino de; Tengan, Fátima Mitiko; Cavalheiro, Norma de Paula; Ibrahim, Karim Yaqub; Pereira, Hayde; Barone, Antonio

doi:10.1590/s0037-86822006000500003

Cited by 6 publications

(4 citation statements)

References 23 publications

(10 reference statements)

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“…Patients infected at an older age or those with a longer disease course present with more advanced stages. 11 , 12 , 13 , 14 Several investigations have demonstrated rapid disease progression among patients infected at older ages, particularly in studies of patients enrolled with early-stage fibrosis (F0, F1), where progression to advanced fibrosis was more common among patients older than 40–50 years. 15 , 16 …”

Section: Discussionmentioning

confidence: 99%

Association between age at diagnosis and degree of liver injury in hepatitis C

Oliveira

Bortotti

Nunes

et al. 2014

The Brazilian Journal of Infectious Diseases

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Section: Discussionmentioning

confidence: 99%

Association between age at diagnosis and degree of liver injury in hepatitis C

Oliveira

Bortotti

Nunes

et al. 2014

The Brazilian Journal of Infectious Diseases

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“…The importance of the treatment of hepatitis C to avoid bad outcomes (death) has been clearly determined, as 55-85% of the individuals that acquire hepatitis C will remain infected by HCV after the acute phase 17 , with a 5-25% risk of developing cirrhosis in 25-30 years. Also, individuals with cirrhosis are at risk of developing liver discompensation (30% in 10 years) and HCC (1-3% per year) 21 , which are related to causes of death in the natural history of the disease. Data obtained herein were corroborated by scientific literature in the following aspect: treatment abandonment lead to death.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated With Mortality in Hepatitis C Patients

Sousa

Pessoa²,

Filho

et al. 2017

REV. CIÊNC. PLURAL

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Hepatitis C is the major cause for progressive liver disease, and afflicts approximately 158 million individuals globally1,2. It is estimated that between 2007 and 2009, the costs of treating chronic hepatitis C patients in Brazil have been over 90 million dollars, with antiviral drugs being responsible for 88% of total costs3.Transmission occurs mainly by contact with contaminated blood and hemoderivatives, with the use of intravenous drugs being the most common risk factor. Many patients acquire the Hepatitis C Virus (HCV) with no exposition to blood. Sexual transmission, considered an improbable route, can be related to sexual practices with mucous trauma and with individuals infected with HIV4. Therefore, the most elevated rates of hepatitis C are among individuals that use injectable drugs (45% of new cases), patients with liver failure undergoing hemodialisis (prevalence varies between 6 and 38%), and hemophiliacs (antiHCV rates of 44%)5.There still are no safe predictions on the evolution of a specific patient infected with HCV, once the differences in the evolution course of each patient depend not only on viral factors, but also depend on aspects related to the host and environment6,. However, it is known that hepatitis C evolves to the chronic form in 80% of acutely infected patients7, leading to cirrhosis, digestive hemorrhage, liver failure, liver cancer and death - representing the major cause of liver transplants along with alcoholism8.The factors associated with hepatitis C mortality are very important for the understanding of the natural history of this infection, as well as for the prediction of which patients will present more unfavorable prognosis and which will reach more severe stages of the disease. Therefore, the current study has the objective of establishing knowledge on the factors associated with death in hepatitis C patients, to guide the monitoring of the patient by the assisting physician.

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“…Cepas do vírus isoladas em diferentes regiões do mundo mostraram diferenças em 30,0% a 35,0% no seu genoma, o que permitiu classificá-las em seis genótipos maiores e mais de 100 subtipos (SY; JAMAL, 2006). Sabe-se que a evolução da hepatopatia e a resposta ao tratamento instituído estão vinculadas ao genótipo viral (VASCONCELOS et al, 2006).…”

Section: Introductionunclassified

Prevalência sorológica e intensidade da resposta humoral entre indivíduos infectados com Vírus da Hepatite C

Leitemperguer

Beck

2014

Semin. Cienc. Biol. Saude

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A infecção crônica pelo vírus da Hepatite C (HCV) é considerada grave, podendo progredir para cirrose e descompensação hepática. Objetivos: Verificar a prevalência da infecção pelo HCV entre os indivíduos triados, entre setembro de 2007 e setembro de 2009 determinando a correlação dos níveis séricos de anticorpos com presença do RNA viral. Métodos: Os resultados sorológicos da pesquisa de anticorpos anti HCV pelo método imunoenzimático ELISA (BioMérieux®) de 4536 indivíduos foram analisados retrospectivamente. O resultado da pesquisa molecular (COBAS AMPLICOR HCV Roche Diagnostics®) de 79 pacientes foi obtido através de registros médicos, sendo os genótipos 1 e 3 os mais frequentes. A probabilidade do resultado sorológico estar relacionado com a pesquisa molecular foi verificada através de curva ROC, construída para diferentes valores de Índex (DO amostra/DO ponto de corte do ELISA). Resultados: Das amostras para as quais foi realizado o teste molecular, 82,3% confirmaram presença de RNA HCV. Os Valores preditivos positivos (VPP) e Valores preditivos negativos (VPN) para presença de viremia, considerando valores de Índex 4,0 3,0 e 2,0 foram: para Índex 4,0 sensibilidade (S) de 62%, especificidade (E) 64%, VPP de 89%, VPN de 27%. Para Índex 3,0 S=93,0%; E=36,0%, VPP 87%, VPN 55%. Para Índex 2,0 S=100%, E=21%, VPP 85%; VPN 100%. Conclusão: Pode-se inferir que há grande probabilidade de pacientes com reação sorológica para pesquisa de anti-HCV reagente e Índex menor que 2,0, terem suprimido a infecção pelo HCV, e com Índex superior a 4,0 apresentarem viremia presente. ResumoChronic infection with hepatitis C virus (HCV) is a severe infection that may progress to cirrhosis and hepatic decompensation. Objectives: To determine the prevalence of HCV infection amongst screened individuals, between September 2007 and September 2009 to determine the relationships between serum antibody levels and the presence of viral RNA. Methods: Serological results of the research to anti HCV antibodies by enzyme-linked immunosorbent assay-ELISA (BioMérieux ®) of 4536 subjects were analyzed retrospectively. The results of molecular research (Cobas AMPLICOR HCV Roche Diagnostics ®) of 79 patients were extracted from medical records, and genotypes 1 and 3 were the most frequent. The probability of serologic results to be related to molecular analysis was verified by ROC curve constructed for different values of Index (OD sample / OD cutoff ELISA). Results: Of samples for which the molecular test was performed, 82.3% confirmed the presence of HCV RNA. Positive predictive values (PPV) and negative predictive values (NPV) for the presence of viremia, considering Index values of 4.0 3.0 and 2.0 were: for the Index 4.0 sensitivity (S) of 62%, specificity (Sp) 64%, PPV 89%, NPV of 27%. In the Index 3.0 S = 93.0%; E = 36.0%, PPV 87%, NPV 55%. In the Index 2.0% S=100, E=21%, PPV 85%; VPN 100%. Conclusion: It can be inferred that there is high probability of patients with serological reaction for screening anti-HCV reagent, presenting Index lower...

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Fatores associados às formas evolutivas graves da infecção crônica pelo vírus da hepatite C

Cited by 6 publications

References 23 publications

Association between age at diagnosis and degree of liver injury in hepatitis C

Association between age at diagnosis and degree of liver injury in hepatitis C

Factors Associated With Mortality in Hepatitis C Patients

Prevalência sorológica e intensidade da resposta humoral entre indivíduos infectados com Vírus da Hepatite C

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