Análise da biocompatibilidade de cones de biovidro e biovitrocerâmico (Biosilicato®) em cavidade eviscerada de coelho

Brandão, Simone Milani; Schellini, Silvana Artioli; Padovani, Carlos Roberto; Peitl, Oscar; Hashimoto, Emerson

doi:10.1590/s0034-72802013000100005

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Peitl et al [18] demonstrated a controlled crystallization of glasses of the same system increased their average bending strength from 75 MPa of the parent glass to 210 MPa. In vitro , in vivo, and clinical studies [14–16, 19–25] have shown the efficiency of Biosilicate® for regenerating bone tissue due to its features, such as high bioactivity, osteoconductivity, osteoinductivity, osteoconductivity, noncytotoxicity, nongenotoxicity, and antibacterial properties. Such excellent biological and special mechanical properties have made Biosilicate® promising bioceramic reinforcement for the production of scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Scaffolds of Poly(ε-caprolactone)/Biosilicate® Biocomposites Prepared by Generative Manufacturing Process

Cunha

Neto

Micocci

et al. 2019

International Journal of Biomaterials

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Scaffolds of poly(ε-caprolactone) (PCL) and their biocomposites with 0, 1, 3, and 5 wt.% Biosilicate® were fabricated by the generative manufacturing process coupled with a vertical miniscrew extrusion head to application for restoration of bone tissue. Their morphological characterization indicated the designed 0°/90° architecture range of pore sizes and their interconnectivity is feasible for tissue engineering applications. Mechanical compression tests revealed an up to 57% increase in the stiffness of the scaffold structures with the addition of 1 to 5 wt.% Biosilicate® to the biocomposite. No toxicity was detected in the scaffolds tested by in vitro cell viability with MC3T3-E1 preosteoblast cell line. The results highlighted the potential application of scaffolds fabricated with poly(ε-caprolactone)/Biosilicate® to tissue engineering.

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