1.10 Bioactive Glass-Ceramics ☆

Hoppe, Alexander; Boccardi, Elena; Ciraldo, Francesca E.; Boccaccini, A. R.; Hill, Rosalind

doi:10.1016/b978-0-12-803581-8.10238-3

Cited by 5 publications

(4 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism underlying osteoinductive materials such as bioceramics (calcium phosphate and bioglasses) is the release of Ca 2+ and PO 4 3− ions, leading to bone-like apatite formation, which can absorb osteogenic proteins on the graft surface. [39][40][41] Osteoconductivity of materials enables the formation of a bone-like apatite layer at the material surface, which can bond to surrounding bone tissue directly. [40] Osteoconductive capacity is an outstanding advantage of the majority of bioceramics such as calcium phosphate, HA, -TCP, and bioglasses.…”

Section: Materials Considerations For Biocompatibility Mechanical Strength and Osteogenesismentioning

confidence: 99%

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Xie

Liang

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

The failure to repair critical-sized bone defects often leads to incomplete regeneration or fracture non-union. Tissue-engineered grafts have been recognized as an alternative strategy for bone regeneration due to their potential to repair defects. To design a successful tissue-engineered graft requires the understanding of physicochemical optimization to mimic the composition and structure of native bone, as well as the biological strategies of mimicking the key biological elements during bone regeneration process. This review provides an overview of engineered graft-based strategies focusing on physicochemical properties of materials and graft structure optimization from macroscale to nanoscale to further boost bone regeneration, and it summarizes biological strategies which mainly focus on growth factors following bone regeneration pattern and stem cell-based strategies for more efficient repair. Finally, it discusses the current limitations of existing strategies upon bone repair and highlights a promising strategy for rapid bone regeneration.

show abstract

Section: Materials Considerations For Biocompatibility Mechanical Strength and Osteogenesismentioning

confidence: 99%

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Xie

Liang

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Two commonly used glass-ceramic coating material available for the benefit of improving mechanical strength such as apatite-wollastonite (A-W) containing glass-ceramic (BGC) [78], and modified early-stage surface reactivity such as 45S5 sintered bioactive glass [79]. The A-W glass-ceramic system was developed by Professor Tadashi Kokubo and his colleagues and has been proven to exhibit good mechanical, physical and biological properties when its crystallization behavior was extensively evaluated [80]. Bioactive glass-ceramics serve as adequate options for coating applications because of their ability to form hydroxyapatite layer.…”

Section: Bioactive Glass Coatingmentioning

confidence: 99%

Bioactive glass coatings on metallic implants for biomedical applications

Oliver

et al. 2019

Bioactive Materials

138

View full text Add to dashboard Cite

Metallic implant materials possess adequate mechanical properties such as strength, elastic modulus, and ductility for long term support and stability in vivo. Traditional metallic biomaterials, including stainless steels, cobalt-chromium alloys, and titanium and its alloys, have been the gold standards for load-bearing implant materials in hard tissue applications in the past decades. Biodegradable metals including iron, magnesium, and zinc have also emerged as novel biodegradable implant materials with different in vivo degradation rates. However, they do not possess good bioactivity and other biological functions. Bioactive glasses have been widely used as coating materials on the metallic implants to improve their integration with the host tissue and overall biological performances. The present review provides a detailed overview of the benefits and issues of metal alloys when used as biomedical implants and how they are improved by bioactive glass-based coatings for biomedical applications.

show abstract

“…Even though apatite mineralization mechanisms are only one indicator of the ability of bioceramics to interact with the physiological environment, they provide an insight into the release and degradation that will directly affect the biological performance of these materials. Although the biological responses to bioactive ions released from inorganic biomaterials have been widely studied, the underlying relationship between the bioactive behavior, ionic release, cell interaction, and the effect of extracellular matrix deposition as a result of cell maturation due to the biomineralization process, are not yet fully understood 12,41–45 …”

Section: Introductionmentioning

confidence: 99%

“…Although the biological responses to bioactive ions released from inorganic biomaterials have been widely studied, the underlying relationship between the bioactive behavior, ionic release, cell interaction, and the effect of extracellular matrix deposition as a result of cell maturation due to the biomineralization process, are not yet fully understood. 12,[41][42][43][44][45] The in vitro study of cell and tissue biomineralization is important to understand the effect of biomaterials on bone regeneration processes, considering that mineralization of the extracellular matrix is essential in the bone formation process. 43,[46][47][48][49][50][51] The MC3T3-E1 cell line is one of the most implemented in vitro models to monitor the differentiation processes from pre-osteoblasts to osteoblasts in contact with a biomaterial.…”

mentioning

confidence: 99%

Mineral matrix deposition of MC3T3‐E1 pre‐osteoblastic cells exposed to silicocarnotite and nagelschmidtite bioceramics: In vitro comparison to hydroxyapatite

Rincón‐López,

Hermann‐Muñoz,

Detsch

et al. 2024

J Biomedical Materials Res

View full text Add to dashboard Cite

This work presents the effect of the silicocarnotite (SC) and nagelschmidtite (Nagel) phases on in vitro osteogenesis. The known hydroxyapatite of biological origin (BHAp) was used as a standard of osteoconductive characteristics. The evaluation was carried out in conventional and osteogenic media for comparative purposes to assess the osteogenic ability of the bioceramics. First, the effect of the material on cell viability at 24 h, 7 and 14 days of incubation was evaluated. In addition, cell morphology and attachment on dense bioceramic surfaces were observed by fluorescence microscopy. Specifically, alkaline phosphatase (ALP) activity was evaluated as an osteogenic marker of the early stages of bone cell differentiation. Mineralized extracellular matrix was observed by calcium phosphate deposits and extracellular vesicle formation. Furthermore, cell phenotype determination was confirmed by scanning electron microscope. The results provided relevant information on the cell attachment, proliferation, and osteogenic differentiation processes after 7 and 14 days of incubation. Finally, it was demonstrated that SC and Nagel phases promote cell proliferation and differentiation, while the Nagel phase exhibited a superior osteoconductive behavior and could promote MC3T3‐E1 cell differentiation to a higher extent than SC and BHAp, which was reflected in a higher number of deposits in a shorter period for both conventional and osteogenic media.

show abstract

1.10 Bioactive Glass-Ceramics ☆

Cited by 5 publications

References 58 publications

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Bioactive glass coatings on metallic implants for biomedical applications

Mineral matrix deposition of MC3T3‐E1 pre‐osteoblastic cells exposed to silicocarnotite and nagelschmidtite bioceramics: In vitro comparison to hydroxyapatite

Contact Info

Product

Resources

About