Ceramics for oculo-orbital surgery

Baino, Francesco; Brovarone, Chiara Vitale

doi:10.1016/j.ceramint.2014.12.086

Cited by 12 publications

(4 citation statements)

References 155 publications

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“…Although being mainly employed for the repair of bone defects, HA has also been recently proposed in some emerging applications in contact with soft tissues, including ophthalmology, wound regeneration and anticancer therapies; a comprehensive picture of these novel research topics has been recently provided by Kargozar et al [85]. As regards ocular applications, HA is marketed and clinically used since the 1980s in the form of porous orbital implants for enucleation (e.g., coralline or synthetic HA spheres) [86].…”

Section: Applications Of Ha In Tissue Engineeringmentioning

confidence: 99%

Hydroxyapatite for Biomedical Applications: A Short Overview

et al. 2021

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Calcium phosphates (CaPs) are biocompatible and biodegradable materials showing a great promise in bone regeneration as good alternative to the use of auto- and allografts to guide and support tissue regeneration in critically-sized bone defects. This can be certainly attributed to their similarity to the mineral phase of natural bone. Among CaPs, hydroxyapatite (HA) deserves a special attention as it, actually is the main inorganic component of bone tissue. This review offers a comprehensive overview of past and current trends in the use of HA as grafting material, with a focus on manufacturing strategies and their effect on the mechanical properties of the final products. Recent advances in materials processing allowed the production of HA-based grafts in different forms, thus meeting the requirements for a range of clinical applications and achieving enthusiastic results both in vitro and in vivo. Furthermore, the growing interest in the optimization of three-dimensional (3D) porous grafts, mimicking the trabecular architecture of human bone, has opened up new challenges in the development of bone-like scaffolds showing suitable mechanical performances for potential use in load bearing anatomical sites.

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Section: Applications Of Ha In Tissue Engineeringmentioning

confidence: 99%

Hydroxyapatite for Biomedical Applications: A Short Overview

et al. 2021

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“…Besides calcium phosphates, alumina is another well-known example of crystalline ceramic that has been widely used for decades to fabricate components of hip and knee joint prostheses (femur head, acetabular cup, and tibial plate) primarily due to its high-strength suitable for load-bearing applications, excellent wear resistance, and bioinertness (associated with maintenance of the desired physico-chemical and mechanical properties over time) (Rahaman et al, 2007 ). Porous alumina is clinically used only in the fabrication of orbital implants (spherical porous scaffolds) for enucleation that should allow fibrovascular ingrowth through the pore network and remain in the patient’s anophthalmic socket indefinitely without undergoing degradation (Baino et al, 2014 ; Baino and Vitale-Brovarone, 2015a ).…”

Section: Bioceramics: a Short Overviewmentioning

confidence: 99%

Bioceramics and Scaffolds: A Winning Combination for Tissue Engineering

Baino

Novajra

Vitale-Brovarone

2015

Front. Bioeng. Biotechnol.

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In the last few decades, we have assisted to a general increase of elder population worldwide associated with age-related pathologies. Therefore, there is the need for new biomaterials that can substitute damaged tissues, stimulate the body’s own regenerative mechanisms, and promote tissue healing. Porous templates referred to as “scaffolds” are thought to be required for three-dimensional tissue growth. Bioceramics, a special set of fully, partially, or non-crystalline ceramics (e.g., calcium phosphates, bioactive glasses, and glass–ceramics) that are designed for the repair and reconstruction of diseased parts of the body, have high potential as scaffold materials. Traditionally, bioceramics have been used to fill and restore bone and dental defects (repair of hard tissues). More recently, this category of biomaterials has also revealed promising applications in the field of soft-tissue engineering. Starting with an overview of the fundamental requirements for tissue engineering scaffolds, this article provides a detailed picture on recent developments of porous bioceramics and composites, including a summary of common fabrication technologies and a critical analysis of structure–property and structure–function relationships. Areas of future research are highlighted at the end of this review, with special attention to the development of multifunctional scaffolds exploiting therapeutic ion/drug release and emerging applications beyond hard tissue repair.

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“…It is due to several unique properties such as relatively low mass [1,2], low fractional density [3], low thermal conductivity [4], resistance to chemical attack [5], high specific surface area [6][7][8], high permeability and resistance to high temperature and thermal cycling [9][10][11][12]. For these reasons several materials are usually utilized for filters and membranes, as well as fuel cell electrodes, catalyst supports for biomaterials, piezoelectric materials, acoustically and thermally insulating bulk media [13][14][15].…”

Section: Introductionmentioning

confidence: 99%