Leishmaniose visceral: aspectos clínicos e laboratoriais

INTRODUCTION: This study sought to describe the profile and geographic distribution of reported cases of visceral leishmaniasis (VL) in the City of Campo Grande, State of Mato Grosso do Sul (MS), Brazil, from 2002 to 2009. METHODS: Human data were collected from the Brazilian National Information System for Notifiable Diseases. Canine cases and entomological data were obtained from the Information Service for Canine Visceral Leishmaniasis Control/Campo Grande, MS. RESULTS: A total of 951 records from 2002 to 2009 were investigated. The number of reported cases of VL in males was significantly higher (p < 0.0001) than that in females. The higher frequency observed among males was associated with age (p < 0.0001), which increased in individuals aged 40 years and older. The overall fatality rate was 7.4%. Entomological surveys conducted in 2006, 2007, and 2009 showed the insect vector Lutzomyia longipalpis to be present in all urban regions of the county. CONCLUSIONS: VL cases in humans and dogs, as well as in vectors, occurs in all urban regions of Campo Grande. Despite not observing tendencies of increase or reduction in the incidence of the disease due to aging, the major incidence in men is higher in those aged 40 years or above.

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“…The symptoms exhibited by patients in the present investigation have also been reported in other studies conducted in Brazil 21,[28][29][30] .…”

Section: Ethical Considerationssupporting

confidence: 88%

Profile and geographic distribution of reported cases of visceral leishmaniasis in Campo Grande, State of Mato Grosso do Sul, Brazil, from 2002 to 2009

Brazuna

Silva

Brazuna³

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…3,5,12 In this series, children of both sexes were equally affected. We would point out that the issue of higher rates of prevalence among males has not yet been completely understood.…”

Section: Discussionmentioning

confidence: 58%

Leishmaniose visceral: características clínico-epidemiológicas em crianças de área endêmica

Queiroz¹,

Alves²,

Correia³

2004

J. Pediatr. (Rio J.)

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Objective: To describe the clinical and epidemiological features of children with visceral leishmaniasis admitted to a pediatric referral hospital, and to describe treatment measures and the case fatality rate.Methods: Retrospective analysis of biological, demographic, clinical and laboratory data from children with visceral leishmaniasis admitted to Instituto Materno Infantil de Pernambuco (Recife, state of Pernambuco, northeastern Brazil) between 1996 and 2001.Results: 431 children were included in the study. Age ranged from 4 months to 13.7 years. 50.3% were female and 82.5% came from the interior of the state of Pernambuco. 70% of the patients lived in brick homes, and 70% were not served with piped water and sewage services. Average maternal schooling was 3 years. Clinical presentation included splenomegaly (97%), fever (95.6%) and malnourishment (44.5%). Associated infections were diagnosed in 10.9% of cases. The mean values for laboratory variables were: hemoglobin 6 g/dl, leukocyte count 3,516/mm³, and platelet count 118,641/ mm³. The first line treatment used in 98% of the cases was glucantime. Amphotericin B was used in seven cases. The case fatality rate was 10.2%. The main immediate causes of death were associated infections, bleeding and liver failure.Conclusions: Health care workers should be trained for the early recognition and appropriate management of visceral leishmaniasis and its complications.J Pediatr (Rio J). 2004;80(2):141-6: Visceral leishmaniasis, kala-azar, childhood, diagnosis, treatment, case fatality rate.

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“…In young adults (20-29 years) it was observed a high mortality rate (20%), similar to reports from other states' capitals such as Belo Horizonte (8-17%), São Luís (6.7%), Natal (9.0%) And Brasília (9.2%) 34. In the latest years, VL mortality rate in Brazil has increased gradually, from 3.2% in 1994 to 6.9% in 2005, representing an increase of 117% 29,8. Among the main factors that contribute to increase the mortality rate are late diagnosis and the epidemic expansion affecting groups of individuals with co-morbidities. Infectious complications and bleeding are the major risk factors for death in VL 26,27,28,29,24 . In the studied period, only 32.3% (62) of autochthonous cases of human VL had HIV serology, with a positivity of 6.9% (4).…”

Section: Resultsmentioning

confidence: 99%

Série temporal da leishmaniose visceral em Aracaju, estado de Sergipe, Brasil (1999 a 2008): aspectos humanos e caninos

Góes

Melo

Jeraldo

2012

Rev. bras. epidemiol.

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INTRODUÇÃO: Considerada doença negligenciada pela OMS, a Leishmaniose visceral (LV) tem se expandido e urbanizado, sendo sua transmissão e expansão associadas a diversos fatores. OBJETIVO: Avaliar aspectos epidemiológicos da LV no município de Aracaju/SE, por meio de estudo retrospectivo da série histórica de LV humana e canina no período de 1999-2008. MÉTODOS: Foram utilizados dados secundários do SINAN para os casos humanos, e o resultado dos inquéritos caninos e atendimentos da demanda passiva do Centro de Controle de Zoonoses (CCZ). RESULTADOS: Foram notificados 192 casos autóctones de LV humana, sendo 63,5% do gênero masculino. Crianças entre 1 e 4 anos foram mais acometidas (29,2%), seguidas de adultos entre 20-29 anos (15,6%) e de crianças entre 5-9 anos (15,1%). A letalidade geral foi de 8,9%, sendo mais acentuada em pessoas entre 60 a 69 anos (60%); 32,3% dos casos autóctones realizaram sorologia para HIV, com positividade de 6,9%. A confirmação laboratorial foi realizada principalmente mediante a imunofluorescência indireta isolada (71,1%). Dos 58.161 cães que realizaram sorologia a positividade foi de 5,4%, sendo 87,0% dos inquéritos realizados anualmente pelo CCZ, com uma positividade de 4,4%. Dos 7.501 cães trazidos ao CCZ por diversas queixas, o exame sorológico foi reagente em 12,0%. CONCLUSÃO: Os dados denotam o caráter endêmico da LV no município, mostrando a necessidade de ações que permitam a diminuição do risco para a população, principalmente aquela onde a incidência e a letalidade são maiores, como melhorias no diagnóstico da LV, assim como na co-infecção com HIV e no monitoramento da população canina, entre outros.

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Leishmaniose visceral: aspectos clínicos e laboratoriais

Abstract: In order to obtain accurate diagnosis and treatment, especially regarding health services of areas with low-incidence of visceral leishmaniasis, the diagnosis of patients with fever and visceromegaly, who come from endemic areas, should include visceral leishmaniasis.

Cited by 49 publications

References 19 publications

Profile and geographic distribution of reported cases of visceral leishmaniasis in Campo Grande, State of Mato Grosso do Sul, Brazil, from 2002 to 2009

Profile and geographic distribution of reported cases of visceral leishmaniasis in Campo Grande, State of Mato Grosso do Sul, Brazil, from 2002 to 2009

Leishmaniose visceral: características clínico-epidemiológicas em crianças de área endêmica

Série temporal da leishmaniose visceral em Aracaju, estado de Sergipe, Brasil (1999 a 2008): aspectos humanos e caninos

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