Enantiomers of sulfoxide of albendazole: cerebrospinal fluid and plasma levels and therapeutic efficacy in the treatment of patients with neurocysticercosis

Odashima, Newton Satoru

doi:10.1590/s0004-282x2003000200033

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Failure Of Anticysticercal Therapy: Possible Explanations1

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“…In addition, there are no data in the literature over which ALB metabolite (+)-ASOX, (−)-ASOX or both, is actually effective or the respective concentrations required for proper treatment of NCC. In a preliminary study, the (+)-ASOX enantiomer appeared to be the main metabolite against parenchymal brain cysticercosis [65]. Future studies concerning CSF enantiomer concentration and the clinical outcome of NCC would clarify the question over the therapeutic role of each ALB metabolite against the cysticerci.…”

Section: Failure Of Anticysticercal Therapy: Possible Explanationsmentioning

confidence: 92%