Ocular Toxocariasis: Clinical Features and Long-term Visual Outcomes in Adult Patients

Despreaux, Raphaelle; Fardeau, Christine; Touhami, Sara; Brasnu, Emmanuelle; Champion, Emmanuelle; Paris, Luc; Bodaghi, Bahram; LeHoang, Phuc

doi:10.1016/j.ajo.2016.03.050

Cited by 35 publications

(12 citation statements)

References 25 publications

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“…In addition, other studies used aqueous humor as samples and western blot to confirm diagnosis of OT, which is more specific than ELISA with serum antibodies. [ 31 ] We detected IgG antibodies to Toxocara using only an indirect ELISA based on the Toxocara larva antigen from blood samples. [ 16 , 17 ] Analyses using additional samples or methods could have confirmed our results.…”

Section: Discussionmentioning

confidence: 99%

Prognosis for ocular toxocariasis according to granuloma location

et al. 2018

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PurposeTo determine the prognosis for ocular toxocariasis (OT) according to the location of the granuloma and to identify factors associated with its recurrence within 1 year.MethodsOT patients were classified according to the granuloma lesion. After grouping the patients as posterior or peripheral, we compared sex, age, intraocular pressure, best corrected visual acuity (BCVA), degree of inflammation, immunoglobulin E, eosinophil profiles, recurrence, and complications in each group. We also identified factors associated with recurrence within 1 year.ResultsA total of 29 (61.70%) patients had granuloma at the periphery, and 18 (38.30%) patients had granuloma around the posterior pole. There were no significant differences in ocular or systemic evaluations except the initial BCVA. The mean decimal BCVA of the posterior pole granuloma group was worse than that of the peripheral granuloma group (p = 0.042). After treatment, the mean BCVA of the posterior pole granuloma group improved significantly (p = 0.019), and the final mean BCVA was not significantly different between the groups (p = 0.673). Multiple logistic regression analyses revealed that recurrence within a year was associated with age at diagnosis (p = 0.007).ConclusionsThe initial BCVA of OT patients differed according to the location of the granuloma, but the BCVA after treatment was not significantly different between the groups. Younger age was associated with recurrence within 1 year.

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Section: Discussionmentioning

confidence: 99%

Prognosis for ocular toxocariasis according to granuloma location

et al. 2018

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“…Here, we evaluated an Anti-Toxocara-IgG ELISA (Proto-ELISA) based on a mixture of larval somatic-and recombinant larval TES-antigen as well as an Anti-Toxocara-IgG WB (Proto-WB) based on larval somatic antigen, which have recently been brought to market. These assays were compared to an in-house ELISA (IH-ELISA) which has been in use for diagnostic purposes at the Institute of Specific Prophylaxis and Tropical Medicine of the Medical University Vienna, Austria, for more than two decades (Schneider et al, 2015) as well as to an established commercial WB (Com-WB) (Logar et al, 2004;Nicoletti et al, 2008;Qualizza et al, 2011;Zibaei et al, 2013;Artinyan et al, 2014;Despreaux et al, 2016;Lötsch et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

A new ELISA and western blot technique based on recombinant TES antigen and/or larval antigen for the detection of toxocariasis in humans

et al. 2020

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“…There was history of close and frequent contact with a dog (vector). Even in adult patients, severe vision loss is not an uncommon outcome of ocular toxocariasis [18], and standardized treatment protocols are yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

Unilateral Optic Neuritis in Children: Experience of a Tertiary Centre

Armindo

Pinto²,

Pereira³

et al. 2020

Eur Neurol

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Introduction: Optic neuritis (ON) is an inflammation of the optic nerve that can be associated with a multitude of different systemic conditions and primary CNS disorders. In children, only around 25% of unilateral ON cases are considered idiopathic. Despite being considered a clinical diagnosis per se, neuroimaging plays a crucial role in the diagnostic pathway for these patients. Methods: Demographic, clinical, and imaging data of all patients presenting with unilateral ON at a tertiary paediatric centre over 40 months (January 1, 2016, to April 30, 2019) were retrospectively analyzed. Results: A total of 10 patients filled the inclusion criteria. The average age of presentation was 14.1 years. Patients in this series had ON associated with multiple sclerosis (n = 2), anti-MOG demyelinating disorders (n = 2), and neuromyelitis optica with anti-AQP4 antibodies (n = 1). ON was determined to be secondary to Toxocara canis infection in 1 case and a side effect of anti-TNFα therapy (adalimumab) in another. MR imaging showed T2 hyperintensity and/or gadolinium enhancement of one of the optic nerves in all but 3 patients, and coincidently these were the cases with monophasic idiopathic ON (average follow-up period of 2 years). Additional brain MR findings directly contributed to the final diagnosis in half of the cases. Conclusions: These cases are demonstrative of the wide range of possible causes of unilateral ON in the paediatric population. The absence of typical ON features in MR imaging was strongly suggestive of idiopathic ON in this cohort (p < 0.01).

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Ocular Toxocariasis: Clinical Features and Long-term Visual Outcomes in Adult Patients

Cited by 35 publications

References 25 publications

Prognosis for ocular toxocariasis according to granuloma location

Prognosis for ocular toxocariasis according to granuloma location

A new ELISA and western blot technique based on recombinant TES antigen and/or larval antigen for the detection of toxocariasis in humans

Unilateral Optic Neuritis in Children: Experience of a Tertiary Centre

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