Prognosis for ocular toxocariasis according to granuloma location

Abstract

PurposeTo determine the prognosis for ocular toxocariasis (OT) according to the location of the granuloma and to identify factors associated with its recurrence within 1 year.MethodsOT patients were classified according to the granuloma lesion. After grouping the patients as posterior or peripheral, we compared sex, age, intraocular pressure, best corrected visual acuity (BCVA), degree of inflammation, immunoglobulin E, eosinophil profiles, recurrence, and complications in each group. We also identified factors associated with recurrence within 1 year.ResultsA total of 29 (61.70%) patients had granuloma at the periphery, and 18 (38.30%) patients had granuloma around the posterior pole. There were no significant differences in ocular or systemic evaluations except the initial BCVA. The mean decimal BCVA of the posterior pole granuloma group was worse than that of the peripheral granuloma group (p = 0.042). After treatment, the mean BCVA of the posterior pole granuloma group improved significantly (p = 0.019), and the final mean BCVA was not significantly different between the groups (p = 0.673). Multiple logistic regression analyses revealed that recurrence within a year was associated with age at diagnosis (p = 0.007).ConclusionsThe initial BCVA of OT patients differed according to the location of the granuloma, but the BCVA after treatment was not significantly different between the groups. Younger age was associated with recurrence within 1 year.

Toxocariasis ocular simulando un hamartoma retiniano. Reportefide un caso

“…Además, un dato que orientó el diagnóstico fue el antecedente de contacto con cachorros, que son uno de los huéspedes definitivos debido al proceso de defecación de huevos del parásito. Los anticuerpos para Toxocara pueden ser auxiliares al diagnóstico; por el método de ensayo de inmunoabsorción ligado a enzimas (ELISA), los anticuerpos tienen una especificidad del 92% y una sensibilidad del 78% 1,3 . Los títulos de anticuerpos se consideran positivos incluso con valores > 1:8 1,3 .…”

“…Los anticuerpos para Toxocara pueden ser auxiliares al diagnóstico; por el método de ensayo de inmunoabsorción ligado a enzimas (ELISA), los anticuerpos tienen una especificidad del 92% y una sensibilidad del 78% 1,3 . Los títulos de anticuerpos se consideran positivos incluso con valores > 1:8 1,3 . Es importante señalar que la positividad de los anticuerpos no permite confirmar la relación causal con los hallazgos oculares, ya que la seroprevalencia puede ser elevada incluso en pacientes sin manifestaciones de la enfermedad 4 .…”

Ocular toxocariasis simulating a retinal hamartoma. A case report

“…In addition, a data that guided the diagnosis was the history of contact with puppies, which are one of the definitive hosts due to the process of defecation of the parasite's eggs. Antibodies to Toxocara can be an aid to diagnosis; using the enzyme-linked immunosorbent assay (ELISA) method, the antibodies have a specificity of 92% and a sensitivity of 78% 1,3 . Antibody titers are considered positive even with values >1:8 1.3 .…”

Toxocarosis as a possible cause of gastrointestinal diseases in children

“…Они проникают через слизистую оболочку кишки в кровоток и кровью заносятся в разные органы: печень, легкие, поджелудочную железу, глаза, мозг и т.д. [10][11][12][13][14][15][16]. В пораженных органах развиваются специфические гранулемы с явлениями хронического воспаления, геморрагий и некрозов [11,17].…”