Encoding process in delayed recall impairment and rate of forgetting in Alzheimer's disease

Degenszajn, Jairo; Caramelli, Paulo; Caixeta, Leonardo; Nitrini, Ricardo

doi:10.1590/s0004-282x2001000200003

Cited by 14 publications

(8 citation statements)

References 19 publications

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“…There has been some debate whether increased forgetting rates in AD and aMCI may be a function of impaired learning with intact consolidation (Mayes, 1986), resulting in normal rates of forgetting once information is learned (Becker, Boller, Saxton, & McGonigle-Gibson, 1987; Christensen, Kopelman, Stanhope, Lorentz, & Owen, 1998; Degenszajn, Caramelli, Caixeta, & Nitrini, 2001; Freed, Corkin, & Cohen, 1987; Kopelman, 1985). Alternatively, as we hypothesize individuals with aMCI or AD have an increased rate of forgetting (Budson et al, 2007; Christensen et al, 1998; Greenaway et al, 2006; Kramer et al, 2004; Larrabee, Youngjohn, Sudilovsky, & Crook, 1993; Manes, Serrano, Calcagno, Cardozo, & Hodges, 2008; McBride et al, 2002; Reed, Paller, & Mungas, 1998), even when initial encoding is controlled for (Christensen et al, 1998; Hart, Kwentus, Harkins, & Taylor, 1988; Larrabee et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Memory consolidation in aging and MCI after 1 week.

et al. 2014

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Objective To assess consolidation in amnestic mild cognitive (aMCI) impairment, controlling for differences in initial learning and using a protracted delay period for recall. Methods Fifteen individuals with MCI were compared to fifteen healthy older adult controls on a story learning task. Subjects were trained to criteria to equalize initial learning across subjects. Recall was tested at both the 30-minute typically used delay and a 1-week delay used to target consolidation. Results Using repeated measures ANOVAs adjusted for age, we found group × time point interactions across the entire task between the final trial and 30-minute delay, and again between the 30-minute and 1-week delay periods, with MCI having greater declines in recall as compared to controls. Significant group main effects were also found, with MCI recalling less than controls. Conclusion Consolidation was impaired in aMCI as compared to controls. Our findings indicate that MCI-related performance typically measured at 30 minutes underestimates MCI-associated memory deficits. This is the first study to isolate consolidation by controlling for initial learning differences and using a protracted delay period to target consolidation in an MCI sample.

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Section: Introductionmentioning

confidence: 99%

Memory consolidation in aging and MCI after 1 week.

et al. 2014

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“…In contrast, AD patients do not seem to benefit from deeper encoding (i.e. semantic processing) and exhibit a flat pattern of recognition across all conditions (Corkin, 1982;see also, Grober, Ocepek-Welikson, & Teresi, 2009;Degenszajn, Caramelli, Caixeta, & Nitrini, 2001;Tounsi et al, 1999). Furthermore, semantic cueing is not as useful in patients as in healthy older adults.…”

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confidence: 99%

Alzheimer’s disease and memory strength: Gradual decline of memory traces as a function of their strength

Vallet

Rouleau

Benoit

et al. 2016

Journal of Clinical and Experimental Neuropsychology

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“…The reaction time on STADP showed a significant correlation (r=0.28; p=0.006) with Neuropsi Figure reaction time and an inverse correlation with proverb recognition (r= -0.26; p=0.01). The STADP memories also interfered in reaction time: episodic memory (r= -0.36; p=0.000), short-term memory (r= -0.34; p=0.01) as well as in proverb recognition, requested after a mean of forty minutes: episodic memory (r=0.37; p=0.000) and shortterm memory (r=0.28; p=0.007), pointing to better performance from those who better codified the information 30 . The same occurred with the total score on STADP (r=0.32; p=0.002).…”

Section: Mmse-total Maximum=30mentioning

confidence: 99%

Validity and reliability of the screening test for Alzheimer's disease with proverbs (STADP) for the elderly

Santos

Sougey

Alchieri

2009

Arq. Neuro-Psiquiatr.

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-The prevalence Alzheimer's disease with age compromises memory, language, executive functions, constructive praxis and abstraction, requiring early evaluation with standardized tests. Objective: To validate the Screening Test for Alzheimer's Disease with Proverbs (STADP), elaborated using pieces from the proverb memory game. Method: The test contains three stages (A: short-term memory, B: executive functions and language and C: episodic memory). The sample consisted of 91 elderly individuals with minimum age of 60 years and one year of schooling, CDR of one or zero, cared for at specialized services of UFPE, HGA and private institutions. Sociodemographic data, habits and health perception were assessed. Among the tests used were MMSE (convergent validity) and GDS (discriminating). Results: A good correlation with standardized test was found, acceptable internal consistency (0.71), cutoff point for schooling of 6.49 (low) (80% and 77.8%) and 8.66 (high) (84.6% and 86.1%); Kappa coefficient of 1 (p=0.000) inter-rater consistency. Conclusion: STADP is a valid test for screening Alzheimer's disease.KEy woRDS: Alzheimer's disease, proverbs, language, test validity. Validade e confiabilidade do teste de rastreio de doença de alzheimer com provérbios (trdaP) para idososresumo -A prevalência da doença de Alzheimer com o envelhecimento, que compromete memória, linguagem, funções executivas, praxia construtiva e abstração, necessita avaliação precoce com testes padronizados. Objetivo: Validação do Teste de Rastreio de Doença de Alzheimer com Provérbios (TRDAP), elaborado com pedras do jogo de memória de provérbios. Método: o teste contém três etapas (A: memória curto-prazo, B: funções executivas e linguagem e C: memória episódica). A amostra tinha 91 idosos com mínimos de 60 anos e de um ano de escolaridade, CDR (um ou zero), de serviços especializados da UFPE, HGA e particular. Avaliaram-se dados sociodemográficos, hábitos e percepção de saúde. Dentre os testes utilizados -MEEM (validade convergente), EDG (discriminante). Resultados: Apontaram para boa correlação com testes padronizados, consistência interna aceitável (0,71); ponto de corte por escolaridade foi 6,49 (80% e 77,8%) -baixa, e alta 8,66 (84,6% e 86,1%); coeficiente Kappa igual a 1 (p=0,000) inter-avaliadores. Conclusão: o TRDAP mostra-se válido para rastrear doença de Alzheimer.PAlAVRAS-CHAVE: doença de Alzheimer, provérbios, memória, linguagem, validade de testes.

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Encoding process in delayed recall impairment and rate of forgetting in Alzheimer's disease

Cited by 14 publications

References 19 publications

Memory consolidation in aging and MCI after 1 week.

Memory consolidation in aging and MCI after 1 week.

Alzheimer’s disease and memory strength: Gradual decline of memory traces as a function of their strength

Validity and reliability of the screening test for Alzheimer's disease with proverbs (STADP) for the elderly

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