Hepatic Steatosis Assessment:

Abstract

-Context -Liver transplantation is one of the last viable resources for patients with end-stage liver disease. Many strategies are been used to improve the number of available organs and overcome waiting list delay. However, hepatic steatosis is one of the mainly concerns when organs are consider to transplantation due to it is importance as a risk factor for primary dysfunction. Surgeons play an important role to decide each organ will be accept or decline and its righteous allocation. Objective -Retrospectively evaluate the surgeon assessment of steatosis degree and its confrontation with further histopathologic findings. Methods -We analyzed 117 patients underwent deceased liver transplantation for end-stage liver disease in University Hospital Walter Cantideo, Fortaleza, CE, Brazil. A matrix table was organized to estimate the categorical data observed. We clustered the subjects into mild (0%-30%) and moderate (30%-60%) steatosis degree under the clinical criteria of organ suitability for transplantation. We categorized the organs as suitable organ for transplant and as non-suitable organ for transplant. Evaluations between the two first assessments, before perfusion (pre-perfusion) vs biopsy findings and after perfusion vs biopsy findings observations were analyzed and also a comparison between pre-perfusion and after perfusion data was performed. Results -On the first assessment, we obtained a 93% of agreement (n = 109) between the two evaluations. On the second assessment, we had an 8% (n = 9) of mistaken allocation. Comparing the observation before (pre-perfusion) and after (after perfusion), we obtained a strong agreement between the surgeons. Conclusions -Although our experienced surgeon team, we have wrongly evaluated feasible organs for transplantation. Nonetheless, our faulty percentage is low comparing to worldwide percentage. HEADINGS -Fatty liver. Liver transplantation. Tissue and organ procurement. Tissue and organ havesting.

Significant Smartphone Images Features For Liver Steatosis Assesment

“…On the other hand, LBP P,R riu2 (eq. 9) were then computed on each of the three channels: 10 features from LBP 1,8 riu2 , 18 features from LBP 2,16 riu2 and 26 features from LBP 3,24 riu2 , wich gives a total of 3 × (10 + 18 + 26) LBP based features to a given image. Finally, rotation invariant RI LP Q were computed over three neighborhood sizes (M = 3;5;7) and the corresponding histograms were concatenated.…”

“…Liver transplantation (LT) provides indisputable benefit for the survival and quality of life of patients with end-stage diseases [1]. The advances in liver transplantation medicine have led to its expansion over the past ten years.…”

“…Even if biopsy samples are taken, visual assessment of liver steatosis remains very important and always performed. However, it depends on the experience of the surgeon and becomes sometimes very difficult even for experienced surgeons [1]. In this context, the development of a simple, handy, fast and accurate device for non-invasive quantification of HS would obviously be most desirable.…”

Steatosis and steatohepatitis found in adults after death due to non-burn trauma

“…Routine liver biopsy as a pretransplantation work-up is challenging because only over 20% of all liver transplants in the United Network for Organ Sharing (UNOS) have a recorded liver donor biopsy (5). The lack of liver donor biopsy is further worsened in settings in which histopathological services are not provided on a 24-hour basis in the transplantation centers (6). Thus, determining the actual prevalence and the risk factors for steatosis in the normal population may assist in stratifying the risk of steatosis in potential liver donors soon after harvesting the liver.…”