Ponto de corte do índice Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) avaliado pela curva Receiver Operating Characteristic (ROC) na detecção de síndrome metabólica em crianças pré-púberes com excesso de peso

Madeira, Isabel Rey; Carvalho, Cecília N. M.; Mussi, Fernanda Carneiro; Matos, Haroldo José de; Borges, Marcos Antonio; Bordallo, Maria Alice Neves

doi:10.1590/s0004-27302008000900010

Cited by 93 publications

(36 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As for skin color variable, 66.2% were nonwhite, corresponding to the findings of Wood et al (2009) [16], whose prevalence ranged from 63.3% in the obese group and 54.8% in the overweight group. Although in this study this variable was not analyzed according to the nutritional status, it appears that the prevalence remains high.…”

Section: Discussionsupporting

confidence: 81%

Lipoprotein (a) and Ultrasensitive C-Reactive Protein in Overweight Adolescents

Alves¹,

Farias²,

Costa³

et al. 2014

Health

View full text Add to dashboard Cite

2350= 0.273, p < 0.01) of u-CRP with BMI, which was not verified for lipoprotein (a). Conclusion: As a cardiovascular risk marker already established in literature, the association of u-CRP with the nutritional status of adolescents, proportionally, shows the need for losing weight in this population, especially at early age. A deeper and long-term investigation should be carried out for more effective and consistent contribution to public health.

show abstract

Section: Discussionsupporting

confidence: 81%

Lipoprotein (a) and Ultrasensitive C-Reactive Protein in Overweight Adolescents

Alves¹,

Farias²,

Costa³

et al. 2014

Health

View full text Add to dashboard Cite

show abstract

“…Some authors argue that there is no consensus regarding the ideal HOMA-IR cut-off value in children, and commercially available kits also measure pro-insulin levels (25). However, the HOMA-IR is reliable and practical, since it is standardized for a specific population as we chose, based on that of the study of Madeira and cols., whose data came from a cohort of children of similar age to ours and originating from Rio de Janeiro (15). Furthermore, results of HOMA-IR are strongly correlated with those obtained using the euglycemic hyperinsulinemic clamp (r = 0.82) and are thus considered reliable for epidemiologic studies on a large scale (26,27).…”

Section: Discussionsupporting

confidence: 64%

“…Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) was calculated (14) and the cut-off value ≥ 2.5 was chosen, based on the study of Madeira and cols. (15) in a cohort of the same age from Rio de Janeiro. Glucose and lipid profiles were determined by a colorimetric enzymatic method, using a Hitachi-Roche modular system (Roche Diagnostics GmbH, Mannheim, Germany).…”

Section: Laboratory Evaluationmentioning

confidence: 99%

2000 CDC or 2007 WHO – What is the most sensitive anthropometric reference for determination of overweight and cardio-metabolic risk in children aged 6–10 years?

Kuba¹,

Leone

Damiani

2015

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

Objective: To compare the two anthropometric standards for screening of overweight and cardiometabolic risk in 6-10-year-old children. Subjects and methods: This cross-sectional study included 175 subjects attending the Referral Center for the Treatment of Children and Adolescents in Campos, Rio de Janeiro. They were classified according to CDC and WHO BMI z scores as normal-weight (zscore > -1 and < 1), overweight (z-score ≥ 1 and < 2) or obese (z-score ≥ 2). Sensitivities and specificities in predicting systolic (SBP), diastolic (DBP) blood pressure and homeostatic model assessment insulin resistance index (HOMA-IR) alterations were calculated. Results: There was a major difference in 11 children who rated overweight by the CDC but were reclassified as obese by the WHO. Their mean z-scores for SBP (1.71 ± 1.54), DBP (2.64 ± 1.83) and HOMA-IR (1.84 ± 0.98) were higher than those classified as overweight by both references (SBP = 0.49 ± 1.34, p < 0.023, DBP = 1.45 ± 0.97, p < 0.04 and HOMA = 1.24 ± 0.67, p < 0.04), but were similar to those classified as obese by both criteria (SBP = 1.25 ± 2.04, p = 0.60, DBP = 1.94 ± 1.19, p = 0.50 and HOMA = 2.09 ± 1.12, p = 0.76). Conclusion: the 2007 WHO reference was the most sensitive in screening for overweight and alterations in blood pressure and HOMA-IR in 6-10-year-old children. Arch Endocrinol Metab. 2015;59(3):220-5

show abstract

“…There is still a debate about the appropriate cutoff point for HOMA-IR, with proposed values of ≥2.5,26,27 ≥1.77,28 and >3.16 20. Keskin et al20 found that HOMA-IR was the most sensitive and most specific of three proxies for defining insulin resistance, and the cutoff point for insulin resistance diagnosis based on HOMA-IR was 3.16,20 so that definition was used in the present study.…”

Section: Methodsmentioning

confidence: 94%

Prevalence of cardiometabolic risk factors and metabolic syndrome in obese Kuwaiti adolescents

Boodai¹,

Cherry²,

Sattar³

et al. 2014

DMSO

View full text Add to dashboard Cite

BackgroundChildhood and adolescent obesity is associated with insulin resistance, abnormal glucose metabolism, hypertension, dyslipidemia, inflammation, liver disease, and compromised vascular function. The purpose of this pilot study was to determine the prevalence of cardiometabolic risk factor abnormalities and metabolic syndrome (MetS) in a sample of obese Kuwaiti adolescents, as prevalence data might be helpful in improving engagement with obesity treatment in future.MethodsEighty obese Kuwaiti adolescents (40 males) with a mean (standard deviation) age of 12.3 years (1.1 years) participated in the present study. All participants had a detailed clinical examination and anthropometry, blood pressure taken, and assessment of fasting levels of C-reactive protein, intracellular adhesion molecule, interleukin-6, fasting blood glucose, insulin, liver function tests (alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase), lipid profile (cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides), insulin resistance by homeostasis model assessment, and adiponectin. MetS was assessed using two recognized criteria modified for use in younger individuals.ResultsThe cardiometabolic risk factors with highest prevalence of abnormal values included aspartate aminotransferase (88.7% of the sample) and insulin resistance by homeostasis model assessment (67.5%), intracellular adhesion molecule (66.5%), fasting insulin (43.5%), C-reactive protein (42.5%), low-density lipoprotein cholesterol (35.0%), total cholesterol (33.5%), and systolic blood pressure (30.0%). Of all participants, 96.3% (77/80) had at least one impaired cardiometabolic risk factor as well as obesity. Prevalence of MetS was 21.3% according to the International Diabetes Federation definition and 30% using the Third Adult Treatment Panel definition.ConclusionThe present study suggests that obese Kuwaiti adolescents have multiple cardiometabolic risk factor abnormalities. Future studies are needed to test the benefits of intervention in this high-risk group. They also suggest that prevention of obesity in children and adults should be a major public health goal in Kuwait.

show abstract

Ponto de corte do índice Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) avaliado pela curva Receiver Operating Characteristic (ROC) na detecção de síndrome metabólica em crianças pré-púberes com excesso de peso

Cited by 93 publications

References 42 publications

Lipoprotein (a) and Ultrasensitive C-Reactive Protein in Overweight Adolescents

Lipoprotein (a) and Ultrasensitive C-Reactive Protein in Overweight Adolescents

2000 CDC or 2007 WHO – What is the most sensitive anthropometric reference for determination of overweight and cardio-metabolic risk in children aged 6–10 years?

Prevalence of cardiometabolic risk factors and metabolic syndrome in obese Kuwaiti adolescents

Contact Info

Product

Resources

About