Leptina: o diálogo entre adipócitos e neurônios

Negrão, André Brooking; Licinio, Júlio

doi:10.1590/s0004-27302000000300004

Cited by 30 publications

(34 citation statements)

References 88 publications

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“…According to Negrão et al, 14 leptin levels can be influenced by glucocorticoids, such as cortisol, through stimulating the transcription of the leptin gene and also its production.…”

Section: Resultsmentioning

confidence: 99%

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The response of serum leptin, cortisol and zinc concentrations to concurrent training

Rosa¹,

Dantas²,

Mello³

2011

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ObjectIve: to investigate the effects of concurrent training (ct) on serum leptin, cortisol and zinc concentrations in physically active adults. DesIGN: ten subjects aged (27.1±4.8 years, bMI 25.49 ± 2.65) were recruited to participate in three sessions: control session (cs), concurrent training 1 (ct1) and concurrent training 2 (ct2) sessions with five days of resting between them. In each session blood samples for leptin, cortisol and zinc determination were collected. ct1 session included indoor cycling class followed by strength training. ct2 session included strength training, followed by indoor cycling class. In cs there were no exercises. the shapiro-Wilk test, repeated ANOvA test and tukey Post-Hoc test were used. resULts: there was a reduction in leptin levels after CT1 (Δ% = -16.04; p = 0.05) and CT2 (Δ% = -8.54; p = 0.02). Cortisol also showed a reduction after CT1 (Δ% = -26.32; p = 0.02) and CT2 (Δ% = -33.57; p = 0.05), whereas zinc did not show any significant alterations after any of the training sessions. there was also significant difference for the leptin and cortisol values between ct1 and ct2. cONcLUsIONs: ct promoted reduction in serum leptin and cortisol levels independently of the training order, while no significant changes in zinc concentrations were observed.

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“…According to Negrão et al, 14 leptin levels can be influenced by glucocorticoids, such as cortisol, through stimulating the transcription of the leptin gene and also its production.…”

Section: Resultsmentioning

confidence: 99%

“…13 Moreover, several factors exert a direct influence on leptin levels, such as glucocorticoids, physical exercise 14,15 and zinc. [16][17][18] Cortisol is a glucocorticoid secreted by the adrenal cortex and among other functions, increases glyconeogenesis and promotes fat mobilization and utilization.…”

Section: Introductionmentioning

confidence: 99%

The response of serum leptin, cortisol and zinc concentrations to concurrent training

Rosa¹,

Dantas²,

Mello³

2011

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“…Ambas, leptina e adiponectina, se correlacionaram nas respectivas análises de regressão multivariável, com HOMA-IR, apontado para a importância das adipocitoquinas na fisiopatologia da resistência insulínica, conforme destaca a literatura 7,8 .…”

Section: Variáveisunclassified

“…De forma oposta, diminuição do peso leva a menores níveis de leptina, e, assim, o hipotálamo responderia com aumento de ingestão de alimentos, diminuição de dispêndio energético e aumento de hormônios liberadores de corticotrofina, hormônio do crescimento e gonadotrofinas, além do aumento do tônus parassimpático 8 . Nos obesos são encontrados níveis elevados de leptina.…”

Section: Introductionunclassified

Impact of obesity on metabolic syndrome components and adipokines in prepubertal children

Madeira¹,

Carvalho²,

Mussi³

et al. 2009

J Pediatr (Rio J)

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Objective: To verify the impact of obesity on metabolic syndrome components and adipokine levels in prepubertal children. Methods:This cross-sectional study compared 30 obese, 31 overweight and 33 eutrophic children attending a university hospital-based outpatient pediatric clinic. Parameters assessed included glucose, serum lipids, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), glucose/insulin relation, adiponectin, and leptin. We compared the frequency of acanthosis nigricans and changes in waist, blood pressure, glucose, serum lipids, and insulin. The correlation between body mass index (BMI) z score and adipokines was evaluated.Results: Among obese children, there was a difference in the mean values of HDL cholesterol and adiponectin, whereas among the eutrophic children, there was a difference in the mean values of insulin, HOMA-IR, glucose/insulin relation, and leptin (p < 0.001). A difference was also observed regarding the frequency of acanthosis nigricans and alteration in waist and HDL cholesterol (p < 0.005) in the obese group. The BMI z score showed a positive correlation with leptin (p < 0.001) and a negative correlation with adiponectin (p = 0.001). In multiple linear regression, this correlation was maintained only for leptin; HDL-cholesterol correlated with adiponectin (p = 0.007) and HOMA-IR correlated with both variables (p < 0.05). Conclusion:These findings provide evidence of the influence of obesity on metabolic syndrome components and on adipokine levels in prepubertal children, indicating that these components may contribute to the beginning of cardiovascular diseases.J Pediatr (Rio J). 2009;85(3):261-268: Adiponectin, cardiovascular diseases, risk factors, homeostasis, body mass index, insulin, leptin, insulin resistance. ResumoObjetivo: Verificar o impacto da obesidade sobre os componentes da síndrome metabólica e sobre os níveis de adipocitoquinas em crianças pré-púberes. Métodos: Estudo transversal comparando 30 crianças obesas, 31com sobrepeso e 33 eutróficas, oriundas do ambulatório de pediatria geral de um hospital universitário, quanto às médias de glicose, lipídios séricos, insulina, HOMA-IR (homeostasis model assessment-insulin resistance), relação glicose/insulina, adiponectina e leptina. Compararam-se as frequências de acantose nigricans e das alterações de cintura, pressão arterial, glicose, lipídios séricos e insulina. Avaliou-se a correlação entre escore z de índice de massa corporal (IMC) e adipocitoquinas.Resultados: Houve diferença nas médias dos obesos, quanto a HDL-colesterol e adiponectina, e nas dos eutróficos, quanto a insulina, HOMA-IR, relação glicose/insulina e leptina (p < 0,001). O mesmo ocorreu em relação às frequências dos obesos quanto a acantose nigricans e alteração de cintura e HDL-colesterol (p < 0,005). O escore z de IMC se correlacionou positivamente com leptina (p < 0,001) e negativamente com adiponectina (p = 0,001). Na regressão linear múltipla, esta correlação se manteve apenas para leptina; o HDL-colesterol se correlaci...

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“…It is known as the "satiety hormone" for having influence on the appetite reduction process 3 . Its secretion may be influenced by many physiological mechanisms, such as fasting, the glucocorticoids, the sympathetic activity, physical exercise and alterations in the body weight and energetic balance, which can drastically alter the quantity of leptin intrinsically associated with fat mass 9 a fail in its production, and/or its activity over the receptors of the hypothalamus could distort the positive energetic balance, creating the obesity scenario 10 .…”

Section: Introductionmentioning

confidence: 99%

Efeitos agudos do treinamento concorrente sobre os níveis séricos de leptina e cortisol em adultos jovens sobrepesados

Cruz

Rosa

Valle

et al. 2012

Rev Bras Med Esporte

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Objective: This study aimed to analyze the immediate effects of concurrent training on leptin and cortisol levels in overweighed young adults. Methods: This study used a quasi-experimental methodology. We included 20 volunteers of both sexes, randomly divided into a training competitor group (TCG n = 10) and a control group (C n = 10). Blood collection was performed in individuals at rest after fasting for 12 hours. The leptin and cortisol levels were analyzed by radioimmunoassay and chemiluminescence immunoassay before and immediately after training. Two-way ANOVA was used for statistical analysis with a significance level of p <0.05. Results: In the analysis of leptin levels, there was significant difference between groups (TCG x C) in the pre intervention (p = 0.02) and post intervention (p = 0.01). In the intra groups, no significant changes were found, and in the analysis of cortisol levels between groups (TGC x C), a significant difference in the pre intervention (p = 0.01) and post intervention (p = 0.01) was observed; however, in the intra groups there were no significant changes. Conclusion: A single concurrent training session is not sufficient to promote acute changes in the leptin and cortisol levels of the volunteer overweighed young adults in this study.

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Leptina: o diálogo entre adipócitos e neurônios

Cited by 30 publications

References 88 publications

The response of serum leptin, cortisol and zinc concentrations to concurrent training

The response of serum leptin, cortisol and zinc concentrations to concurrent training

Impact of obesity on metabolic syndrome components and adipokines in prepubertal children

Efeitos agudos do treinamento concorrente sobre os níveis séricos de leptina e cortisol em adultos jovens sobrepesados

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