Patient safety culture from the perspective of all the workers of a general hospital

Kolankiewicz, Adriane Cristina Bernat; Schmidt, Catiele Raquel; Carvalho, Rhanna Emanuela Fontenele Lima de; Spies, Jacinta; Pai, Sandra Dal; Lorenzini, Elisiane

doi:10.1590/1983-1447.2020.20190177

Cited by 12 publications

(21 citation statements)

References 14 publications

(24 reference statements)

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“…We hypothesize that the X. maculatus allele of rab3d regulates cancer cell invasion by either mediating immune cell recruitment to tumor microenvironment or by hampering tumor cell secretion of molecules that facilitate metastasis. However, RAB3D function in cancer has not been clearly characterized despite efforts made investigating its function in cancer cell proliferation and metastasis in vitro (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83). Currently there is no understanding of the cell population within the Xiphophorus tumor microenvironment (e.g., tumor cells, endothelial cells, cancer-associated fibroblasts, and immune cells) where expression of different parental rab3d alleles may change the fundamental outcome of xmrk expression (84,85).…”

Section: Discussionmentioning

confidence: 99%

Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility

Liang

Sandoval

Voss

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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Mixing genomes of different species by hybridization can disrupt species-specific genetic interactions that were adapted and fixed within each species population. Such disruption can predispose the hybrids to abnormalities and disease that decrease the overall fitness of the hybrids and is therefore named as hybrid incompatibility. Interspecies hybridization between southern platyfish and green swordtails leads to lethal melanocyte tumorigenesis. This occurs in hybrids with tumor incidence following progeny ratio that is consistent with two-locus interaction, suggesting melanoma development is a result of negative epistasis. Such observations makeXiphophorusone of the only two vertebrate hybrid incompatibility examples in which interacting genes have been identified. One of the two interacting loci has been characterized as a mutant epidermal growth factor receptor. However, the other locus has not been identified despite over five decades of active research. Here we report the localization of the melanoma regulatory locus to a single gene,rab3d, which shows all expected features of the long-sought oncogene interacting locus. Our findings provide insights into the role ofegfrregulation in regard to cancer etiology. Finally, they provide a molecular explainable example of hybrid incompatibility.

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Section: Discussionmentioning

confidence: 99%

Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility

Liang

Sandoval

Voss

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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“…In the studies that investigated the safety environment, the safety domains that obtained the highest scores were job satisfaction (12,15,16,26,28,31,32), teamwork climate (16,23,28,30) and working conditions (21). In study 12, all the domains had a positive answer, except for the stress perception dimension.…”

Section: Resultsmentioning

confidence: 98%

“…Ten articles (13,14,17,18,20,22,24,25,27,33) used the HSOPSC questionnaire as data collection instrument; another ten articles (12,15,16,21,23,26,28,(30)(31)(32) used SAQ, and two (19,29) made use of PSCHO.…”

Section: Resultsmentioning

confidence: 99%

“…The objectives of the studies varied between investigating the interaction between the safety environment and the safety culture (14), analyzing the perception of the patient's safety environment by health professionals (15,29,31,32), investigating/ evaluating the patient safety culture (12,13,16,(26)(27)(28)33), assessing the perceptions about the patient safety culture among the health professionals (17-19, 21, 23, 24, 30), examining whether the safety culture has improved after the implementation of the patient safety program (22), assessing the associations between the dimensions of the patient safety culture and the perceived notification practices of safety events of varying severity (25), and investigating the relationships between dimensions of the patient safety culture in different cultures (20).…”

Section: Resultsmentioning

confidence: 99%

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Effect of the organizational culture for patient safety in the hospital setting: A systematic review

et al. 2021

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Objective: To identify the effect of the organizational culture on patient safety in the hospital context. Materials and methods: A systematic review, without meta-analysis, registered in PROSPERO with number CRD42020162981. Cross-sectional and observational studies were selected that assessed the safety environment and safety culture published between 2014 and 2020 in journals indexed in the EMBASE, Latin American and Caribbean Literature in Health Sciences (Literatura Latinoamericana e do Caribe em Ciências da Saúde, LILACS) via the Virtual Health Library (Biblioteca Virtual em Saúde, BVS), Medline (International Literature in Health Sciences) via PubMed, and Cumulative Index to Nursing and Allied Health Literature (CINAHL). Results: The findings show that a positive safety environment exerts a beneficial effect on the safety culture, favors the notification of events, and enables improvements in the quality of health care. Conclusions: The effective interaction between safety culture and organizational culture is still scarce in the literature. Most of the studies carried out investigate the situational diagnosis and little progress is made in terms of deepening the implications for the professional practice and the repercussions for the safety of hospitalized patients.

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“…Neste estudo, o domínio Satisfação no Trabalho apresentou maior escore entre os profissionais investigados. Esse achado assemelha-se ao encontrado em estudos desenvolvidos no Nordeste (Girão et al 2019) e Sul do Brasil (Pavan et al 2019;Kolankiewicz et al 2020). A satisfação profissional contribui para o desenvolvimento de atitudes positivas consigo e com os demais colegas de equipe, bem como favorece maior participação do profissional no seu contexto de trabalho (Pavan et al 2019).…”

Section: Discussionunclassified

Fatores associados aos domínios da cultura de segurança do paciente em unidades de perioperatório

Munhoz

Carneiro

Morais

et al. 2020

RSD

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Objective to analyze the factors associated with the domains of patient safety culture in perioperative units from the perspective of health professionals. Method: cross-sectional study, developed with 146 health professionals from perioperative units of a teaching hospital in Rio Grande do Sul, Brazil, from March to July 2018. Data were collected through the Brazilian version of the Safety Attitudes Questionnaire (SAQ), consisting of six domains. Values of means ≥75 points are considered to be a positive assessment of the safety culture. For data analysis, descriptive and bivariate statistics were used. Results: the domain that had the best evaluation among professionals was Job Satisfaction (score = 83.0). The Unit Management Perception (score = 55.2) and Hospital (score = 47.6) domains obtained the worst assessments. There was an association (p<0,05) between sex and the Hospital Management Perception domain; between having children and the domains of Job Satisfaction, Perception of Hospital Management and Working Conditions; and between satisfaction in the sector and the Domains of Teamwork and Job Satisfaction domains. Conclusion: it became evident that workers with children are more satisfied with the work and the conditions under which they work. Still, women have a negative perception of hospital management, as well as professionals with children and professionals with specialization/residency.

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Patient safety culture from the perspective of all the workers of a general hospital

Cited by 12 publications

References 14 publications

Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility

Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility

Effect of the organizational culture for patient safety in the hospital setting: A systematic review

Fatores associados aos domínios da cultura de segurança do paciente em unidades de perioperatório

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