An umbrella review on the effects of diabetes on implant failure and peri-implant diseases

Meza‐Mauricio, Jonathan; Miranda, Tamires Szeremeske; Almeida, Mariana Linhares; Silva, Helio Doyle; Figueiredo, Luciene Cristina; Duarte, Poliana Mendes

doi:10.1590/1807-3107bor-2019.vol33.0070

Cited by 20 publications

(13 citation statements)

References 30 publications

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“…In five studies, no clear conclusion could be drawn from the data obtained, so that the question of an increased risk was not answered [ 10 , 25 , 33 , 43 , 64 ]. However, the available aggregated literature consistently concluded that diabetes mellitus represents a risk factor for the development of peri-implant inflammation, although most studies point to a lack of high-quality and long-term studies on this research area [ 8 , 50 , 51 , 54 – 56 , 58 , 60 – 63 ].…”

Section: Resultsmentioning

confidence: 99%

“…For example, the study of Alberti et al [ 38 ] showed no significant difference of the implant survival after 10 years in patients with diabetes (survival rate of 96.5%) compared to patients without diabetes mellitus (survival rate of 94.8%), whereas the study of French et al [ 37 ] identified diabetes mellitus with a hazard ratio of 2.25 as a risk factor for implant failure in a multivariate analysis, implicating an over two times higher risk for failure of dental implants in patients with diabetes mellitus. In addition, eight aggregated literature references could be included on this question, whereby in seven publications, it was concluded that diabetes mellitus does not seem to have a significant influence on implant survival [ 8 , 51 , 52 , 55 – 58 , 63 ]. This includes two meta-analyses.…”

Section: Resultsmentioning

confidence: 99%

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Systematic review on diabetes mellitus and dental implants: an update

et al. 2022

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Purpose Dental implant surgery was developed to be the most suitable and comfortable instrument for dental and oral rehabilitation in the past decades, but with increasing numbers of inserted implants, complications are becoming more common. Diabetes mellitus as well as prediabetic conditions represent a common and increasing health problem (International Diabetes Federation in IDF Diabetes Atlas, International Diabetes Federation, Brussels, 2019) with extensive harmful effects on the entire organism [(Abiko and Selimovic in Bosnian J Basic Med Sci 10:186–191, 2010), (Khader et al., in J Diabetes Complicat 20:59–68, 2006, 10.1016/j.jdiacomp.2005.05.006)]. Hence, this study aimed to give an update on current literature on effects of prediabetes and diabetes mellitus on dental implant success. Methods A systematic literature research based on the PRISMA statement was conducted to answer the PICO question “Do diabetic patients with dental implants have a higher complication rate in comparison to healthy controls?”. We included 40 clinical studies and 16 publications of aggregated literature in this systematic review. Results We conclude that patients with poorly controlled diabetes mellitus suffer more often from peri-implantitis, especially in the post-implantation time. Moreover, these patients show higher implant loss rates than healthy individuals in long term. Whereas, under controlled conditions success rates are similar. Perioperative anti-infective therapy, such as the supportive administration of antibiotics and chlorhexidine, is the standard nowadays as it seems to improve implant success. Only few studies regarding dental implants in patients with prediabetic conditions are available, indicating a possible negative effect on developing peri-implant diseases but no influence on implant survival. Conclusion Dental implant procedures represent a safe way of oral rehabilitation in patients with prediabetes or diabetes mellitus, as long as appropriate precautions can be adhered to. Accordingly, under controlled conditions there is still no contraindication for dental implant surgery in patients with diabetes mellitus or prediabetic conditions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Systematic review on diabetes mellitus and dental implants: an update

et al. 2022

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“…Efectos del ejercicio físico en pacientes con fibromialgia (22) Diabetes mellitus y complicaciones en implantes dentales (24)…”

Section: Urunclassified

“…Los autores incluyeron 10 RS. En otro caso, Mauricio et al (24) resumieron la evidencia sobre las asociaciones entre diabetes mellitus y complicaciones en implantes dentales. Los autores incluyeron 20 RS y ningún estudio fue de alta calidad metodológica.…”

Section: Ejemplos De Autores Latinoamericanosunclassified

Revisiones de alcance, revisiones paraguas y síntesis enfocada en revisión de mapas: aspectos metodológicos y aplicaciones

Chambergo‐Michilot

Diaz-Barrera

Benítes-Zapata

2021

Rev Peru Med Exp Salud Publica

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Nuestro objetivo fue comentar las diferencias metodológicas y aplicaciones de tres nuevos tipos de revisiones con especial atención a Latinoamérica. Entre estos nuevos tipos de revisiones tenemos a las revisiones de alcance, revisiones paraguas y síntesis enfocada en revisión de mapas. Las revisiones de alcance identifican la naturaleza y extensión de la evidencia, las revisiones paraguas se centran en la síntesis de todas las revisiones sistemáticas que abordan un mismo problema de salud, mientras que las síntesis enfocadas en la revisión de mapas son opciones válidas cuando resulta inviable un mapeo clásico de la evidencia, por abordar demasiados artículos. En la medida de que los investigadores en Latinoamérica se familiaricen con la metodología y utilidad de estos nuevos tipos de revisión, se observará un incremento de la producción científica.

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“…In particular, excessive renal glucose reabsorption has been recognized as one of the main pathophysiological disorders in type 2 DM and a specific class of hypoglycemic agents SGLT2 inhibitors is now widely used to mitigate this phenomenon [14], in nerves, heart, and blood vessels [15][16][17][18]. It therefore represents a risk factor for many systemic and local pathologies including peri-implantitis [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis

Dioguardi

Cantore

Scacco

et al. 2022

JPM

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Background and objective: Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia resulting from impaired secretion or action of insulin. The high levels of glucose in the blood can negatively affect the healing processes through alterations in vascularization, bone remodeling, and with increased susceptibility to infections. Diabetes mellitus is therefore a risk factor not only for many systemic diseases, but also for localized problems such as peri-implantitis. The objective of this systematic review was to identify a clear relationship between peri-implant inflammation indices and glycemic levels, through the investigation of prospective studies that report data on a short-term follow-up period. Our hypothesis was that peri-implant inflammatory indices may already present themselves in a statistically significant way as altered in patients with DM compared to patients without DM. Materials and methods: This review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Results: More than 992 records were identified in the PubMed, Scopus, and Cochrane Central Register of Controlled Trial electronic databases and only seven studies were included in the meta-analysis. The results of the meta-analysis report worse outcomes in patients with DM, even in the short period of six months, for peri-implatitis inflammation indices, such as Marginal bone loss (standardized (Std). mean difference (MD) 12\6 months 0.81 [0.45, 1.17]\1.82 [0.53, 3.10]), Bleeding on probing (Std. MD 12\6 months 2.84 [1.34, 4.34]\3.44 [1.41, 5.50]), Probing depth (Std. MD 12\6 months 1.14 [0.60, 1.68]\2.24 [0.66, 3.83]), and the plaque index (Std. MD 12 months 2.83 [0.09, 5.57]). Conclusion: The literature linking glycaemic control to peri-implant disease is highly heterogeneous due to lack of consistency of the definition of peri-implantitis and its clinical indicators among studies. Therefore, interpretation of finding and relevance to clinical practice should be considered on individual bases. In the era of personalized medicine, the clinician should utilize individualized information from translational researches and analyze all risk factors to provide the patient with evidence-based treatment options.

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An umbrella review on the effects of diabetes on implant failure and peri-implant diseases

Abstract: Tamires Szeremeske MIRANDA (a) Mariana Linhares ALMEIDA (a) Helio Doyle SILVA (a) Luciene Cristina FIGUEIREDO (a) Poliana Mendes DUARTE (a)

Cited by 20 publications

References 30 publications

Systematic review on diabetes mellitus and dental implants: an update

Systematic review on diabetes mellitus and dental implants: an update

Revisiones de alcance, revisiones paraguas y síntesis enfocada en revisión de mapas: aspectos metodológicos y aplicaciones

From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis

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