From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis

Abstract

Background and objective: Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia resulting from impaired secretion or action of insulin. The high levels of glucose in the blood can negatively affect the healing processes through alterations in vascularization, bone remodeling, and with increased susceptibility to infections. Diabetes mellitus is therefore a risk factor not only for many systemic diseases, but also for localized problems such as peri-implantitis. The objective of this systematic review was to identify a clear relationship between peri-implant inflammation indices and glycemic levels, through the investigation of prospective studies that report data on a short-term follow-up period. Our hypothesis was that peri-implant inflammatory indices may already present themselves in a statistically significant way as altered in patients with DM compared to patients without DM. Materials and methods: This review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Results: More than 992 records were identified in the PubMed, Scopus, and Cochrane Central Register of Controlled Trial electronic databases and only seven studies were included in the meta-analysis. The results of the meta-analysis report worse outcomes in patients with DM, even in the short period of six months, for peri-implatitis inflammation indices, such as Marginal bone loss (standardized (Std). mean difference (MD) 12\6 months 0.81 [0.45, 1.17]\1.82 [0.53, 3.10]), Bleeding on probing (Std. MD 12\6 months 2.84 [1.34, 4.34]\3.44 [1.41, 5.50]), Probing depth (Std. MD 12\6 months 1.14 [0.60, 1.68]\2.24 [0.66, 3.83]), and the plaque index (Std. MD 12 months 2.83 [0.09, 5.57]). Conclusion: The literature linking glycaemic control to peri-implant disease is highly heterogeneous due to lack of consistency of the definition of peri-implantitis and its clinical indicators among studies. Therefore, interpretation of finding and relevance to clinical practice should be considered on individual bases. In the era of personalized medicine, the clinician should utilize individualized information from translational researches and analyze all risk factors to provide the patient with evidence-based treatment options.

Instigating the in vitro antidiabetic activity of new tridentate Schiff base ligand appended M(II) complexes: From synthesis, structural characterization, quantum computational calculations to molecular docking, and molecular dynamics simulation studies

“…[3] DM refers to an umbrella term used for a group of disorders characterized by chronic hyperglycaemia stemming from inadequate insulin secretion or insulin resistance. [4] Hyperglycaemia is usually associated with symptoms such as fatigue, thirst, frequent urination, recurring infections, blurred vision, and dysfunction of a variety of organs including the kidneys, blood vessels, heart, and nerves. [5,6] Diabetes is primarily classified into two types; Type-I and Type-II.…”

Is the Non-Coding RNA miR-195 a Biodynamic Marker in the Pathogenesis of Head and Neck Squamous Cell Carcinoma? A Prognostic Meta-Analysis

“…The planning of this systematic review and meta-analysis was performed according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions, and following the indications of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) [ 18 , 19 , 20 , 24 , 25 , 26 , 27 ] The review protocol was previously registered on INPLASY (International Platform of Registered Systematic Review and Meta-analysis Protocols) with registration number INPLASY202240150 and the DOI is 10.37766/inplasy2022.4.0150.…”

Photodynamic Therapy for Peri-Implant Diseases

“…However, PDT plus mechanical debridement failed to reduce a large number of subgingival microbial species in another report [ 141 ]. Despite some investigations contradicting each other about the influence of diabetes mellitus on peri-implantitis and showing inability to establish a definitive association [ 142 , 143 , 144 ], the emphasis on diabetes mellitus as a risk for peri-implantitis has been recognized [ 145 , 146 ]. The efficacy of PDT in improving clinical peri-implant disease parameters, pro-inflammatory biomarkers and microbiological profiles has been reported [ 132 , 147 , 148 , 149 ].…”