Vitamin D serum levels and peripheral arterial disease among southern Brazilian adults

SUMMARY OBJECTIVE: This study aimed to investigate the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) expression and its role in cytokine production from peripheral blood mononuclear cells (PBMCs) in patients with coronary artery disease (CAD) and non-CAD participants (NCAD). METHODS: Blood samples were taken from 15 patients with CAD and 15 NCAD individuals. The plasma was used for biochemical analyses. MALAT1 and CD36 expressions were evaluated in the isolated peripheral blood mononuclear cells (PBMCs) by real-time PCR. Furthermore, the levels of inflammatory cytokines e.g. interleukin (IL)-6, IL-10, and IL-22 were measured in the supernatants of the cultured PBMCs by flow cytometry. RESULTS: The levels of MALAT1 and CD36 were not significantly different between the CAD and NCAD groups. However, a lower level of MALAT1 and CD36 was observed in PBMCs of vitamin D deficient (<15 ng/ml) CAD and NCAD participants. Furthermore, the vitamin D deficient (<15 ng/ml) group showed a significantly higher plasma level of IL-6, IL-10, and IL-22 compared to the non-deficient (≥15 ng/ml) group. In addition, significant positive correlations were found between CD36, IL-22, and fasting blood sugar (FBS) with MALAT1. CONCLUSION: Given that in vitamin D deficient individuals a decreased level of MALAT1 was associated with CD36 expression and increased IL-22 production, vitamin D supplementation may play a role in reducing MALAT1/CD36/IL-22 mediated complications such as T2DM and CAD, especially in vitamin D deficiency.

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Vitamin D status influences cytokine production and MALAT1 expression from the PBMCs of patients with coronary artery disease and healthy controls

Nowrouzi-Sohrabi

Kalani

Izadpanah

et al. 2020

Rev. Assoc. Med. Bras.

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Role of Vitamin D in Peripheral Vascular Diseases

Tripathi

Singh

Kumar³

2021

IJAR

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BACKGROUND – Peripheral vascular disease (PVD) is currently a leading cause of morbidity and mortality. More than 200 million people globally have been estimated to be affected by PVD. Recent evidence has shown that Vitamin D deciency plays a causal role in various systemic disorders specially in PVD. Vitamin D deciency affects almost 50% of the population worldwide. Low serum 25-hydroxyvitamin D levels were particularly associated with a higher prevalence of PVD. OBJECTIVE –To study the relation between serum Vitamin D levels and peripheral vascular diseases. MATERIAL AND METHODS – Study subjects comprised 100 patients of Peripheral Vascular Disease, aged 18 - 70 years, enrolled from OPD and indoor of L.P.S. Institute of Cardiology & K.P.S Institute of Medicine. Their detailed physical examination and investigations was done including serum vitamin D levels. RESULTS – The results showed that majority of the patients (70%) with PVD were having vitamin D deciency (S. Vit D <20ng/ml). The prevalence of PVD increases with increasing age of the subjects but the association was statistically insignicant. There was no signicant association of PVD with any socio-demographic factors. CONCLUSION – The study showed that vitamin D deciency was present in majority of subjects (70%) establishing its signicant association with PVD (p<0.05).

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Vitamin D serum levels and peripheral arterial disease among southern Brazilian adults

Cited by 2 publications

References 19 publications

Vitamin D status influences cytokine production and MALAT1 expression from the PBMCs of patients with coronary artery disease and healthy controls

Vitamin D status influences cytokine production and MALAT1 expression from the PBMCs of patients with coronary artery disease and healthy controls

Role of Vitamin D in Peripheral Vascular Diseases

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