Role of Vitamin D in Peripheral Vascular Diseases

Abstract

BACKGROUND – Peripheral vascular disease (PVD) is currently a leading cause of morbidity and mortality. More than 200 million people globally have been estimated to be affected by PVD. Recent evidence has shown that Vitamin D deciency plays a causal role in various systemic disorders specially in PVD. Vitamin D deciency affects almost 50% of the population worldwide. Low serum 25-hydroxyvitamin D levels were particularly associated with a higher prevalence of PVD. OBJECTIVE –To study the relation between serum Vitamin D levels and peripheral vascular diseases. MATERIAL AND METHODS – Study subjects comprised 100 patients of Peripheral Vascular Disease, aged 18 - 70 years, enrolled from OPD and indoor of L.P.S. Institute of Cardiology & K.P.S Institute of Medicine. Their detailed physical examination and investigations was done including serum vitamin D levels. RESULTS – The results showed that majority of the patients (70%) with PVD were having vitamin D deciency (S. Vit D <20ng/ml). The prevalence of PVD increases with increasing age of the subjects but the association was statistically insignicant. There was no signicant association of PVD with any socio-demographic factors. CONCLUSION – The study showed that vitamin D deciency was present in majority of subjects (70%) establishing its signicant association with PVD (p<0.05).