BACKGROUND – Peripheral vascular disease (PVD) is currently a leading cause of morbidity and mortality. More than 200 million people globally have been estimated to be affected by PVD. Recent evidence has shown that Vitamin D deciency plays a causal role in various systemic disorders specially in PVD. Vitamin D deciency affects almost 50% of the population worldwide. Low serum 25-hydroxyvitamin D levels were particularly associated with a higher prevalence of PVD. OBJECTIVE –To study the relation between serum Vitamin D levels and peripheral vascular diseases. MATERIAL AND METHODS – Study subjects comprised 100 patients of Peripheral Vascular Disease, aged 18 - 70 years, enrolled from OPD and indoor of L.P.S. Institute of Cardiology & K.P.S Institute of Medicine. Their detailed physical examination and investigations was done including serum vitamin D levels. RESULTS – The results showed that majority of the patients (70%) with PVD were having vitamin D deciency (S. Vit D <20ng/ml). The prevalence of PVD increases with increasing age of the subjects but the association was statistically insignicant. There was no signicant association of PVD with any socio-demographic factors. CONCLUSION – The study showed that vitamin D deciency was present in majority of subjects (70%) establishing its signicant association with PVD (p<0.05).
Background: Peripheral artery disease (PAD) is due to abnormal Narrowing of arteries other than heart and brain (primarily due to atherosclerosis). PAD is the most common form of PVD. Aims and Objectives: In the present study, we analyzed Vitamin D association with peripheral vascular diseases as well as coagulation and inflammation parameters. Materials and Methods: The study was conducted for 100 PAD patients of 18–70 years age and divided in Group I≤20ng/ml and Group II>20ng/ml for serum Vitamin D level. A single, oral, and high- dose Vitamin D3 supplementation 1,20,000IU was given in GroupI. At baseline and at the end of the study after 1 month, Ankle Brachial Index, modified Rankin Scale, Vitamin D, Inflammation and coagulation parameter, HbA1c, etc., were performed in all patients. Evaluation was done using SPSS. The level P<0.05 was considered as the cut off value of significance. Results: The majority of the PAD patients were Vitamin D deficient and have higher HbA1c level with statistically significant (P<0.05) association. This is because low Vitamin D is the risk factor for diabetes in which HbA1c level is higher. Conclusion: Asingle, oral, and high-dose Vitamin D3 supplementation did not alter parameters of inflammation and hemostasis in patients with peripheral arterial disease, adding more data to other studies that did not confirm a causal role of Vitamin D in cardiovascular disease.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.