The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate

Kuduban, Ozan; Mazlumoglu, Muhammet Recai; Kuduban, Selma Denktas; Erhan, Ertuğrul; Cetin, Nihal; Kukula, Osman; Yaralı, Oğuzhan; Çimen, Ferda Keskin; Çankaya, Murat

doi:10.1590/1678-775720160139

Cited by 14 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…32,33 The findings of the present study were in line with other studies that reported similar changes in tongue mucosa of experimental rats induced by other cytotoxic drugs such as 5-Fluorouracil 34 and methotrexate. 35 In addition, a more recent study showed that irinotecan administration in rats led to an intestinal mucosal damage that was manifested by disorganized epithelial architecture, epithelial damage, atrophy of the villi and inflammatory cellular infiltration. They suggested that the oxidative stress was the main mechanism of irinotecan-induced mucosal toxicity.…”

Section: Discussionmentioning

confidence: 99%

Effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood

Ibrahim

Elwan

2019

Int J Experimental Path

View full text Add to dashboard Cite

Summary Irinotecan is one of the most important anti‐tumour drugs against a broad spectrum of malignancies, but is known to be associated with possible oral complications. The aim of the present study was to evaluate the effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood using different histological and immunohistochemical methods. Twenty juvenile male albino rats were divided equally into two groups: control and irinotecan‐treated group (single injection of 200 mg irinotecan/kg, then kept for four weeks without treatment). The tongue specimens were processed for light microscopy and scanning electron microscopy. The irinotecan‐treated group showed statistically significant shortening and thinning of the lingual papillae. There was loss of the normal appearance of the filiform papillae with focal cell loss alternating with areas of hyperkeratosis. Focal separation of the keratin layer, some nuclear changes and vacuolation of some epithelial cells were detected. Dilated congested blood vessels and mild mononuclear cellular infiltration were encountered. Atrophic fungiform papillae with ill‐defined taste bud cells were observed. A statistically significant decrease in the pattern of Ki67 immunohistochemical staining reaction was detected in comparision to the control group. Scanning electron microscopy revealed different signs of atrophy of the tongue papillae. Focal areas of desquamation of lingual papillae were observed revealing some filiform papillae with desquamated surface, bisected tips and evident thinning. Some extravasated red blood cells could be detected. Thus irinotecan caused significant morphological and morphometrical alterations of the tongue mucosa in particularly the filiform papillae.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood

Ibrahim

Elwan

2019

Int J Experimental Path

View full text Add to dashboard Cite

show abstract

“…WHO and worldwide regulatory agencies, including FDA, the Canada Vigilance Program, and ANVISA, are working towards setting up current standards and regulations for herbal medicinal products [59][60][61][62][63]. To have new efficacious NHP approved, preclinical studies using plant-derived extracts in animal models, including tests for OM induced by radio-chemotherapy are being performed [64][65][66][67][68][69][70][71][72][73][74].…”

Section: Medicinal Herb Derivativesmentioning

confidence: 99%

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

et al. 2021

View full text Add to dashboard Cite

Clinical guidelines for oral mucositis (OM) still consist in palliative care. Herein, we summarize cellular and molecular mechanisms of OM ulceration in response to chemical therapies in animal models. We discuss evidenced anti-inflammatory and anti-oxidant drugs which have not been ever used for OM, such as synthetic peptides as well as cell therapy with mesenchymal stem cells; amniotic membranes, mucoadhesive polymers loaded with anti-inflammatory agents and natural or synthetic electrospun. These approaches have been promising to allow the production of drugloaded membranes, scaffolds for cells encapsulation or guided tissue regeneration.

show abstract

“…), honey, Traumeel S, water grass decoction, and Weleda Ratanhia, also showed similar effects on the alleviation of OM via anti-inflammation activities [17,[63][64][65][66][67][68][69][70][71][72]. The bioactive properties of the yarrow plant (Achillea mileofolium), honey, Callendula officinalis flowers, Hipophae rhamnoides L. plant, Chamomile, and Aloe vera were associated with antioxidant, anti-inflammatory, antibacterial, and wound healing effects of oral mucositis therapy (Table 4) [64][65][66][72][73][74][75][76][77]. Similar to the advantages of the medical-biological activities of these herbal agents, C. osmophloeum would provide an identical mechanism for relieving oral mucositis.…”

Section: Potential Use Of C Osmophloeum For the Treatment Of Oral Mumentioning

confidence: 99%

Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

et al. 2020

View full text Add to dashboard Cite

The aim of this review was to provide an updated overview of studies on the medical-biological activities of Cinnamomum osmophloeum (C. osmophloeum) in vitro and in vivo and the potential therapeutic use of natural agents prepared from this plant for the alleviation of oral mucositis (OM). Reported articles were collected using web search engine tools. The systematic review was organized according to the preferred reporting items for reviews and meta-analyses (PRISMA) statement. Additional sources were identified through cross-referencing to identify the potential use of C. osmophloeum in the alleviation of OM. The results disclosed that C. osmophloeum is comprised of bioactive ingredients that could act diversely as a reagent in anti-inflammation, antibacterial, antioxidant, anti-hyperglycemic, antidyslipidemia, anti-cancer, renal disease therapy and anti-hyperuricemia capacities. Recent studies revealed that the overall effects on anti-inflammation, wound repair, and the antibacterial and antioxidant activities of its constituents would act as a potential remedy for oral mucositis. Up-to-date in vitro and in vivo studies on the medical-biological activities of C. osmophloeum suggested that C. osmophloeum and its constituents could be promising remedies as adjuvants in OM therapy and warrant further investigation.

show abstract

The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate

Cited by 14 publications

References 29 publications

Effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood

Effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

Contact Info

Product

Resources

About