We determined that laryngeal cancer was associated with oxidative stress, which may be quantified by measuring 8-hydroxy-2'-deoxyguanosine. For a patient with a suspicious laryngeal lesion, 8-hydroxy-2'-deoxyguanosine levels in blood and urine can provide advance information about the likely diagnosis.
Objective. The aim of this study was to evaluate the effectiveness of thiamine pyrophosphate against cisplatin-induced ototoxicity in guinea pigs. Materials and Methods. Healthy guinea pigs (n = 18) were randomly divided into three groups. Group 1 (n = 6) received an intraperitoneal injection of saline solution and cisplatin for 7 days, group 2 (n = 6) received an intraperitoneal injection of thiamine pyrophosphate and cisplatin for 7 days, and group 3 (n = 6) received only intraperitoneal injection of saline for 7 days. The animals in all groups were sacrificed under anesthesia, and their cochleas were harvested for morphological and biochemical observations. Results. In group 1, receiving only cisplatin, cochlear glutathione concentrations, superoxide dismutase, and glutathione peroxidase activities significantly decreased (P < 0.05) and malondialdehyde concentrations significantly increased (P < 0.05) compared to the control group. In group 2, receiving thiamine pyrophosphate and cisplatin, the concentrations of enzymes were near those of the control group. Microscopic examination showed that outer hair cells, spiral ganglion cells, and stria vascularis were preserved in group 2. Conclusion. Systemic administration of thiamine pyrophosphate yielded statistically significant protection to the cochlea of guinea pigs from cisplatin toxicity. Further experimental animal studies are essential to determine the appropriate indications of thiamine pyrophosphate before clinical use.
Objective: The objective of this study was to evaluate the causes of persistent nasal obstruction of patients after septoplasty.
Materials and Methods:After exclusion of allergic rhinitis, nonallergic rhinitis and nasal polyposis, this study included 90 patients with nasal breathing problem who underwent septoplasty at least 4 months ago. After taking full history and completing otorhinological and endoscopic examination, all patients graded their extent of obstruction using the Nasal Obstruction Symptoms Evaluation scale.
Results:Our results showed only 45% of patients' persist septal deviation; besides other obstructive pathologies, 55% were detected after detailed otolaryngologic evaluation.
Conclusion:Therefore, septal surgeons need to observe all obstructive causes of the nose carefully before planning the procedure.Keywords: Nasal obstruction, septoplasty, endoscopic, rhinitis Özet Amaç: Bu çalışmanın amacı septum cerrahisi geçirmiş olmasına rağ-men burun tıkanıklığı şikayeti devam eden hastalarda buna neden olan durumun veya durumların değerlendirilmesidir.
Gereç ve Yöntem:Alerjik rinit, non-alerjik rinit ve nazal polipozis hastalığı olmayan ve septum cerrahisi geçirme hikayesine sahip 90 hasta çalışmaya dahil edildi. Hastalar anamnezleri alınıp otolaringolojik muayeneleri yapıldıktan sonra ''Nasal Obstruction Evaluation'' skalası ile değerlendirildiler.
Bulgular:Hastaların %45'inde persiste eden nazal septum deviasyonu saptandı. Diğer %55'inde de obstrüksiyona yapan diğer nedenler gözlemlendi.Sonuç: Sonuç olarak septum cerrahisi ile uğraşan cerrahların ameliyat öncesi obstrüksiyona neden olabilecek tüm nedenleri saptaması ve cerrahi planlamanın buna göre yapılması hastayı ikinci bir nazal cerrahiden koruyacaktır.
Articaine is a safe local anesthetic agent with rapid onset of action. When compared with lidocaine, it is associated with improved tissue diffusion, rare postoperative complications, and less postoperative pain, thus, representing a safe and effective local anesthetic agent for septoplasty procedure.
To investigate the effect of HRE (Hippophae rhamnoides extract) on oral mucositis induced in rats with MTX. Material and Methods: Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg HRE while MTXC and HG groups received equivolume distilled water with gavage once a day. After one hour of HRE and distilled water administration, HMTX and MTXC groups received a single dose of oral MTX 5 mg/ TNFanimals receiving MTX, compared with HG and HMTX groups; however, these parameters were lower in the cheek and low lip tissue, and a milder damage ocurred in these tissues, compared with the tongue tissue in MTXC group. No histopathologic damage was observed in the cheek, lower lip, and tongue tissues of the rats treated with HRE. Conclusion: This synthetic drugs for prophylaxis of oral mucositis developed due to MTX.
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