Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

Bakar, Abu; Yao, Pin-Chuan; Ningrum, Valendriyani; Liu, Cheng-Tzu; Lee, Shih‐Chieh

doi:10.3390/biomedicines8010003

Cited by 13 publications

(10 citation statements)

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“…Disturbed sleep in adult and elderly individuals has been increasingly recognized as a risk factor for depression. 9 , 10 , 11 , 12 , 13 , 14 Consequently, sleep has been the target of several selective and indicated depression prevention programs, with promising results. 15 …”

Section: Introductionmentioning

confidence: 99%

Association Between Disturbed Sleep and Depression in Children and Youths

et al. 2021

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IMPORTANCE Disturbed sleep represents a potentially modifiable risk factor for depression in children and youths that can be targeted in prevention programs. OBJECTIVE To evaluate the association between disturbed sleep and depression in children and youths using meta-analytic methods. DATA SOURCES Embase, MEDLINE, PsycINFO, Scopus, Web of Science, and ProQuest Dissertations & Theses Global were searched for articles published from 1980 to August 2019. STUDY SELECTION Prospective cohort studies reporting estimates, adjusted for baseline depression, of the association between disturbed sleep and depression in 5-to 24-year-old participants from community and clinical-based samples with any comorbid diagnosis. Case series and reports, systematic reviews, meta-analyses, and treatment, theoretical, and position studies were excluded. A total of 8700 studies met the selection criteria. This study adhered to the guidelines of the Preferred Reporting Items for Systematic Reviews (PRISMA) and Meta-analyses and the Meta-analysis of Observational Studies in Epidemiology (MOOSE) statements. DATA EXTRACTION AND SYNTHESIS Study screening and data extraction were conducted by 2 authors at all stages. To pool effect estimates, a fixed-effect model was used if I 2 < 50%; otherwise, a random-effects model was used. The I 2 statistic was used to assess heterogeneity. The risk of bias was assessed using the Research Triangle Institute Item Bank tool. Metaregression analyses were used to explore the heterogeneity associated with type of ascertainment, type of and assessment tool for disturbed sleep and depression, follow-up duration, disturbed sleep at follow-up, and age at baseline. MAIN OUTCOME AND MEASURES Disturbed sleep included sleep disturbances or insomnia. Depression included depressive disorders or dimensional constructs of depression. Covariates included age, sex, and sociodemographic variables. RESULTS A total of 22 studies (including 28 895 patients) were included in the study, of which 16 (including 27 073 patients) were included in the meta-analysis. The pooled β coefficient of the association between disturbed sleep and depression was 0.11 (95% CI, 0.06-0.15; P < .001; n = 14 067; I 2 = 50.8%), and the pooled odds ratio of depression in those with vs without disturbed sleep was 1.50 (95% CI, 1.13-2.00; P = .005; n = 13 006; I 2 = 87.7%). Metaregression and sensitivity analyses showed no evidence that pooled estimates differed across any covariate. Substantial publication bias was found. (continued) Key Points Question Is disturbed sleep associated with depression in children and youths? Findings In this meta-analysis of 16 studies including 27 073 patients, pooled estimates supported the role of disturbed sleep as a risk factor for depression in children and youths. Effect size estimates were small but statistically significant. Meaning This study suggests that disturbed sleep is a component of the multifaceted risk profile of depression and should be included in prevention programs as early as childhood.

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Section: Introductionmentioning

confidence: 99%

Association Between Disturbed Sleep and Depression in Children and Youths

et al. 2021

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“…Since all phytochemicals used in this study were known to have antioxidant activity [30][31][32][33][34][35][36][37][38][39], we considered that almost all of the 10 phytochemicals would also exhibit antioxidant activity in zebrafish larvae. However, only five showed protective effects against H 2 O 2 toxicity, including isoeugenol and 6-MSITC, which showed only slight effects ( Figure 6, black triangles), in addition to curcumin, diallyl trisulfide and quercetin.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant Activity of Spice-Derived Phytochemicals Using Zebrafish

Endo

Muraki

Fuse

2020

IJMS

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Various dietary phytochemicals seem to display antioxidant activity through the NF-E2-related factor 2 (Nrf2) pathway. However, few studies have demonstrated its antioxidant effect and Nrf2 dependency at the animal level. We constructed a zebrafish-based assay system to analyze the in vivo antioxidant activity of phytochemicals and examined the activity of 10 phytochemicals derived from spices, using this system as a pilot study. Hydrogen peroxide and arsenite were used as oxidative stressors, and Nrf2 dependency was genetically analyzed using an Nrf2-mutant zebrafish line. The activities of curcumin, diallyl trisulfide and quercetin were involved in the reduction of hydrogen peroxide toxicity, while those of cinnamaldehyde, isoeugenol and 6-(methylsulfinyl)hexyl isothiocyanate were involved in the reduction of arsenite toxicity. The antioxidant activities of these phytochemicals were all Nrf2 dependent, with the exception of cinnamaldehyde, which showed strong antioxidant effects even in Nrf2-mutant zebrafish. In summary, we succeeded in constructing an assay system to evaluate the in vivo antioxidant activity of various phytochemicals using zebrafish larvae. Using this system, we found that each spice-derived phytochemical has its own specific property and mechanism of antioxidant action.

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“…In order to inhibit the growth and proliferation of pathogenic microorganisms, synthetic drugs have been commonly used for Bakar et al (2020) the treatment of microbial infections. The overuse of conventional antibacterial drugs could lead to serious side effects, including the selection of resistant bacterial strains and the development of antibiotic resistance during treatment, posing a real threat to global public health (Russell, 2002;Goyal et al, 2008;Cȃlina et al, 2017;Ungureanu et al, 2017;Zlatian et al, 2018).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits

Sharifi‐Rad

Dey

Koirala³

et al. 2021

Front. Pharmacol.

103

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The genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for a long time. Different traditional healing systems have used these plants as herbal remedies to cure diverse ailments. The aim of this comprehensive and updated review is to summarize the biodiversity of the genus Cinnamomum, its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety. All the data in this review have been collected from databases and recent scientific literature including Web of Science, PubMed, ScienceDirect etc. The results showed that the bioactive compounds of Cinnamomum species possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer and neuroprotective effects. The preclinical (in vitro/in vivo) studies provided the possible molecular mechanisms of these action. As a novelty, recent clinical studies and toxicological data described in this paper support and confirm the pharmacological importance of the genus Cinnamomum. In conclusion, the obtained results from preclinical studies and clinical trials, as well as reduced side effects provide insights into future research of new drugs based on extracts and bioactive compounds from Cinnamomum plants.

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Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

Cited by 13 publications

References 91 publications

Association Between Disturbed Sleep and Depression in Children and Youths

Association Between Disturbed Sleep and Depression in Children and Youths

Evaluation of Antioxidant Activity of Spice-Derived Phytochemicals Using Zebrafish

Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits

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