Hydroxyapatite, polycaprolactone and alendronate composites for bone regeneration in rabbits' olecranon: histological features

Valente, Fabrício Luciani; Reis, Emily Correna Carlo; Sepúlveda, Rodrigo Viana; Ochoa, Carla Contreras; Santos, Luiz Carlos Oliveira dos; Corsini, Camila Maria Mantovani; Borges, Andréa Pacheco Batista

doi:10.1590/1678-4162-8343

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Whereas the osteoconduction, which is characterized as the ability to drive or direct the neobone formation over and between the structure of the filling material, was not observed in most groups and, in particular, in the group where the rod is formed only with polymer, fact which differs from results found in the literature 16,17 , for example, Nacer et al…”

contrasting

confidence: 72%

Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

Santos

Facco

Ortiz³

et al. 2017

Acta Cir. Bras.

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IVBehavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal 1 4-Experimental SurgeryActa Cir Bras. 2017;32(2):116-124 AbstractPurpose: To evaluate the polymer doped rods behavior with bioactive glass and hydroxyapatite for possible application as a fracture fixing method. Methods: Twenty eight Rattus norvegicus Wistar underwent bone defect for access to the femoral medullary canal and distributed into three experimental groups: group A -doped castor bean polymer with bioactive glass; group B -castor bean polymer and; group C -castor bean polymer doped with bioactive glass and hydroxyapatite. After 15 and 60 evaluation days, the femurs were removed and sent for histology and scanning electron microscopy. Results: Initially mild and moderate inflammatory infiltrate is observed that decreases as time goes by, and the presence of connective tissue capsule around the graft in all groups. Regarding the biomaterials resorption little was observed. The implanted rods did not favor the osteoconductive process in the femoral medullary canal which was observed only in the C15 group. Conclusion:The association of castor bean polymer, bioactive glass and hydroxyapatite was biocompatible and osteointegrable. The osteoconductive only occurred in the presence of hydroxyapatite and bioactive glass (C15 Group) and little biodegradation was observed.

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confidence: 72%

Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

Santos

Facco

Ortiz³

et al. 2017

Acta Cir. Bras.

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“…Ceramic materials are commonly used in bone implantation. 13,14 Particular interest is focused on bioactive ceramics, including sintered hydroxyapatite (HAP) which bonds to the living bone through the bone-like apatite layer being formed on ceramic surfaces in the biomimetic process of the living body. 3 Such approach holds the promise for biodegradable and biocompatible polymer/ceramic composite materials able to mimic the bone healing process.…”

Section: Introductionmentioning

confidence: 99%

Bone Healing in the Presence of a Biodegradable PBS-DLA Copolyester and Its Composite Containing Hydroxyapatite

et al. 2019

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The healing process of the fractured bone in a presence of poly(butylene succinate-butylene dilinoleate) (PBS-DLA) copolymer containing nanosized hydroxyapatite (HAP) particles has been investigated. The PBS-DLA material containing PBS hard segments and DLA soft segments (50:50 wt %) was used to prepare a polymer/ceramic composite with 30 wt % HAP. A new PBS-DLA copolymer showed a high elasticity of 500% and 15 MPa tensile strength. Addition of HAP improved tensile strength up to 25 MPa while high elasticity has been preserved going down only to 300% of elongation at break. A polymer nanocomposite was fabricated into small elastic polymer rods 15 mm long and 1 × 2 mm in cross section and used for tibia bone fixation in rats. Mallory trichrome staining indicated that new biodegradable copolymers and its composite containing HAP have triggered the most advanced bone healing of all tested materials, thus indicating their high potential for bone tissue engineering and repair.

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Mesoporous silica SBA-16/hydroxyapatite-based composite for ciprofloxacin delivery to bacterial bone infection

Andrade

Faria

Gomes

et al. 2017

J Sol-Gel Sci Technol

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Hydroxyapatite, polycaprolactone and alendronate composites for bone regeneration in rabbits' olecranon: histological features

Abstract: Communication [Comunicação] Hydroxyapatite, polycaprolactone and alendronate composites for bone regeneration in rabbits' olecranon: histological features

Cited by 5 publications

References 11 publications

Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

Bone Healing in the Presence of a Biodegradable PBS-DLA Copolyester and Its Composite Containing Hydroxyapatite

Mesoporous silica SBA-16/hydroxyapatite-based composite for ciprofloxacin delivery to bacterial bone infection

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