Mesoporous silica SBA-16/hydroxyapatite-based composite for ciprofloxacin delivery to bacterial bone infection

Andrade, Gracielle Ferreira; Faria, Jerusa Araújo Quintão Arantes; Gomes, Dawidson Assis; Barros, André Luís Branco de; Fernandes, Renata Salgado; Coelho, Amanda Cristina Soares; Takahashi, Jacqueline A.; Silva-Cunha, Armando; Sousa, Edésia Martins Barros de

doi:10.1007/s10971-017-4557-y

Cited by 19 publications

(8 citation statements)

References 32 publications

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“…In this context, Andrade et al . (117) fabricated ciprofloxacin (CIP)-loaded SBA-16-type MSNs and SBA-16/hydroxyapatite (HA) composites for bone infection treatment. Both nanoplatforms were modified with 3-aminopropyltriethoxysilane (APTES), anchored with diethylenetriaminepentaacetic acid (DTPA) for chelating technetium-99m.…”

Section: Bacterial Infectionsmentioning

confidence: 99%

“…The association of multifunctional MSNs with antimicrobial drugs allows besides controlled drug release, efficient internalization in the bacterial environment ( 111 , 152 ). Drug-loaded mesoporous silica carriers were reported to access bone infections since fluids circulation in this region is very low which reduce drugs bioavailability via conventional administration ( 114 , 117 ). In addition, the MSNs specificity can be achieved by easily functionalization improving nanoplatforms action in target sites and controlled drugs release minimizing side effects.…”

Section: Msns For Infectious Diseases Treatmentmentioning

confidence: 99%

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Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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Infectious diseases are a major global concern being responsible for high morbidity and mortality mainly due to the development and enhancement of multidrug-resistant microorganisms exposing the fragility of medicines and vaccines commonly used to these treatments. Taking into account the scarcity of effective formulation to treat infectious diseases, nanotechnology offers a vast possibility of groundbreaking platforms to design new treatment through smart nanostructures for drug delivery purposes. Among the available nanosystems, mesoporous silica nanoparticles (MSNs) stand out due their multifunctionality, biocompatibility and tunable properties make them emerging and actual nanocarriers for specific and controlled drug release. Considering the high demand for diseases prevention and treatment, this review exploits the MSNs fabrication and their behavior in biological media besides highlighting the most of strategies to explore the wide MSNs functionality as engineered, smart and effective controlled drug release nanovehicles for infectious diseases treatment.

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Section: Bacterial Infectionsmentioning

confidence: 99%

Section: Msns For Infectious Diseases Treatmentmentioning

confidence: 99%

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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“…23,31 Initially, 3 g of ammonium fluoride (NH 4 F) was added to 450 mL of water at 80°C. 23,31 Initially, 3 g of ammonium fluoride (NH 4 F) was added to 450 mL of water at 80°C.…”

Section: Synthesis Of Silica/hydroxyapatitecopper Nanocomposite-(msmentioning

confidence: 99%

“…Silica nanocomposites with hydroxyapatite and copper were prepared based on a route adapted from literature. 23,31 Initially, 3 g of ammonium fluoride (NH 4 F) was added to 450 mL of water at 80°C. Then, 1.8 g of F127, a templating agent, 1.33 g of ammonium phosphate ((NH 4 ) 3 PO 4 ) and 195 mg of copper (II) nitrate were added to the initial solution.…”

Section: Synthesis Of Silica/hydroxyapatitecopper Nanocomposite-(msmentioning

confidence: 99%

Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Apostolos¹,

Andrade²,

Silva³

et al. 2019

Int J Applied Ceramic Tech

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In this study, we report the production of a mesoporous silica/hydroxyapatite‐based nanocomposite containing copper (Cu) functionalized with methacrylic acid (MAA), a pH‐sensitive polymer. The functionalization of the nanoparticles surface was performed using the microwave method in order to anchor the cross‐linking tetraethylene glycol dimethacrylate (TEGDMA), onto the nanoparticles surface followed by MAA polymerization. The materials were characterized by XRD, XRF spectroscopy, scanning and transmission electron microscopy, Fourier transform infrared spectroscopy, thermal analysis, zeta potential, and elemental analysis. Studies of the incorporation and release of the antitumor methotrexate drug were performed in order to evaluate the potential use of these drug carrier systems in cancer therapy. Moreover, the in vitro cytotoxicity of the samples in fibroblast and SAOS‐2 cells was investigated, and the activity of the adipose‐derived stem cell alkaline phosphatase on nanocomposites was studied by in vitro assays. The results indicate that the Cu‐containing nanocomposites can be easily produced and that these compositions have beneficial effects in stem cells, maintaining cell viability, and allowing alkaline phosphatase expression. In conclusion, data from this work show that the nanocomposites obtained have adequate characteristic to be used as drug delivery platform. Furthermore, the biomaterial is a promising structure for treatment of bone tumor.

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“…Finally, if we consider that the process of matrix modification is also sensitive to nature of metallic ions carried by precursors, one can imagine its vast complexity and wealth of various nanocomposites it may provide. To date, the evidence of the ample variability of systems based on matrices mentioned above is available 14,16–18 .…”

Section: Introductionmentioning

confidence: 99%

Size and distribution of the iron oxide nanoparticles in SBA-15 nanoporous silica via SANS study

Zeleňáková

Hrubovčák

Kapusta

et al. 2019

Sci Rep

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Structural characteristics of nanocomposite series consisting of iron oxide nanoparticles (NPs) embedded in the regular pores of amorphous silica matrix (SBA-15) were investigated by means of small angle neutron scattering (SANS). By virtue of unique neutron properties, insight into the inner structure and matter organization of this kind of systems was facilitated for the first time. Based on rigorous experimental support, fundamental model describing the neutron scattering intensity distribution was proposed by assuming general composite structural features. Model application to SANS data confirmed the presence of iron oxide NPs in the body of examined matrices, providing additional information on their shape, concentration and size distribution. Scattering superposition principle employed in the model conception allows for tailoring its fundamental characteristics, and renders it a potent and versatile tool for a wide range of applications.

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Mesoporous silica SBA-16/hydroxyapatite-based composite for ciprofloxacin delivery to bacterial bone infection

Cited by 19 publications

References 32 publications

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Size and distribution of the iron oxide nanoparticles in SBA-15 nanoporous silica via SANS study

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