Fluoroquinolones in industrial poultry production, bacterial resistance and food residues:a review

Gouvêa, Raquel; Santos, Felipe Faccini dos; Aquino, Mhc de; De, Anwesa

doi:10.1590/1516-635x17011-10

Cited by 75 publications

(49 citation statements)

References 21 publications

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“…We also observed a similar pattern in our previous study on antibiotic and virulence determinants in E. coli from cattle farms in the same locality, thus supporting this finding [16]. The use of quinolones in food-producing animals poses a great concern as they are medically important antibiotics with broadspectrum activity against several infections in humans, including foodborne infections [32]. Hence, their use in livestock should be discouraged despite the susceptibility found.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Antibiotic resistance profiles of Escherichia coli O26, O145, and O157:H7 isolated from swine in the Eastern Cape Province, South Africa

Iwu

Jaja

Iweriebor

et al. 2017

APJTD

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Section: Discussionsupporting

confidence: 89%

“…These bacteria could serve as reservoirs of resistance determinants that may spread through the food chain, reducing the efficacy of antimicrobials used in both human and veterinary medicine [31,32].…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance profiles of Escherichia coli O26, O145, and O157:H7 isolated from swine in the Eastern Cape Province, South Africa

Iwu

Jaja

Iweriebor

et al. 2017

APJTD

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“…Tetracyclines have a long history in the treatment of infectious diseases [3] while ciprofloxacin (major metabolite of enrofloxacin) is widely use in human and veterinary medicine [4]. As the use of these antibiotics increases, so do resistance to them.…”

Section: Introductionmentioning

confidence: 99%

High resistance to tetracycline and ciprofloxacin in bacteria isolated from poultry farms in Ibadan, Nigeria

Ayandiran

Falgenhauer

Schmiedel

et al. 2018

J Infect Dev Ctries

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Introduction: Resistance to ciprofloxacin and tetracycline is increasing in the food chain especially in E. coli strains and more worrisome will be occurrence of extended-spectrum beta-lactamase (ESBL) producers among ciprofloxacin-and tetracycline-resistant isolates. This study was undertaken to investigate the occurrence and mechanism of ciprofloxacin-, tetracycline-and ESBL-resistant bacteria in poultry in Ibadan, Nigeria. Methodology: Bacteria were isolated from poultry feces in two farms in Ibadan and identified by MALDI-TOF. Antibiotic susceptibility patterns of the isolates were determined by disc diffusion and Minimum Inhibitory Concentration (MIC) using Vitek-2 apparatus. Four tetracycline genes and six plasmids mediated quinolone resistance genes (PMQR) were investigated by PCR. Whole genome sequencing was done for strains that were ESBL producers. Results: Bacterial strains (≥ 10 5 cfu/mL) were counted on ciprofloxacin and tetracycline supplemented plates. 106 bacteria from 14 different species were identified with high resistance to quinolones, tetracycline and trimethoprim. 49% of the strains were E. coli with 90% resistance for nalidixic acid, moxifloxacin (94%), ciprofloxacin (88%) levofloxacin (78%) and tetracycline (77%). The genes tetA, tetB, qnrB, qnrS and qepA were detected with 37%, 4%, 35%, 4% and 2% prevalence in E. coli respectively. Three ESBL-producing E. coli of the sequence type ST-6359 were found and harboured blaCTX-M-15 located in the chromosome, at the same insertion site. All the ESBL producers harboured mutations in gyrA (S83L/D87N/D678E) and parC (S80I). Conclusion: The observed high quinolones and tetracycline resistance with ESBL producers in this study calls for caution in the use of these antibiotics in poultry feeds.

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“…In the late 1980s, enrofloxacin was the first approved fluoroquinolone to be used in veterinary medicine (Martineza et al, 2006). The most commonly used quinolones in different animal species and poultry overseas are ciprofloxacin, norfloxacin and enrofloxacin (Al-Mustafa and Al-Ghamdi, 2000; Gouvêa et al, 2015;Rodriguez-Martinez et al, 2006;Van Bambeke et al, 2005).…”

Section: Quinolonesmentioning

confidence: 99%

“…The variation in resistance reflects the difference in the antimicrobial usage policy of this drug in food-producing animals among the different countries (Kools et al, 2008). China and Brazil use fluoroquinolones for the treatment and prevention of infections in chickens (Gouvêa et al, 2015;Yassin et al, 2017).…”

Section: Quinolonesmentioning

confidence: 99%

Studies on avian pathogenic Escherichia coli in commercial broiler chicken in South East Queensland

Awawdeh¹,

Turni²,

Henning³

et al.

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Avian pathogenic Escherichia coli (APEC) is the causative agent of avian colibacillosis, a localised or systemic infection resulting in clinical diseases such as colisepticemia, chronic respiratory disease and swollen-head syndrome. Globally, avian colibacillosis is the leading cause of morbidity and mortality in poultry, and it has been associated with massive economic losses and welfare problems.This organism is of public health significance as APEC is communicable to humans. The diagnosis of avian colibacillosis relies on clinical signs, typical pathological lesions and culture of E. coli from affected tissue(s). Antimicrobial therapy is often used both for treatment and control. Previous overseas studies have characterised APEC and identified virulence genes (VGs) that can be used as molecular markers for the identification of APEC. Little is known about APEC in broiler chickens in Australia.The aim of this thesis was to gain a better understanding of the epidemiology of APEC in Australian broiler flocks and how factors including presence of VGs and phylogenetic group can improve the identification of this pathotype in Australia. Firstly, three faecal DNA extraction methods were evaluated. Faeces were collected from healthy chickens and chickens with colibacillosis from commercial broiler farms in South East Queensland (SEQ). The extracted DNA was screened by a pentaplex-PCR for five APEC-associated VGs (iroN, iutA, iss, hlyF and ompT). DNA extracted from E. coli isolates cultured from the cloaca and organs of the birds were screened using the same PCR.Repeated bead beating plus column elution was the preferred DNA extraction method, as it yielded good PCR quality and adequate quantity DNA. However, identifying APEC by direct detection of the five VGs from the faecal material was not feasible as all of these genes were also detected in all of the birds. However, the VGs were more commonly detected in E. coli isolates cultured from birds with colibacillosis.A cross-sectional study was performed to estimate APEC farm-level prevalence in healthy broiler chickens in SEQ and to identify potential risk factors associated with the carriage of APEC. At the farm-level, all of the 40 farms sampled were positive for APEC, that is at least one bird per farm carried APEC, while the within-farm prevalence was 63% (95% Confidence Interval: 55.8, 70.2).Higher APEC within-farm bird-level prevalence was significantly associated with the usage of well water as a source of drinking water, failure to disinfect the water line after each flock, farm visitors not showering before entering the shed, distances greater than 20 metres between the car park and the poultry shed and the presence of wild birds within 50 metres of the shed. Chlorinating the drinking water combined with automatic water filtration reduced within-farm bird-level APEC prevalence. Page | 3Therefore, based on the results concluded from the multivariable model, improving biosecurity and water treatments might reduce APEC prevalence, decrease the risk of co...

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Fluoroquinolones in industrial poultry production, bacterial resistance and food residues:a review

Cited by 75 publications

References 21 publications

Antibiotic resistance profiles of Escherichia coli O26, O145, and O157:H7 isolated from swine in the Eastern Cape Province, South Africa

Antibiotic resistance profiles of Escherichia coli O26, O145, and O157:H7 isolated from swine in the Eastern Cape Province, South Africa

High resistance to tetracycline and ciprofloxacin in bacteria isolated from poultry farms in Ibadan, Nigeria

Studies on avian pathogenic Escherichia coli in commercial broiler chicken in South East Queensland

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